Literature DB >> 25031335

A substitution in the transmembrane region of the glycoprotein leads to an unstable attenuation of Machupo virus.

Michael Patterson1, Takaaki Koma1, Alexey Seregin1, Cheng Huang1, Milagros Miller1, Jennifer Smith1, Nadezhda Yun1, Jeanon Smith1, Slobodan Paessler2.   

Abstract

Machupo virus (MACV) is the etiologic agent of Bolivian hemorrhagic fever (BHF). Utilizing a reverse-genetics system recently developed, we report the rescue of a rationally modified recombinant MACV containing a single mutation in the transmembrane region of the glycoprotein. Following challenge of susceptible mice, we identified a significant reduction in virulence in the novel virus. We also identified an instability leading to reversion of the single mutation to a wild-type genotype.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 25031335      PMCID： PMC4178861          DOI： 10.1128/JVI.01007-14

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  37 in total

1.  VIRUS ISOLATIONS FROM HUMAN CASES OF HEMORRHAGIC FEVER IN BOLIVIA.

Authors:  K M JOHNSON; N H WIEBENGA; R B MACKENZIE; M L KUNS; N M TAURASO; A SHELOKOV; P A WEBB; G JUSTINES; H K BEYE
Journal:  Proc Soc Exp Biol Med       Date:  1965-01

2.  [The isolation and characteristics of reassortants between the Lassa and Mopeia arenaviruses].

Authors:  I S Lukashevich; A D Vasiuchkov; T A Stel'makh; E P Scheslenok; A G Shabanov
Journal:  Vopr Virusol       Date:  1991 Mar-Apr

3.  Protective efficacy of a live attenuated vaccine against Argentine hemorrhagic fever. AHF Study Group.

Authors:  J I Maiztegui; K T McKee; J G Barrera Oro; L H Harrison; P H Gibbs; M R Feuillade; D A Enria; A M Briggiler; S C Levis; A M Ambrosio; N A Halsey; C J Peters
Journal:  J Infect Dis       Date:  1998-02       Impact factor: 5.226

4.  Generation of reassortants between African arenaviruses.

Authors:  I S Lukashevich
Journal:  Virology       Date:  1992-06       Impact factor: 3.616

5.  Nucleotide sequence of the Lassa virus (Josiah strain) S genome RNA and amino acid sequence comparison of the N and GPC proteins to other arenaviruses.

Authors:  D D Auperin; J B McCormick
Journal:  Virology       Date:  1989-02       Impact factor: 3.616

6.  Treatment of Bolivian hemorrhagic fever with intravenous ribavirin.

Authors:  P E Kilgore; T G Ksiazek; P E Rollin; J N Mills; M R Villagra; M J Montenegro; M A Costales; L C Paredes; C J Peters
Journal:  Clin Infect Dis       Date:  1997-04       Impact factor: 9.079

7.  Sequence heterogeneity in the termini of lymphocytic choriomeningitis virus genomic and antigenomic RNAs.

Authors:  B J Meyer; P J Southern
Journal:  J Virol       Date:  1994-11       Impact factor: 5.103

8.  Heterogeneity and stability characteristics of Candid 1 attenuated strain of Junin virus.

Authors:  M Contigiani; S Medeot; G Diaz
Journal:  Acta Virol       Date:  1993-02       Impact factor: 1.162

9.  Nucleotide sequence conservation at the 3' termini of the virion RNA species of New World and Old World arenaviruses.

Authors:  D D Auperin; R W Compans; D H Bishop
Journal:  Virology       Date:  1982-08       Impact factor: 3.616

10.  Isolation and characterization of Whitewater Arroyo virus, a novel North American arenavirus.

Authors:  C F Fulhorst; M D Bowen; T G Ksiazek; P E Rollin; S T Nichol; M Y Kosoy; C J Peters
Journal:  Virology       Date:  1996-10-01       Impact factor: 3.616
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  10 in total

1.  Highly Pathogenic New World and Old World Human Arenaviruses Induce Distinct Interferon Responses in Human Cells.

Authors:  Cheng Huang; Olga A Kolokoltsova; Nadezhda E Yun; Alexey V Seregin; Shannon Ronca; Takaaki Koma; Slobodan Paessler
Journal:  J Virol       Date:  2015-04-29       Impact factor: 5.103

2.  Machupo Virus with Mutations in the Transmembrane Domain and Glycosylation Sites of the Glycoprotein Is Attenuated and Immunogenic in Animal Models of Bolivian Hemorrhagic Fever.

