Literature DB >> 11792861

Life extension in Drosophila by feeding a drug.

Hyung-Lyun Kang1, Seymour Benzer, Kyung-Tai Min.   

Abstract

We report that feeding Drosophila throughout adulthood with 4-phenylbutyrate (PBA) can significantly increase lifespan, without diminution of locomotor vigor, resistance to stress, or reproductive ability. Treatment for a limited period, either early or late in adult life, is also effective. Flies fed PBA show a global increase in histone acetylation as well as a dramatically altered pattern of gene expression, including induction or repression of numerous genes. The delay in aging may result from the altered physiological state.

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Year:  2002        PMID： 11792861      PMCID： PMC117392          DOI： 10.1073/pnas.022631999

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  38 in total

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Journal:  Science       Date:  1994-02-25       Impact factor: 47.728

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Journal:  J Biol Chem       Date:  1974-06-25       Impact factor: 5.157

4.  Inhibitors of histone deacetylase relieve ETO-mediated repression and induce differentiation of AML1-ETO leukemia cells.

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Journal:  Cancer Res       Date:  1999-06-15       Impact factor: 12.701

5.  A pilot clinical trial of oral sodium 4-phenylbutyrate (Buphenyl) in deltaF508-homozygous cystic fibrosis patients: partial restoration of nasal epithelial CFTR function.

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Journal:  Am J Respir Crit Care Med       Date:  1998-02       Impact factor: 21.405

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Journal:  Mol Biol Cell       Date:  1999-10       Impact factor: 4.138

7.  Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila.

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8.  Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons.

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Journal:  Nat Med       Date:  1998-11       Impact factor: 53.440

10.  Oral sodium phenylbutyrate therapy in homozygous beta thalassemia: a clinical trial.

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Journal:  Blood       Date:  1995-01-01       Impact factor: 22.113
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  105 in total

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Review 3.  Epigenetic control of aging.

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Journal:  Antioxid Redox Signal       Date:  2010-11-22       Impact factor: 8.401

Review 4.  dSir2 and longevity in Drosophila.

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Journal:  Exp Gerontol       Date:  2010-08-20       Impact factor: 4.032

5.  Healthspan Pharmacology.

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Journal:  Genetics       Date:  2004-12       Impact factor: 4.562

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Journal:  Hum Mol Genet       Date:  2019-07-15       Impact factor: 6.150

9.  Enigma, a mitochondrial protein affecting lifespan and oxidative stress response in Drosophila.

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10.  Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor.

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Journal:  Science       Date:  2012-12-06       Impact factor: 47.728
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