Literature DB >> 12878534

Reduced release of pneumolysin by Streptococcus pneumoniae in vitro and in vivo after treatment with nonbacteriolytic antibiotics in comparison to ceftriaxone.

Annette Spreer1, Holger Kerstan, Tobias Böttcher, Joachim Gerber, Alexander Siemer, Gregor Zysk, Timothy J Mitchell, Helmut Eiffert, Roland Nau.   

Abstract

Pneumolysin, a virulence factor of Streptococcus pneumoniae with cytotoxic and proinflammatory activities, occurs at concentrations from 0.85 to 180 ng/ml in cerebrospinal fluid (CSF) of meningitis patients. In pneumococcal cultures and in a rabbit meningitis model, the concentrations of pneumolysin in supernatant and CSF were lower after addition of nonbacteriolytic bactericidal antibiotics (rifampin and clindamycin) than after incubation with ceftriaxone.

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Year:  2003        PMID： 12878534      PMCID： PMC166091          DOI： 10.1128/AAC.47.8.2649-2654.2003

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  28 in total

1.  Rifampin reduces early mortality in experimental Streptococcus pneumoniae meningitis.

Authors:  R Nau; A Wellmer; A Soto; K Koch; O Schneider; H Schmidt; J Gerber; U Michel; W Brück
Journal:  J Infect Dis       Date:  1999-06       Impact factor: 5.226

2.  The effect of Streptococcus pneumoniae pneumolysin on human respiratory epithelium in vitro.

Authors:  C Feldman; T J Mitchell; P W Andrew; G J Boulnois; R C Read; H C Todd; P J Cole; R Wilson
Journal:  Microb Pathog       Date:  1990-10       Impact factor: 3.738

Review 3.  Biological properties of pneumolysin.

Authors:  T J Mitchell; P W Andrew
Journal:  Microb Drug Resist       Date:  1997       Impact factor: 3.431

4.  Clindamycin therapy of experimental meningitis caused by penicillin- and cephalosporin-resistant Streptococcus pneumoniae.

Authors:  M M París; S Shelton; M Trujillo; S M Hickey; G H McCracken
Journal:  Antimicrob Agents Chemother       Date:  1996-01       Impact factor: 5.191

5.  A role for pneumolysin but not neuraminidase in the hearing loss and cochlear damage induced by experimental pneumococcal meningitis in guinea pigs.

Authors:  A J Winter; S D Comis; M P Osborne; M J Tarlow; J Stephen; P W Andrew; J Hill; T J Mitchell
Journal:  Infect Immun       Date:  1997-11       Impact factor: 3.441

6.  Lower lipoteichoic and teichoic acid CSF concentrations during treatment of pneumococcal meningitis with non-bacteriolytic antibiotics than with ceftriaxone.

Authors:  K Stuertz; H Schmidt; F Trostdorf; H Eiffert; M Mäder; R Nau
Journal:  Scand J Infect Dis       Date:  1999

7.  Detection of pneumolysin in sputum.

Authors:  Janice Wheeler; Roger Freeman; Michael Steward; Kirstine Henderson; Maureen J S Lee; Nigel H Piggott; Gary J A Eltringham; Angela Galloway
Journal:  J Med Microbiol       Date:  1999-09       Impact factor: 2.472

8.  Immunization of mice with pneumolysin toxoid confers a significant degree of protection against at least nine serotypes of Streptococcus pneumoniae.

Authors:  J E Alexander; R A Lock; C C Peeters; J T Poolman; P W Andrew; T J Mitchell; D Hansman; J C Paton
Journal:  Infect Immun       Date:  1994-12       Impact factor: 3.441

9.  Bactericidal activity against cephalosporin-resistant Streptococcus pneumoniae in cerebrospinal fluid of children with acute bacterial meningitis.

Authors:  K P Klugman; I R Friedland; J S Bradley
Journal:  Antimicrob Agents Chemother       Date:  1995-09       Impact factor: 5.191

10.  Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1 beta by human mononuclear phagocytes.

