Literature DB >> 8223773

Initial experience with single-photon emission tomography using iodine-123-labelled 2 beta-carbomethoxy-3 beta-(4-iodophenyl) tropane in human brain.

J T Kuikka1, K A Bergström, E Vanninen, V Laulumaa, P Hartikainen, E Länsimies.   

Abstract

The iodinated cocaine analogue 2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane ([123I]beta-CIT), a new dopamine transporter, was preliminary tested in human brain. Two normal volunteers and two patients with Parkinson's disease were imaged with a high-resolution single-photon emission tomography scanner. The specific binding of [123I]beta-CIT in the basal ganglia and thalamus was high in normal volunteers. In addition, there was relatively intense uptake in the medial prefrontal area. Patients with Parkinson's disease who were older than controls showed significantly lower specific binding in the basal ganglia and thalamus and no uptake in the medial prefrontal cortex. This decrease in the dopamine transporter may be age related.

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Year:  1993        PMID： 8223773     DOI： 10.1007/bf00180909

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  9 in total

1.  Single photon emission computed tomography imaging of monoamine reuptake sites in primate brain with [123I]CIT.

Authors:  R Innis; R Baldwin; E Sybirska; Y Zea; M Laruelle; M al-Tikriti; D Charney; S Zoghbi; E Smith; G Wisniewski
Journal:  Eur J Pharmacol       Date:  1991-08-06       Impact factor: 4.432

2.  In vivo characterisation of 3-iodo-6-methoxybenzamide 123I in humans.

Authors:  D C Costa; N P Verhoeff; I D Cullum; P J Ell; G M Syed; J Barrett; E Palazidou; B Toone; E Van Royen; M Bobeldijk
Journal:  Eur J Nucl Med       Date:  1990

Review 3.  Dopamine transporter: biochemistry, pharmacology and imaging.

Authors:  M J Kuhar; P M Sanchez-Roa; D F Wong; R F Dannals; D E Grigoriadis; R Lew; M Milberger
Journal:  Eur Neurol       Date:  1990       Impact factor: 1.710

Review 4.  Where have we got to with neuroreceptor mapping of the human brain?

Authors:  B Mazière; M Mazière
Journal:  Eur J Nucl Med       Date:  1990

5.  Imaging of D2 dopamine receptors of patients with Parkinson's disease using single photon emission computed tomography and iodobenzamide I 123.

Authors:  V Laulumaa; J T Kuikka; H Soininen; K Bergström; E Länsimies; P Riekkinen
Journal:  Arch Neurol       Date:  1993-05

6.  SPECT imaging of dopamine and serotonin transporters with [123I]beta-CIT: pharmacological characterization of brain uptake in nonhuman primates.

Authors:  M Laruelle; R M Baldwin; R T Malison; Y Zea-Ponce; S S Zoghbi; M S al-Tikriti; E H Sybirska; R C Zimmermann; G Wisniewski; J L Neumeyer
Journal:  Synapse       Date:  1993-04       Impact factor: 2.562

7.  [123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane: high-affinity SPECT radiotracer of monoamine reuptake sites in brain.

Authors:  J L Neumeyer; S Y Wang; R A Milius; R M Baldwin; Y Zea-Ponce; P B Hoffer; E Sybirska; M al-Tikriti; D S Charney; R T Malison
Journal:  J Med Chem       Date:  1991-10       Impact factor: 7.446

8.  Evaluation of the monoamine uptake site ligand [123I]methyl 3 beta-(4-iodophenyl)-tropane-2 beta-carboxylate ([123I]beta-CIT) in non-human primates: pharmacokinetics, biodistribution and SPECT brain imaging coregistered with MRI.

