Literature DB >> 8067758

In vitro activities of furoquinoline and acridone alkaloids against Plasmodium falciparum.

L K Basco1, S Mitaku, A L Skaltsounis, N Ravelomanantsoa, F Tillequin, M Koch, J Le Bras.   

Abstract

The in vitro activities of furo[2,3b]quinoline and acridone alkaloids against Plasmodium falciparum were evaluated by an isotopic semimicrotest. A pyran ring in the furoquinoline nucleus and 2-O-pyranoglycoside and 2-nitro substituents in the acridone nucleus improved the antimalarial activities of the compounds. These findings provide a clue for further chemical modifications.

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Year:  1994        PMID： 8067758      PMCID： PMC188171          DOI： 10.1128/AAC.38.5.1169

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

1.  Synthesis and biological activity of acronycine analogs.

Authors:  J Schneider; E L Evans; E Grunberg; R I Fryer
Journal:  J Med Chem       Date:  1972-03       Impact factor: 7.446

2.  [Plants from New Caledonia. Alkaloids from Sarcomelicope dogniensis Hartley stem bark].

Authors:  S Mitaku; A L Skaltsounis; F Tillequin; M Koch; J Pusset
Journal:  Ann Pharm Fr       Date:  1989

3.  Activities of new acridone alkaloid derivatives against Plasmodium yoelii in vitro.

Authors:  H Fujioka; N Kato; M Fujita; K Fujimura; Y Nishiyama
Journal:  Arzneimittelforschung       Date:  1990-09

4.  Chemistry of Acronycine; Part 1. Synthesis of 1-Hydroxy-1,2-dihydroacronycine and 2-Hydroxy-1,2-dihydroacronycine.

Authors:  S Mitaku; A L Skaltsounis; F Tillequin; M Koch
Journal:  Planta Med       Date:  1988-02       Impact factor: 3.352

5.  In vitro activities of acridone alkaloids against Pneumocystis carinii.

Authors:  S F Queener; H Fujioka; Y Nishiyama; H Furukawa; M S Bartlett; J W Smith
Journal:  Antimicrob Agents Chemother       Date:  1991-02       Impact factor: 5.191

6.  Antimalarials. 1. Aminoalkylamino derivatives of 2,3-dihydrofuroquinolines.

Authors:  P A Cruickshank; F T Lee; A Lupichuk
Journal:  J Med Chem       Date:  1970-11       Impact factor: 7.446

7.  Human malaria parasites in continuous culture.

Authors:  W Trager; J B Jensen
Journal:  Science       Date:  1976-08-20       Impact factor: 47.728

8.  Alkaloids of Acronychia Baueri Schott I. Isolation of the alkaloids and a study of the antitumor and other biological properties of acronycine.

Authors:  G H Svoboda; G A Poore; P J Simpson; G B Boder
Journal:  J Pharm Sci       Date:  1966-08       Impact factor: 3.534

9.  In vitro study of drug sensitivity of Plasmodium falciparum: evaluation of a new semi-micro test.

Authors:  J Le Bras; P Deloron
Journal:  Am J Trop Med Hyg       Date:  1983-05       Impact factor: 2.345

10.  In vitro and in vivo activities of atalaphillinine and related acridone alkaloids against rodent malaria.

Authors:  H Fujioka; Y Nishiyama; H Furukawa; N Kumada
Journal:  Antimicrob Agents Chemother       Date:  1989-01       Impact factor: 5.191
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  23 in total

1.  Seaweeds as a source of lead compounds for the development of new antiplasmodial drugs from South East coast of India.

Authors:  Sundaram Ravikumar; Samuel Jacob Inbaneson; Palavesam Suganthi
Journal:  Parasitol Res       Date:  2010-12-29       Impact factor: 2.289

2.  Acridones and quinacridones: novel fluorophores for fluorescence lifetime studies.

Authors:  J Anthony Smith; Richard M West; Malcolm Allen
Journal:  J Fluoresc       Date:  2004-03       Impact factor: 2.217

3.  Antimalarial potential of leaves of Chenopodium ambrosioides L.

Authors:  Dalila Nunes Cysne; Thiare Silva Fortes; Aramys Silva Reis; Bruno de Paulo Ribeiro; Amália Dos Santos Ferreira; Flavia Maria Mendonça do Amaral; Rosane Nassar Meireles Guerra; Claudio Romero Farias Marinho; Roberto Nicolete; Flávia Raquel Fernandes Nascimento
Journal:  Parasitol Res       Date:  2016-08-05       Impact factor: 2.289

4.  Close the ring to break the cycle: tandem quinolone-alkyne-cyclisation gives access to tricyclic pyrrolo[1,2-a]quinolin-5-ones with potent anti-protozoal activity.

Authors:  Dávid Szamosvári; Kayla Sylvester; Philipp Schmid; Kuan-Yi Lu; Emily R Derbyshire; Thomas Böttcher
Journal:  Chem Commun (Camb)       Date:  2019-06-13       Impact factor: 6.222

5.  Acridone suppresses the proliferation of human breast cancer cells in vitro via ATP-binding cassette subfamily G member 2.

Authors:  Licheng Xu; Shuyan Li; Zhi Liang; Haixia Lin; Rongzhan Fu
Journal:  Oncol Lett       Date:  2017-12-11       Impact factor: 2.967

6.  Synthesis of o-(dimethylamino)aryl ketones and acridones by the reaction of 1,1-dialkylhydrazones and arynes.

Authors:  Anton V Dubrovskiy; Richard C Larock
Journal:  Org Lett       Date:  2011-07-11       Impact factor: 6.005

7.  (R)-(+)-Dimeth-yl[4-oxido-2-oxo-1-(1-phenyl-eth-yl)-1,2,5,6-tetra-hydro-pyridin-3-yl]sulfonium.

Authors:  Paola G Gordillo; Joel L Terán; Jorge R Juárez; Angel Mendoza
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-01-08

8.  Enhanced antimalarial effects of chloroquine by aqueous Vernonia amygdalina leaf extract in mice infected with chloroquine resistant and sensitive Plasmodium berghei strains.

Authors:  B A Iwalokun
Journal:  Afr Health Sci       Date:  2008-03       Impact factor: 0.927

9.  Synthesis of o-(dimethylamino)aryl ketones, acridones, acridinium salts, and 1H-indazoles by the reaction of hydrazones and arynes.

Authors:  Anton V Dubrovskiy; Richard C Larock
Journal:  J Org Chem       Date:  2012-12-03       Impact factor: 4.354

Review 10.  Microbial transformations of antimicrobial quinolones and related drugs.

Authors:  Igor A Parshikov; John B Sutherland
Journal:  J Ind Microbiol Biotechnol       Date:  2012-09-25       Impact factor: 3.346
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