Authors:  S Houldsworth; P W Andrew; T J Mitchell
Journal:  Infect Immun       Date:  1994-04       Impact factor: 3.441
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  41 in total

1.  Streptococcus pneumoniae-induced inhibition of rat ependymal cilia is attenuated by antipneumolysin antibody.

Authors:  Robert A Hirst; Bashir J Mohammed; Timothy J Mitchell; Peter W Andrew; Christopher O'Callaghan
Journal:  Infect Immun       Date:  2004-11       Impact factor: 3.441

2.  Doxycycline reduces mortality and injury to the brain and cochlea in experimental pneumococcal meningitis.

Authors:  Damian N Meli; Roney S Coimbra; Dominik G Erhart; Gerard Loquet; Caroline L Bellac; Martin G Täuber; Ulf Neumann; Stephen L Leib
Journal:  Infect Immun       Date:  2006-07       Impact factor: 3.441

3.  Acute Bacterial Meningitis: Challenges to Better Antibiotic Therapy.

Authors:  Colin Kietzman; Elaine Tuomanen
Journal:  ACS Infect Dis       Date:  2019-07-03       Impact factor: 5.084

Review 4.  Role of pore-forming toxins in bacterial infectious diseases.

Authors:  Ferdinand C O Los; Tara M Randis; Raffi V Aroian; Adam J Ratner
Journal:  Microbiol Mol Biol Rev       Date:  2013-06       Impact factor: 11.056

5.  Pneumolysin induces platelet destruction, not platelet activation, which can be prevented by immunoglobulin preparations in vitro.

Authors:  Kristin Jahn; Stefan Handtke; Raghavendra Palankar; Sabrina Weißmüller; Geraldine Nouailles; Thomas P Kohler; Jan Wesche; Manfred Rohde; Corina Heinz; Axel F Aschenbrenner; Martina Wolff; Jörg Schüttrumpf; Martin Witzenrath; Sven Hammerschmidt; Andreas Greinacher
Journal:  Blood Adv       Date:  2020-12-22

6.  Is in vitro antibiotic combination more effective than single-drug therapy against anthrax?

Authors:  Abed Athamna; Muhammad Athamna; Aburashed Nura; Eli Shlyakov; Darrin J Bast; David Farrell; Ethan Rubinstein
Journal:  Antimicrob Agents Chemother       Date:  2005-04       Impact factor: 5.191

7.  Streptococcus pneumoniae-induced caspase 6-dependent apoptosis in lung epithelium.

Authors:  Bernd Schmeck; Ralph Gross; Phillipe Dje N'Guessan; Andreas C Hocke; Sven Hammerschmidt; Tim J Mitchell; Simone Rosseau; Norbert Suttorp; Stefan Hippenstiel
Journal:  Infect Immun       Date:  2004-09       Impact factor: 3.441

8.  Differences in clinical manifestation of Streptococcus pneumoniae infection are not correlated with in vitro production and release of the virulence factors pneumolysin and lipoteichoic and teichoic acids.

Authors:  Annette Spreer; Astrid Lis; Joachim Gerber; Ralf René Reinert; Helmut Eiffert; Roland Nau
Journal:  J Clin Microbiol       Date:  2004-07       Impact factor: 5.948

9.  Pneumolysin activates neutrophil extracellular trap formation.

Authors:  J G Nel; A J Theron; C Durandt; G R Tintinger; R Pool; T J Mitchell; C Feldman; R Anderson
Journal:  Clin Exp Immunol       Date:  2016-03-02       Impact factor: 4.330

10.  Systemic expression of cytokine production in patients with severe pneumococcal pneumonia: effects of treatment with a beta-lactam versus a fluoroquinolone.

Authors:  Esther Calbo; Montserrat Alsina; Mónica Rodríguez-Carballeira; Josep Lite; Javier Garau
Journal:  Antimicrob Agents Chemother       Date:  2008-04-21       Impact factor: 5.191
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