Literature DB >> 2424612

Genetic variability of the AIDS virus: nucleotide sequence analysis of two isolates from African patients.

M Alizon, S Wain-Hobson, L Montagnier, P Sonigo.   

Abstract

To define further the genetic variability of the human AIDS retrovirus, we have cloned and sequenced the complete genomes of two isolates obtained from Zairian patients. Their genetic organization is identical with that of isolates from Europe and North America, confirming a common evolutionary origin. However, the comparison of homologous proteins from these different isolates reveals a much greater extent of genetic polymorphism than previously observed. It is nevertheless possible to define conserved domains in the viral proteins, especially in the envelope, that could be of interest for the understanding of the molecular mechanisms of viral pathogenicity and for the development of diagnostic and therapeutic reagents.

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Year:  1986        PMID： 2424612     DOI： 10.1016/0092-8674(86)90860-3

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  175 in total

1.  In vitro selection of ribozymes dependent on peptides for activity.

Authors:  Michael P Robertson; Scott M Knudsen; Andrew D Ellington
Journal:  RNA       Date:  2004-01       Impact factor: 4.942

2.  Regulation of the reverse transcriptase of human immunodeficiency virus type 1 by dNTPs.

Authors:  A B West; T M Roberts; R D Kolodner
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-15       Impact factor: 11.205

3.  Nonrandom distribution of gp120 N-linked glycosylation sites important for infectivity of human immunodeficiency virus type 1.

Authors:  W R Lee; W J Syu; B Du; M Matsuda; S Tan; A Wolf; M Essex; T H Lee
Journal:  Proc Natl Acad Sci U S A       Date:  1992-03-15       Impact factor: 11.205

4.  The visna virus genome: evidence for a hypervariable site in the env gene and sequence homology among lentivirus envelope proteins.

Authors:  M J Braun; J E Clements; M A Gonda
Journal:  J Virol       Date:  1987-12       Impact factor: 5.103

5.  Structural basis for transcriptional start site control of HIV-1 RNA fate.

Authors:  Joshua D Brown; Siarhei Kharytonchyk; Issac Chaudry; Aishwarya S Iyer; Hannah Carter; Ghazal Becker; Yash Desai; Lindsay Glang; Seung H Choi; Karndeep Singh; Michael W Lopresti; Matthew Orellana; Tatiana Rodriguez; Ubiomo Oboh; Jana Hijji; Frances Grace Ghinger; Kailan Stewart; Dillion Francis; Bryce Edwards; Patrick Chen; David A Case; Alice Telesnitsky; Michael F Summers
Journal:  Science       Date:  2020-04-24       Impact factor: 47.728

6.  Identification of single and dual infections with distinct subtypes of human immunodeficiency virus type 1 by using restriction fragment length polymorphism analysis.

Authors:  L M Janini; D Pieniazek; J M Peralta; M Schechter; A Tanuri; A C Vicente; N dela Torre; N J Pieniazek; C C Luo; M L Kalish; G Schochetman; M A Rayfield
Journal:  Virus Genes       Date:  1996       Impact factor: 2.332

7.  Characterization of genetic variation and 3'-azido-3'-deoxythymidine- resistance mutations of human immunodeficiency virus by the RNase A mismatch cleavage method.

Authors:  C López-Galíndez; J M Rojas; R Nájera; D D Richman; M Perucho
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-15       Impact factor: 11.205

8.  B- and T-lymphocyte responses to an immunodominant epitope of human immunodeficiency virus.

Authors:  R D Schrier; J W Gnann; A J Langlois; K Shriver; J A Nelson; M B Oldstone
Journal:  J Virol       Date:  1988-08       Impact factor: 5.103

9.  Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase.

Authors:  L M Mansky; H M Temin
Journal:  J Virol       Date:  1995-08       Impact factor: 5.103

10.  Molecular cloning of a novel isolate of feline immunodeficiency virus biologically and genetically different from the original U.S. isolate.

Authors:  T Miyazawa; M Fukasawa; A Hasegawa; N Maki; K Ikuta; E Takahashi; M Hayami; T Mikami
Journal:  J Virol       Date:  1991-03       Impact factor: 5.103
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