Literature DB >> 8108730

Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster.

W C Orr1, R S Sohal.   

Abstract

The hypothesis that oxygen free radicals are causally involved in the aging process was tested by a study of the effects of simultaneous overexpression of copper-zinc superoxide dismutase and catalase. As compared to diploid controls, transgenic flies carrying three copies of each of these genes exhibited as much as a one-third extension of life-span, a longer mortality rate doubling time, a lower amount of protein oxidative damage, and a delayed loss in physical performance. Results provide direct support for the free radical hypothesis of aging.

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Year:  1994        PMID： 8108730     DOI： 10.1126/science.8108730

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  274 in total

1.  Influence of sex, smoking and age on human hprt mutation frequencies and spectra.

Authors:  J Curry; L Karnaoukhova; G C Guenette; B W Glickman
Journal:  Genetics       Date:  1999-07       Impact factor: 4.562

2.  Genome-wide study of aging and oxidative stress response in Drosophila melanogaster.

Authors:  S Zou; S Meadows; L Sharp; L Y Jan; Y N Jan
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-05       Impact factor: 11.205

Review 3.  Aging-related changes in skeletal muscle. Mechanisms and interventions.

Authors:  L Larsson; B Ramamurthy
Journal:  Drugs Aging       Date:  2000-10       Impact factor: 3.923

4.  Quantitative trait loci for life span in Drosophila melanogaster: interactions with genetic background and larval density.

Authors:  J Leips; T F Mackay
Journal:  Genetics       Date:  2000-08       Impact factor: 4.562

5.  Life extension in Drosophila by feeding a drug.

Authors:  Hyung-Lyun Kang; Seymour Benzer; Kyung-Tai Min
Journal:  Proc Natl Acad Sci U S A       Date:  2002-01-15       Impact factor: 11.205

6.  Maternal and grandmaternal age influence offspring fitness in Drosophila.

Authors:  M J Hercus; A A Hoffmann
Journal:  Proc Biol Sci       Date:  2000-10-22       Impact factor: 5.349

7.  Bacterial senescence: protein oxidation in non-proliferating cells is dictated by the accuracy of the ribosomes.

Authors:  M Ballesteros; A Fredriksson; J Henriksson; T Nyström
Journal:  EMBO J       Date:  2001-09-17       Impact factor: 11.598

8.  Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals.

Authors:  J Moskovitz; S Bar-Noy; W M Williams; J Requena; B S Berlett; E R Stadtman
Journal:  Proc Natl Acad Sci U S A       Date:  2001-10-23       Impact factor: 11.205

9.  Cloning, Sequence, and Expression Analysis of a New MnSOD-Encoding Gene from the Root-Knot Nematode Meloidogyne incognita.

Authors:  Laura C Rosso
Journal:  J Nematol       Date:  2009-03       Impact factor: 1.402

10.  Superoxide dismutase 1 knockdown induces oxidative stress and DNA methylation loss in the prostate.

Authors:  Sachin S Bhusari; Joseph R Dobosy; Vivian Fu; Nima Almassi; Terry Oberley; David F Jarrard
Journal:  Epigenetics       Date:  2010-07-01       Impact factor: 4.528
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