Authors:  Emily K Mantlo; Junki Maruyama; John T Manning; Timothy G Wanninger; Cheng Huang; Jeanon N Smith; Michael Patterson; Slobodan Paessler; Takaaki Koma
Journal:  J Virol       Date:  2022-03-28       Impact factor: 6.549

3.  Bivalent Junin & Machupo experimental vaccine based on alphavirus RNA replicon vector.

Authors:  Dylan M Johnson; Jenny D Jokinen; Min Wang; Tia Pfeffer; Irina Tretyakova; Ricardo Carrion; Anthony Griffiths; Peter Pushko; Igor S Lukashevich
Journal:  Vaccine       Date:  2020-02-25       Impact factor: 3.641

4.  Machupo Virus Expressing GPC of the Candid#1 Vaccine Strain of Junin Virus Is Highly Attenuated and Immunogenic.

Authors:  Takaaki Koma; Michael Patterson; Cheng Huang; Alexey V Seregin; Payal D Maharaj; Milagros Miller; Jeanon N Smith; Aida G Walker; Steven Hallam; Slobodan Paessler
Journal:  J Virol       Date:  2015-11-18       Impact factor: 5.103

5.  The Ectodomain of Glycoprotein from the Candid#1 Vaccine Strain of Junin Virus Rendered Machupo Virus Partially Attenuated in Mice Lacking IFN-αβ/γ Receptor.

Authors:  Takaaki Koma; Cheng Huang; Judith F Aronson; Aida G Walker; Milagros Miller; Jeanon N Smith; Michael Patterson; Slobodan Paessler
Journal:  PLoS Negl Trop Dis       Date:  2016-08-31

6.  An attenuated Machupo virus with a disrupted L-segment intergenic region protects guinea pigs against lethal Guanarito virus infection.

Authors:  Joseph W Golden; Brett Beitzel; Jason T Ladner; Eric M Mucker; Steven A Kwilas; Gustavo Palacios; Jay W Hooper
Journal:  Sci Rep       Date:  2017-07-05       Impact factor: 4.379

Review 7.  Hemorrhagic Fever-Causing Arenaviruses: Lethal Pathogens and Potent Immune Suppressors.

Authors:  Morgan E Brisse; Hinh Ly
Journal:  Front Immunol       Date:  2019-03-13       Impact factor: 7.561

8.  A potent Lassa virus antiviral targets an arenavirus virulence determinant.

Authors:  Ikenna G Madu; Megan Files; Dima N Gharaibeh; Amy L Moore; Kie-Hoon Jung; Brian B Gowen; Dongcheng Dai; Kevin F Jones; Shanthakumar R Tyavanagimatt; James R Burgeson; Marcus J Korth; Kristin M Bedard; Shawn P Iadonato; Sean M Amberg
Journal:  PLoS Pathog       Date:  2018-12-21       Impact factor: 6.823

9.  Glycoprotein N-linked glycans play a critical role in arenavirus pathogenicity.

Authors:  Takaaki Koma; Cheng Huang; Adrian Coscia; Steven Hallam; John T Manning; Junki Maruyama; Aida G Walker; Milagros Miller; Jeanon N Smith; Michael Patterson; Jonathan Abraham; Slobodan Paessler
Journal:  PLoS Pathog       Date:  2021-03-01       Impact factor: 6.823

Review 10.  Animal Models for the Study of Rodent-Borne Hemorrhagic Fever Viruses: Arenaviruses and Hantaviruses.

Authors:  Joseph W Golden; Christopher D Hammerbeck; Eric M Mucker; Rebecca L Brocato
Journal:  Biomed Res Int       Date:  2015-07-21       Impact factor: 3.411
  10 in total

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