Literature DB >> 31133439

High-Diversity Mouse Populations for Complex Traits.

Michael C Saul1, Vivek M Philip1, Laura G Reinholdt1, Elissa J Chesler2.   

Abstract

Contemporary mouse genetic reference populations are a powerful platform to discover complex disease mechanisms. Advanced high-diversity mouse populations include the Collaborative Cross (CC) strains, Diversity Outbred (DO) stock, and their isogenic founder strains. When used in systems genetics and integrative genomics analyses, these populations efficiently harnesses known genetic variation for precise and contextualized identification of complex disease mechanisms. Extensive genetic, genomic, and phenotypic data are already available for these high-diversity mouse populations and a growing suite of data analysis tools have been developed to support research on diverse mice. This integrated resource can be used to discover and evaluate disease mechanisms relevant across species.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  complex genetics; complex traits; genetic diversity; mouse; systems genetics

Mesh：

Year:  2019        PMID： 31133439      PMCID： PMC6571031          DOI： 10.1016/j.tig.2019.04.003

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  111 in total

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