| Literature DB >> 8075641 |
W H Berrettini1, T N Ferraro, R C Alexander, A M Buchberg, W H Vogel.
Abstract
Quantitative trait loci mapping was used to identify the chromosomal location of genes which contribute to oral morphine preference (in a two-bottle choice paradigm) of C57BL/6J mice, compared to DBA/2J mice. An F2 intercross of these two strains (606 mice) was phenotyped for morphine preference and those mice demonstrating extreme values for morphine consumption (the highest and lowest 7.7%) were genotyped for 157 murine microsatellite polymorphisms. Maximum likelihood methods revealed three loci on murine chromosomes 1, 6 and 10 which are responsible for nearly 85% of the genetic variance observed between the two parental strains.Entities:
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Year: 1994 PMID： 8075641 DOI： 10.1038/ng0594-54
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330