OBJECTIVE: To determine the prevalence of diabetes mellitus and impaired glucose tolerance (IGT) and to test for bimodality in the plasma glucose distribution in South African Indians. RESEARCH DESIGN AND METHODS: Subjects were selected by systematic cluster sampling in various areas of Durban. They underwent a modified glucose tolerance test whereby fasting and 2-h postglucose (75 g) plasma glucose levels were measured. The program MIX was used to test for bimodality in the plasma glucose distribution. RESULTS: We tested 2,479 subjects (1,441 women and 1,038 men). Based on the revised World Health Organization criteria, the crude prevalence of diabetes mellitus was 9.8%, and the crude prevalence of IGT was 5.8%; the age- and sex-adjusted prevalence was 13.0 and 6.9%, respectively. IGT was significantly more common in men (7.6%) than in women (4.4%). Obesity was a feature of both diabetes mellitus and IGT, particularly in women. Both fasting and 2-h plasma glucose values did not conform to a single normal distribution pattern in any age-group, whereas unequivocal evidence of bimodality was seen in the 55- to 74-year age-group of both sexes for fasting and 2-h glucose and also in the 2-h levels of men in the 25- to 34-year age-group. CONCLUSIONS: This study has highlighted a high prevalence of non-insulin-dependent diabetes mellitus in South African Indians and bimodality in the plasma glucose distribution.
OBJECTIVE: To determine the prevalence of diabetes mellitus and impaired glucose tolerance (IGT) and to test for bimodality in the plasma glucose distribution in South African Indians. RESEARCH DESIGN AND METHODS: Subjects were selected by systematic cluster sampling in various areas of Durban. They underwent a modified glucose tolerance test whereby fasting and 2-h postglucose (75 g) plasma glucose levels were measured. The program MIX was used to test for bimodality in the plasma glucose distribution. RESULTS: We tested 2,479 subjects (1,441 women and 1,038 men). Based on the revised World Health Organization criteria, the crude prevalence of diabetes mellitus was 9.8%, and the crude prevalence of IGT was 5.8%; the age- and sex-adjusted prevalence was 13.0 and 6.9%, respectively. IGT was significantly more common in men (7.6%) than in women (4.4%). Obesity was a feature of both diabetes mellitus and IGT, particularly in women. Both fasting and 2-h plasma glucose values did not conform to a single normal distribution pattern in any age-group, whereas unequivocal evidence of bimodality was seen in the 55- to 74-year age-group of both sexes for fasting and 2-h glucose and also in the 2-h levels of men in the 25- to 34-year age-group. CONCLUSIONS: This study has highlighted a high prevalence of non-insulin-dependent diabetes mellitus in South African Indians and bimodality in the plasma glucose distribution.
Authors: Viveka Kalidasan; Xin Yang; Ze Xiong; Renee R Li; Haicheng Yao; Hareesh Godaba; Sybil Obuobi; Priti Singh; Xin Guan; Xi Tian; Selman A Kurt; Zhipeng Li; Devika Mukherjee; Ravisankar Rajarethinam; Choon Seng Chong; Jiong-Wei Wang; Pui Lai Rachel Ee; Weiqiang Loke; Benjamin C K Tee; Jianyong Ouyang; Christopher J Charles; John S Ho Journal: Nat Biomed Eng Date: 2021-10-15 Impact factor: 25.671
Authors: M I McCarthy; G A Hitman; D C Shields; N E Morton; C Snehalatha; V Mohan; A Ramachandran; M Viswanathan Journal: Diabetologia Date: 1994-12 Impact factor: 10.122
Authors: T Nakagami; Q Qiao; B Carstensen; C Nhr-Hansen; G Hu; J Tuomilehto; B Balkau; K Borch-Johnsen Journal: Diabetologia Date: 2003-06-25 Impact factor: 10.122
Authors: Timo E Saaristo; Noël C Barengo; Eeva Korpi-Hyövälti; Heikki Oksa; Hannu Puolijoki; Juha T Saltevo; Mauno Vanhala; Jouko Sundvall; Liisa Saarikoski; Markku Peltonen; Jaakko Tuomilehto Journal: BMC Public Health Date: 2008-12-29 Impact factor: 3.295