Literature DB >> 8091502

X-chromosome inactivation: molecular mechanisms and genetic consequences.

B R Migeon1.   

Abstract

Mammalian X-chromosome inactivation results in dosage compensation for X-linked genes. More than 30 years after its discovery, the molecular bases of this inactivation are being revealed. Multiple mechanisms are responsible for the initiation of this developmental event and the maintenance of the inactive state. Somatic cellular mosaicism, which is the genetic consequence of X-chromosome inactivation, has a profound influence on the phenotype of mammalian females.

Entities:  

Mesh：

Year:  1994        PMID： 8091502     DOI： 10.1016/0168-9525(94)90169-4

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  32 in total

1.  Antisense transcription through the Xist locus mediates Tsix function in embryonic stem cells.

Authors:  S Luikenhuis; A Wutz; R Jaenisch
Journal:  Mol Cell Biol       Date:  2001-12       Impact factor: 4.272

2.  Dynamic methylation adjustment and counting as part of imprinting mechanisms.

Authors:  R Shemer; Y Birger; W L Dean; W Reik; A D Riggs; A Razin
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-25       Impact factor: 11.205

3.  A DNA insulator prevents repression of a targeted X-linked transgene but not its random or imprinted X inactivation.

Authors:  Dominic Ciavatta; Sundeep Kalantry; Terry Magnuson; Oliver Smithies
Journal:  Proc Natl Acad Sci U S A       Date:  2006-06-15       Impact factor: 11.205

4.  The X chromosome is organized into a gene-rich outer rim and an internal core containing silenced nongenic sequences.

Authors:  Christine Moulton Clemson; Lisa L Hall; Meg Byron; John McNeil; Jeanne Bentley Lawrence
Journal:  Proc Natl Acad Sci U S A       Date:  2006-05-08       Impact factor: 11.205

5.  Structural adaptations in the interaction of EcoRI endonuclease with methylated GAATTC sites.

Authors:  L Jen-Jacobson; L E Engler; D R Lesser; M R Kurpiewski; C Yee; B McVerry
Journal:  EMBO J       Date:  1996-06-03       Impact factor: 11.598

6.  Comparative methylation analysis of murine transgenes that undergo or escape X-chromosome inactivation.

Authors:  M A Goldman; P S Reeves; C M Wirth; W J Zupko; M A Wong; S Edelhoff; C M Disteche
Journal:  Chromosome Res       Date:  1998-08       Impact factor: 5.239

7.  Differential underacetylation of histones H2A, H3 and H4 on the inactive X chromosome in human female cells.

Authors:  N Belyaev; A M Keohane; B M Turner
Journal:  Hum Genet       Date:  1996-05       Impact factor: 4.132

8.  Baculovirus-mediated expression and characterization of the full-length murine DNA methyltransferase.

Authors:  S Pradhan; D Talbot; M Sha; J Benner; L Hornstra; E Li; R Jaenisch; R J Roberts
Journal:  Nucleic Acids Res       Date:  1997-11-15       Impact factor: 16.971

9.  Connexin 32 mutations from X-linked Charcot-Marie-Tooth disease patients: functional defects and dominant negative effects.

Authors:  Y Omori; M Mesnil; H Yamasaki
Journal:  Mol Biol Cell       Date:  1996-06       Impact factor: 4.138

10.  Faithful chromosome transmission requires Spt4p, a putative regulator of chromatin structure in Saccharomyces cerevisiae.

Authors:  M A Basrai; J Kingsbury; D Koshland; F Spencer; P Hieter
Journal:  Mol Cell Biol       Date:  1996-06       Impact factor: 4.272
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