Literature DB >> 8132361

Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1 beta by human mononuclear phagocytes.

S Houldsworth1, P W Andrew, T J Mitchell.   

Abstract

Human peripheral blood monocytes and a human monocyte cell line were exposed to the toxin pneumolysin. Pneumolysin-exposed cells produced significantly larger amounts of tumor necrosis factor alpha and interleukin-1 beta than cells not exposed to the toxin. The viability of cells was not affected by the concentrations of pneumolysin used in the experiments.

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Year:  1994        PMID： 8132361      PMCID： PMC186313          DOI： 10.1128/iai.62.4.1501-1503.1994

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  20 in total

1.  Protection against lethal pneumococcal septicemia in pigs is associated with decreased levels of interleukin-6 in blood.

Authors:  H W Ziegler-Heitbrock; B Passlick; E Käfferlein; P G Coulie; J R Izbicki
Journal:  Infect Immun       Date:  1992-04       Impact factor: 3.441

2.  Production of interleukin-1 but not tumor necrosis factor by human monocytes stimulated with pneumococcal cell surface components.

Authors:  I Riesenfeld-Orn; S Wolpe; J F Garcia-Bustos; M K Hoffmann; E Tuomanen
Journal:  Infect Immun       Date:  1989-07       Impact factor: 3.441

3.  Effect of Streptococcus pneumoniae on human respiratory epithelium in vitro.

Authors:  C Steinfort; R Wilson; T Mitchell; C Feldman; A Rutman; H Todd; D Sykes; J Walker; K Saunders; P W Andrew
Journal:  Infect Immun       Date:  1989-07       Impact factor: 3.441

4.  Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae.

Authors:  A M Berry; J Yother; D E Briles; D Hansman; J C Paton
Journal:  Infect Immun       Date:  1989-07       Impact factor: 3.441

5.  Pneumolysin, the thiol-activated toxin of Streptococcus pneumoniae, does not require a thiol group for in vitro activity.

Authors:  F K Saunders; T J Mitchell; J A Walker; P W Andrew; G J Boulnois
Journal:  Infect Immun       Date:  1989-08       Impact factor: 3.441

6.  Nonsteroidal anti-inflammatory agents in the therapy for experimental pneumococcal meningitis.

Authors:  E Tuomanen; B Hengstler; R Rich; M A Bray; O Zak; A Tomasz
Journal:  J Infect Dis       Date:  1987-05       Impact factor: 5.226

7.  Induction of synthesis of components of the hydrogen peroxide-generating oxidase during activation of the human monocytic cell line U937 by interferon-gamma.

Authors:  P W Andrew; A K Robertson; D B Lowrie; A R Cross; O T Jones
Journal:  Biochem J       Date:  1987-11-15       Impact factor: 3.857

8.  Correlation between interleukin-1 production and engraftment of transplanted bone marrow stem cells in patients with lethal immunodeficiencies.

Authors:  I Sahdev; R O'Reilly; M K Hoffman
Journal:  Blood       Date:  1989-05-01       Impact factor: 22.113

9.  Pneumolysin induces the salient histologic features of pneumococcal infection in the rat lung in vivo.

Authors:  C Feldman; N C Munro; P K Jeffery; T J Mitchell; P W Andrew; G J Boulnois; D Guerreiro; J A Rohde; H C Todd; P J Cole
Journal:  Am J Respir Cell Mol Biol       Date:  1991-11       Impact factor: 6.914

10.  The role of cytokines in the generation of inflammation and tissue damage in experimental gram-positive meningitis.

Authors:  K Saukkonen; S Sande; C Cioffe; S Wolpe; B Sherry; A Cerami; E Tuomanen
Journal:  J Exp Med       Date:  1990-02-01       Impact factor: 14.307
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  77 in total

1.  Pneumolysin potentiates production of prostaglandin E(2) and leukotriene B(4) by human neutrophils.

Authors:  R Cockeran; H C Steel; T J Mitchell; C Feldman; R Anderson
Journal:  Infect Immun       Date:  2001-05       Impact factor: 3.441

2.  An Arcanobacterium (Actinomyces) pyogenes mutant deficient in production of the pore-forming cytolysin pyolysin has reduced virulence.

Authors:  B H Jost; J G Songer; S J Billington
Journal:  Infect Immun       Date:  1999-04       Impact factor: 3.441

3.  Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitis.

Authors:  Johann S Braun; Jack E Sublett; Dorette Freyer; Tim J Mitchell; John L Cleveland; Elaine I Tuomanen; Joerg R Weber
Journal:  J Clin Invest       Date:  2002-01       Impact factor: 14.808

4.  Sensitivities of human monocytes and epithelial cells to pneumolysin are different.

Authors:  Robert A Hirst; Hasan Yesilkaya; Edwin Clitheroe; Andrew Rutman; Nichola Dufty; Timothy J Mitchell; Christopher O'Callaghan; Peter W Andrew
Journal:  Infect Immun       Date:  2002-02       Impact factor: 3.441

5.  Effect on polymorphonuclear cell function of a human-specific cytotoxin, intermedilysin, expressed by Streptococcus intermedius.

Authors:  M G Macey; R A Whiley; L Miller; H Nagamune
Journal:  Infect Immun       Date:  2001-10       Impact factor: 3.441

6.  Induction of gamma interferon and nitric oxide by truncated pneumolysin that lacks pore-forming activity.

Authors:  Hisashi Baba; Ikuo Kawamura; Chikara Kohda; Takamasa Nomura; Yutaka Ito; Terumi Kimoto; Isao Watanabe; Satoshi Ichiyama; Masao Mitsuyama
Journal:  Infect Immun       Date:  2002-01       Impact factor: 3.441

7.  Pneumolysin-induced complement depletion during experimental pneumococcal bacteremia.

Authors:  R B Alcantara; L C Preheim; M J Gentry-Nielsen
Journal:  Infect Immun       Date:  2001-06       Impact factor: 3.441

8.  Peritoneal culture alters Streptococcus pneumoniae protein profiles and virulence properties.

Authors:  C J Orihuela; R Janssen; C W Robb; D A Watson; D W Niesel
Journal:  Infect Immun       Date:  2000-10       Impact factor: 3.441

9.  Reduced release of pneumolysin by Streptococcus pneumoniae in vitro and in vivo after treatment with nonbacteriolytic antibiotics in comparison to ceftriaxone.

Authors:  Annette Spreer; Holger Kerstan; Tobias Böttcher; Joachim Gerber; Alexander Siemer; Gregor Zysk; Timothy J Mitchell; Helmut Eiffert; Roland Nau
Journal:  Antimicrob Agents Chemother       Date:  2003-08       Impact factor: 5.191

10.  Seeligeriolysin O, a cholesterol-dependent cytolysin of Listeria seeligeri, induces gamma interferon from spleen cells of mice.

Authors:  Yutaka Ito; Ikuo Kawamura; Chikara Kohda; Hisashi Baba; Takamasa Nomura; Terumi Kimoto; Isao Watanabe; Masao Mitsuyama
Journal:  Infect Immun       Date:  2003-01       Impact factor: 3.441
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