Literature DB >> 8131066

Myo-inositol reduces serotonin (5-HT2) receptor induced homologous and heterologous desensitization.

S Rahman1, R S Neuman.   

Abstract

The effect of myo-inositol was examined on 5-HT2 receptor mediated facilitation of NMDA depolarization of rat neocortical neurons in vitro. Myo-inositol (1-10 mM) potentiated the 5-HT facilitation, the potentiation increasing linearly with log 5-HT concentration. Myo-inositol also eliminated 5-HT induced heterologous desensitization of muscarinic and alpha 1-adrenergic receptor mediated facilitation. Our findings suggest that 5-HT induced homologous and heterologous desensitization results in part from depleting phosphoinositide substrate.

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Year:  1993        PMID： 8131066     DOI： 10.1016/0006-8993(93)91557-9

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  8 in total

1.  Inositol treatment of autism.

Authors:  J Levine; A Aviram; A Holan; A Ring; Y Barak; R H Belmaker
Journal:  J Neural Transm (Vienna)       Date:  1997       Impact factor: 3.575

2.  Inositol has behavioral effects with adaptation after chronic administration.

Authors:  H Cohen; M Kotler; Z Kaplan; M A Matar; O Kofman; R H Belmaker
Journal:  J Neural Transm (Vienna)       Date:  1997       Impact factor: 3.575

3.  Relevance of orbitofrontal neurochemistry for the outcome of cognitive-behavioural therapy in patients with obsessive-compulsive disorder.

Authors:  Bartosz Zurowski; Andreas Kordon; Wolfgang Weber-Fahr; Ulrich Voderholzer; Anne Katrin Kuelz; Tobias Freyer; Karina Wahl; Christian Büchel; Fritz Hohagen
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2012-03-17       Impact factor: 5.270

4.  Action of 5-hydroxytryptamine in facilitating N-methyl-D-aspartate depolarization of cortical neurones mimicked by calcimycin, cyclopiazonic acid and thapsigargin.

Authors:  S Rahman; R S Neuman
Journal:  Br J Pharmacol       Date:  1996-11       Impact factor: 8.739

5.  CSF inositol does not predict antidepressant response to inositol. Short communication.

Authors:  J Levine; L Kurtzman; A Rapoport; J Zimmerman; Y Bersudsky; J Shapiro; R H Belmaker; G Agam
Journal:  J Neural Transm (Vienna)       Date:  1996       Impact factor: 3.575

6.  Epi-inositol and inositol depletion: two new treatment approaches in affective disorder.

Authors:  Y Bersudsky; H Einat; Z Stahl; R H Belmaker
Journal:  Curr Psychiatry Rep       Date:  1999-12       Impact factor: 5.285

7.  Characterization of metabotropic glutamate receptor-mediated facilitation of N-methyl-D-aspartate depolarization of neocortical neurones.

Authors:  S Rahman; R S Neuman
Journal:  Br J Pharmacol       Date:  1996-02       Impact factor: 8.739

8.  Effects of myo-inositol versus fluoxetine and imipramine pretreatments on serotonin 5HT2A and muscarinic acetylcholine receptors in human neuroblastoma cells.

Authors:  Christiaan B Brink; Susanna L Viljoen; Susanna E de Kock; Dan J Stein; Brian H Harvey
Journal:  Metab Brain Dis       Date:  2004-06       Impact factor: 3.584
  8 in total

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