Literature DB >> 9697259

Sialyl-Tn antigen as a useful predictor of poor prognosis in patients with advanced stomach cancer.

S Terashima1, Y Takano, T Ohori, T Kanno, T Kimura, R Motoki, T Kawaguchi.   

Abstract

Sialyl-Tn antigen (STn) expression was studied immunohistochemically in 211 primary advanced gastric carcinomas. The overall rate of positive STn staining was 17% (35/211), and positive STn staining was found not to be correlated with tumor size, depth of invasion, lymph node metastasis, liver metastasis, or peritoneal metastasis. However, patients with tumors that were immunoreactive for STn demonstrated significantly lower survival (P < 0.05). Multivariate analysis revealed that STn staining was an independent prognostic factor. From these findings we conclude that careful followup and intense postoperative therapy are required for patients with advanced gastric cancer who have positive immunoreactivity for STn.

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Year:  1998        PMID： 9697259     DOI： 10.1007/BF02484612

Source DB:  PubMed          Journal:  Surg Today        ISSN： 0941-1291            Impact factor:   2.549


  13 in total

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Journal:  J Clin Oncol       Date:  1992-01       Impact factor: 44.544

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Journal:  Br J Surg       Date:  1995-07       Impact factor: 6.939

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Journal:  Adv Cancer Res       Date:  1989       Impact factor: 6.242

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Journal:  Cancer       Date:  1993-09-15       Impact factor: 6.860

5.  Sialyl Tn antigen is an independent predictor of outcome in patients with gastric cancer.

Authors:  M Victorzon; S Nordling; O Nilsson; P J Roberts; C Haglund
Journal:  Int J Cancer       Date:  1996-01-26       Impact factor: 7.396

6.  Expression of sialyl-Tn antigen is correlated with survival time of patients with gastric carcinomas.

Authors:  X C Ma; N Terata; M Kodama; S Jancic; Y Hosokawa; T Hattori
Journal:  Eur J Cancer       Date:  1993       Impact factor: 9.162

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Authors:  S Yonezawa; T Tachikawa; S Shin; E Sato
Journal:  Am J Clin Pathol       Date:  1992-08       Impact factor: 2.493

8.  Mucin-associated sialosyl-Tn antigen expression in gastric cancer correlates with an adverse outcome.

Authors:  J L Werther; S Rivera-MacMurray; H Bruckner; M Tatematsu; S H Itzkowitz
Journal:  Br J Cancer       Date:  1994-03       Impact factor: 7.640

9.  Correlation between sialyl Tn antigen and lymphatic metastasis in patients with Borrmann type IV gastric carcinoma.

Authors:  Y Kakeji; Y Maehara; M Morita; A Matsukuma; M Furusawa; I Takahashi; T Kusumoto; S Ohno; K Sugimachi
Journal:  Br J Cancer       Date:  1995-01       Impact factor: 7.640

10.  Expression of sialyl-Tn in gastric cancer: correlation with known prognostic factors.

Authors:  D W Miles; J Linehan; P Smith; I Filipe
Journal:  Br J Cancer       Date:  1995-05       Impact factor: 7.640
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  7 in total

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Journal:  Mol Oncol       Date:  2013-03-21       Impact factor: 6.603

Review 3.  Challenges in Antibody Development against Tn and Sialyl-Tn Antigens.

Authors:  Liliana R Loureiro; Mylène A Carrascal; Ana Barbas; José S Ramalho; Carlos Novo; Philippe Delannoy; Paula A Videira
Journal:  Biomolecules       Date:  2015-08-11

4.  Development of antimetastatic drugs by targeting tumor sialic acids.

Authors:  Da-Yong Lu; Ting-Ren Lu; Hong-Ying Wu
Journal:  Sci Pharm       Date:  2012-06-18

5.  Sialyl-tn in cancer: (how) did we miss the target?

Authors:  Sylvain Julien; Paula A Videira; Philippe Delannoy
Journal:  Biomolecules       Date:  2012-10-11

Review 6.  Esophageal, gastric and colorectal cancers: Looking beyond classical serological biomarkers towards glycoproteomics-assisted precision oncology.

Authors:  Elisabete Fernandes; Janine Sores; Sofia Cotton; Andreia Peixoto; Dylan Ferreira; Rui Freitas; Celso A Reis; Lúcio Lara Santos; José Alexandre Ferreira
Journal:  Theranostics       Date:  2020-03-31       Impact factor: 11.556

7.  ST6GalNAc-I promotes lung cancer metastasis by altering MUC5AC sialylation.

Authors:  Imayavaramban Lakshmanan; Sanjib Chaudhary; Raghupathy Vengoji; Parthasarathy Seshacharyulu; Satyanarayana Rachagani; Joseph Carmicheal; Rahat Jahan; Pranita Atri; Ramakanth Chirravuri-Venkata; Rohitesh Gupta; Saravanakumar Marimuthu; Naveenkumar Perumal; Sanchita Rauth; Sukhwinder Kaur; Kavita Mallya; Lynette M Smith; Subodh M Lele; Moorthy P Ponnusamy; Mohd W Nasser; Ravi Salgia; Surinder K Batra; Apar Kishor Ganti
Journal:  Mol Oncol       Date:  2021-05-01       Impact factor: 6.603
  7 in total

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