Literature DB >> 8123499

Mucin-associated sialosyl-Tn antigen expression in gastric cancer correlates with an adverse outcome.

J L Werther1, S Rivera-MacMurray, H Bruckner, M Tatematsu, S H Itzkowitz.   

Abstract

The expression of sialosyl-Tn (STn) antigen was evaluated by immunohistochemistry in primary gastric cancers. Twenty-one of 31 (68%) gastric cancers expressed STn, regardless of tumour location, stage or histological type. Eighty-one per cent of patients with STn-positive tumours died of their disease or had recurrent cancer, compared with 20% of patients with STn-negative tumours (P < 0.002). STn may be a useful prognostic marker in patients with gastric cancer.

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Year:  1994        PMID: 8123499      PMCID: PMC1968851          DOI: 10.1038/bjc.1994.114

Source DB:  PubMed          Journal:  Br J Cancer        ISSN: 0007-0920            Impact factor:   7.640


  19 in total

1.  Mosaicism in the expression of tumor-associated carbohydrate antigens in human colonic and gastric cancers.

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Journal:  Cancer Res       Date:  1989-07-01       Impact factor: 12.701

2.  Comparison of CA 72-4 with CA 19-9 and carcinoembryonic antigen in the serodiagnostics of gastrointestinal malignancies.

Authors:  G Heptner; S Domschke; W Domschke
Journal:  Scand J Gastroenterol       Date:  1989-08       Impact factor: 2.423

3.  Expression of Tn, sialosyl-Tn, and T antigens in human colon cancer.

Authors:  S H Itzkowitz; M Yuan; C K Montgomery; T Kjeldsen; H K Takahashi; W L Bigbee; Y S Kim
Journal:  Cancer Res       Date:  1989-01-01       Impact factor: 12.701

4.  TAG-72 serum determination in early and advanced gastric cancer.

Authors:  F Farinati; M Plebani; D Faggian; F Di Mario; M C Fanton; F Valiante; A Burlina; R Naccarato
Journal:  Int J Cancer       Date:  1989-08-15       Impact factor: 7.396

5.  Sialosyl-Tn. A novel mucin antigen associated with prognosis in colorectal cancer patients.

Authors:  S H Itzkowitz; E J Bloom; W A Kokal; G Modin; S Hakomori; Y S Kim
Journal:  Cancer       Date:  1990-11-01       Impact factor: 6.860

Review 6.  Aberrant glycosylation in tumors and tumor-associated carbohydrate antigens.

Authors:  S Hakomori
Journal:  Adv Cancer Res       Date:  1989       Impact factor: 6.242

7.  Simple mucin-type carbohydrate antigens (Tn, sialosyl-Tn and T) in gastric mucosa, carcinomas and metastases.

Authors:  L David; J M Nesland; H Clausen; F Carneiro; M Sobrinho-Simões
Journal:  APMIS Suppl       Date:  1992

8.  Distribution of oncofetal antigen tumor-associated glycoprotein-72 defined by monoclonal antibody B72.3.

Authors:  A Thor; N Ohuchi; C A Szpak; W W Johnston; J Schlom
Journal:  Cancer Res       Date:  1986-06       Impact factor: 12.701

9.  Preparation and characterization of monoclonal antibodies directed to the tumor-associated O-linked sialosyl-2----6 alpha-N-acetylgalactosaminyl (sialosyl-Tn) epitope.

Authors:  T Kjeldsen; H Clausen; S Hirohashi; T Ogawa; H Iijima; S Hakomori
Journal:  Cancer Res       Date:  1988-04-15       Impact factor: 12.701

10.  Tumor-associated glycoprotein (TAG-72) expression in ulcerative colitis.

Authors:  A Thor; S H Itzkowitz; J Schlom; Y S Kim; S Hanauer
Journal:  Int J Cancer       Date:  1989-05-15       Impact factor: 7.396

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  19 in total

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3.  Protein glycosylation in cancer biology: an overview.

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Review 4.  Protein glycosylation in cancer.

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5.  A novel and efficient method for synthetic carbohydrate conjugate vaccine preparation: synthesis of sialyl Tn-KLH conjugate using a 4-(4-N-maleimidomethyl) cyclohexane-1-carboxyl hydrazide (MMCCH) linker arm.

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Journal:  Glycoconj J       Date:  1998-03       Impact factor: 2.916

6.  RNAi-mediated gene silencing of ST6GalNAc I suppresses the metastatic potential in gastric cancer cells.

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Journal:  Gastric Cancer       Date:  2014-12-23       Impact factor: 7.370

7.  Different modes of sialyl-Tn expression during malignant transformation of human colonic mucosa.

Authors:  S Ogata; R Koganty; M Reddish; B M Longenecker; A Chen; C Perez; S H Itzkowitz
Journal:  Glycoconj J       Date:  1998-01       Impact factor: 2.916

8.  Preliminary joint neutron time-of-flight and X-ray crystallographic study of human ABO(H) blood group A glycosyltransferase.

Authors:  B Schuman; S Z Fisher; A Kovalevsky; S N Borisova; M M Palcic; L Coates; P Langan; S V Evans
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2011-01-22

9.  Sialyl-Tn antigen as a useful predictor of poor prognosis in patients with advanced stomach cancer.

Authors:  S Terashima; Y Takano; T Ohori; T Kanno; T Kimura; R Motoki; T Kawaguchi
Journal:  Surg Today       Date:  1998       Impact factor: 2.549

10.  A rat model to study the role of STn antigen in colon cancer.

Authors:  S Ogata; I Ho; J Maklansky; A Chen; J L Werther; M Reddish; B M Longenecker; E Sigurdson; S Iishi; J Y Zhang; S H Itzkowitz
Journal:  Glycoconj J       Date:  2001 Nov-Dec       Impact factor: 2.916

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