Literature DB >> 8105651

Heterogeneity and stability characteristics of Candid 1 attenuated strain of Junin virus.

M Contigiani1, S Medeot, G Diaz.   

Abstract

Fourteen clones of Candid 1 strain of Junin virus were studied in terms of their attenuation and stability for 9 days-old mice. The cluster analysis of the efficiency of lethal infection, namely the virulence (lethality) indicates (PFU/LD50) of the clones showed that the strain population is heterogeneous. It is constituted by subpopulations with lower and higher virulence as compared to the parent strain. Moreover, one or two passages through mice and Calomys musculinus, the main Junin virus reservoir of this strain produced changes of its virulence meanwhile the in vitro passages did not affect its attenuation level.

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Year:  1993        PMID： 8105651

Source DB:  PubMed          Journal:  Acta Virol        ISSN： 0001-723X            Impact factor:   1.162


  11 in total

1.  The major determinant of attenuation in mice of the Candid1 vaccine for Argentine hemorrhagic fever is located in the G2 glycoprotein transmembrane domain.

Authors:  César G Albariño; Brian H Bird; Ayan K Chakrabarti; Kimberly A Dodd; Mike Flint; Eric Bergeron; David M White; Stuart T Nichol
Journal:  J Virol       Date:  2011-07-27       Impact factor: 5.103

2.  Arenavirus Genome Rearrangement for the Development of Live Attenuated Vaccines.

Authors:  Benson Yee Hin Cheng; Emilio Ortiz-Riaño; Juan Carlos de la Torre; Luis Martínez-Sobrido
Journal:  J Virol       Date:  2015-05-13       Impact factor: 5.103

3.  Development of live-attenuated arenavirus vaccines based on codon deoptimization.

Authors:  Benson Yee Hin Cheng; Emilio Ortiz-Riaño; Aitor Nogales; Juan Carlos de la Torre; Luis Martínez-Sobrido
Journal:  J Virol       Date:  2015-01-14       Impact factor: 5.103

4.  Reverse genetics generation of chimeric infectious Junin/Lassa virus is dependent on interaction of homologous glycoprotein stable signal peptide and G2 cytoplasmic domains.

Authors:  César G Albariño; Brian H Bird; Ayan K Chakrabarti; Kimberly A Dodd; David M White; Eric Bergeron; Punya Shrivastava-Ranjan; Stuart T Nichol
Journal:  J Virol       Date:  2010-10-27       Impact factor: 5.103

5.  A substitution in the transmembrane region of the glycoprotein leads to an unstable attenuation of Machupo virus.

Authors:  Michael Patterson; Takaaki Koma; Alexey Seregin; Cheng Huang; Milagros Miller; Jennifer Smith; Nadezhda Yun; Jeanon Smith; Slobodan Paessler
Journal:  J Virol       Date:  2014-07-16       Impact factor: 5.103

6.  General Molecular Strategy for Development of Arenavirus Live-Attenuated Vaccines.

Authors:  Masaharu Iwasaki; Nhi Ngo; Beatrice Cubitt; John R Teijaro; Juan C de la Torre
Journal:  J Virol       Date:  2015-09-23       Impact factor: 5.103

7.  Efficient reverse genetics generation of infectious junin viruses differing in glycoprotein processing.

Authors:  César G Albariño; Eric Bergeron; Bobbie Rae Erickson; Marina L Khristova; Pierre E Rollin; Stuart T Nichol
Journal:  J Virol       Date:  2009-03-25       Impact factor: 5.103

8.  Epistastic Interactions within the Junín Virus Envelope Glycoprotein Complex Provide an Evolutionary Barrier to Reversion in the Live-Attenuated Candid#1 Vaccine.

Authors:  Joanne York; Jack H Nunberg
Journal:  J Virol       Date:  2017-12-14       Impact factor: 5.103

9.  Development of Reverse Genetics for the Prototype New World Mammarenavirus Tacaribe Virus.

Authors:  Chengjin Ye; Juan Carlos de la Torre; Luis Martínez-Sobrido
Journal:  J Virol       Date:  2020-09-15       Impact factor: 5.103

10.  Envelope exchange for the generation of live-attenuated arenavirus vaccines.

Authors:  Andreas Bergthaler; Nicolas U Gerber; Doron Merkler; Edit Horvath; Juan Carlos de la Torre; Daniel D Pinschewer
Journal:  PLoS Pathog       Date:  2006-06-02       Impact factor: 6.823
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