| Literature DB >> 8095307 |
Abstract
CD4+ cells derived from the human cell lines U87MG and SCL1 cannot be infected by human immunodeficiency virus type 1 (HIV-1) or fuse with cells expressing the HIV-1 envelope. This block was complemented in heterokaryons with HeLa cells and probably reflects the absence of cellular factors necessary for membrane fusion. Since U87MG cells expressing CD4 are permissive to HIV-2, distinct cellular factors could be required for fusion mediated by two related human retroviruses.Entities:
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Year: 1993 PMID: 8095307 PMCID: PMC240396
Source DB: PubMed Journal: J Virol ISSN: 0022-538X Impact factor: 5.103