Authors:  R M Baldwin; Y Zea-Ponce; S S Zoghbi; M Laurelle; M S al-Tikriti; E H Sybirska; R T Malison; J L Neumeyer; R A Milius; S Wang
Journal:  Nucl Med Biol       Date:  1993-07       Impact factor: 2.408

9.  Binding of the cocaine analog 2 beta-carbomethoxy-3 beta-(4-[125I]iodophenyl)tropane to serotonin and dopamine transporters: different ionic requirements for substrate and 2 beta-carbomethoxy-3 beta-(4-[125I]iodophenyl)tropane binding.

Authors:  S C Wall; R B Innis; G Rudnick
Journal:  Mol Pharmacol       Date:  1993-02       Impact factor: 4.436
  9 in total
  12 in total

1.  Cluster C personality disorder has no independent effect on striatal dopamine transporter densities in major depression.

Authors:  T Laasonen-Balk; H Viinamäki; J Kuikka; M Husso-Saastamoinen; J Lehtonen; P Halonen; J Tiihonen
Journal:  Psychopharmacology (Berl)       Date:  2001-04       Impact factor: 4.530

Review 2.  SPECT imaging evaluation in movement disorders: far beyond visual assessment.

Authors:  Kosmas Badiavas; Elisavet Molyvda; Ioannis Iakovou; Magdalini Tsolaki; Kyriakos Psarrakos; Nikolaos Karatzas
Journal:  Eur J Nucl Med Mol Imaging       Date:  2010-12-02       Impact factor: 9.236

3.  beta-CIT SPECT demonstrates blockade of 5HT-uptake sites by citalopram in the human brain in vivo.

Authors:  W Pirker; S Asenbaum; S Kasper; H Walter; P Angelberger; G Koch; A Pozzera; L Deecke; I Podreka; T Brücke
Journal:  J Neural Transm Gen Sect       Date:  1995

4.  In vitro and in vivo characterisation of nor-beta-CIT: a potential radioligand for visualisation of the serotonin transporter in the brain.

Authors:  K A Bergström; C Halldin; H Hall; C Lundkvist; N Ginovart; C G Swahn; L Farde
Journal:  Eur J Nucl Med       Date:  1997-06

Review 5.  Imaging the serotonin transporter during major depressive disorder and antidepressant treatment.

Authors:  Jeffrey H Meyer
Journal:  J Psychiatry Neurosci       Date:  2007-03       Impact factor: 6.186

6.  [123I] ADAM brainstem binding correlates with the loudness dependence of auditory evoked potentials.

Authors:  Oliver Pogarell; Walter Koch; Nadine Schaaff; Gabriele Pöpperl; Christoph Mulert; Georg Juckel; Hans-Jürgen Möller; Ulrich Hegerl; Klaus Tatsch
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2007-11-07       Impact factor: 5.270

7.  Comparison of [123I]beta-CIT and [123I]IPCIT as single-photon emission tomography radiotracers for the dopamine transporter in nonhuman primates.

Authors:  B E Scanley; M S al-Tikriti; M S Gandelman; M Laruelle; Y Zea-Ponce; R M Baldwin; S S Zoghbi; P B Hoffer; D S Charney; S Wang
Journal:  Eur J Nucl Med       Date:  1995-01

8.  The dosimetry of iodine-123 labelled 2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane.

Authors:  J T Kuikka; K A Bergström; A Ahonen; E Länsimies
Journal:  Eur J Nucl Med       Date:  1994-01

9.  Imaging of serotonin and dopamine transporters in the living human brain.

Authors:  J T Kuikka; J Tiihonen; K A Bergström; J Karhu; P Hartikainen; H Viinamäki; E Länsimies; J Lehtonen; P Hakola
Journal:  Eur J Nucl Med       Date:  1995-04

10.  Comparison of iodine-123 labelled 2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane and 2 beta-carbomethoxy-3 beta-(4-iodophenyl)-N-(3-fluoropropyl)nortropane for imaging of the dopamine transporter in the living human brain.

Authors:  J T Kuikka; K A Bergström; A Ahonen; J Hiltunen; J Haukka; E Länsimies; S Wang; J L Neumeyer
Journal:  Eur J Nucl Med       Date:  1995-04
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