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Literature DB >> 6049931

The metabolism of phenethyl bromide, styrene and styrene oxide in the rabbit and rat.

Abstract

1. The chief sulphur-containing metabolite of styrene and sytrene oxide in the rabbit and rat is chromatographically identical with N-acetyl-S-(beta-hydroxyphenethyl)-l-cysteine and this compound is also formed, together with N-acetyl-S-phenethyl-l-cysteine, as a metabolite of phenethyl bromide. 2. The amounts of the phenethylmercapturic acid and its hydroxy derivative excreted in the urine of animals dosed with phenethyl bromide, styrene, styrene oxide, phenyl glycol, S-phenylethylcysteine and phenethylmercapturic acid have been determined. 3. Liver slices convert phenethylcysteine and phenethylmercapturic acid into N-acetyl-S-(beta-hydroxyphenethyl)-l-cysteine. 4. Methods for the determination by gas-liquid chromatography of mandelic acid and hippuric acid, which are metabolites of some of the compounds studied, are described.

Entities: Chemical Species

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Year: 1967 PMID： 6049931 PMCID： PMC1271233 DOI： 10.1042/bj1040914

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

17 in total

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Journal: Biochem J Date: 1954-02 Impact factor: 3.857

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Journal: Biochem J Date: 1952-11 Impact factor: 3.857

5. The biosynthesis of L-cystine and L-methionine labelled with radioactive sulphur (35S).

Authors: R B WILLIAMS; R M C DAWSON
Journal: Biochem J Date: 1952-10 Impact factor: 3.857

6. Formation of mercapturic acids. 5. Metabolism of some halogenoparaffins and nitroparaffins.

Authors: H G Bray; J C Caygill; S P James; P B Wood
Journal: Biochem J Date: 1964-01 Impact factor: 3.857

7. Biochemical studies of toxic agents. 15. The biosynthesis of ethylmercapturic acid sulphoxide.

Authors: E A Barnsley; A E Thomson; L Young
Journal: Biochem J Date: 1964-03 Impact factor: 3.857

8. Studies on glutathione S-alkyltransferase of the rat.

Authors: M K Johnson
Journal: Biochem J Date: 1966-01 Impact factor: 3.857

9. Separation of mercapturic acids and related compounds by gas chromatography and a method for the determination of hippuric acid.

Authors: S P James; R H Waring; D A White
Journal: J Chromatogr Date: 1967-01

10. Biochemical studies of toxic agents. The metabolism of 1- and 2-bromopropane in rats.

Authors: E A Barnsley; T H Grenby; L Young
Journal: Biochem J Date: 1966-07 Impact factor: 3.857

11 in total

1. Human exposure to styrene. I. The gaschromatographic determination of urinary phenylglyoxylic acid using diazomethane derivatization.

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Journal: Int Arch Occup Environ Health Date: 1976-04-28 Impact factor: 3.015

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Authors: J G Fernández; J R Caperos
Journal: Int Arch Occup Environ Health Date: 1977-10-17 Impact factor: 3.015

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Authors: R Husain; N F Zaidi; S P Srivastava; P K Seth
Journal: Bull Environ Contam Toxicol Date: 1985-05 Impact factor: 2.151

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Authors: M Ogata; R Sugihara
Journal: Int Arch Occup Environ Health Date: 1978-09-15 Impact factor: 3.015

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Authors: J R Caperos; B Humbert; P O Droz
Journal: Int Arch Occup Environ Health Date: 1979-01-15 Impact factor: 3.015

6. Simultaneous gas chromatographic determination of urinary mandelic and phenylglyoxylic acids using diazomethane derivatization.

Authors: J Flek; V Sedivec
Journal: Int Arch Occup Environ Health Date: 1980-02 Impact factor: 3.015