Literature DB >> 2024971

In vitro activities of acridone alkaloids against Pneumocystis carinii.

S F Queener1, H Fujioka, Y Nishiyama, H Furukawa, M S Bartlett, J W Smith.   

Abstract

Acridone alkaloids isolated from plants of the family Rutaceae have antiplasmodial activity in rodent models of malaria. Because a variety of antimalarial agents have also been shown to have activity against Pneumocystis carinii, we tested six of these alkaloids in an established culture model for P. carinii. Atalaphillinine and glycobismine A inhibited growth of cultured P. carinii at concentrations of 2.7 and 1.7 microM, respectively. This potency of effect is similar to that of chloroquine (3 microM) but somewhat less than that of primaquine (0.4 microM), which was previously evaluated in the same system.

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Year:  1991        PMID： 2024971      PMCID： PMC245010          DOI： 10.1128/AAC.35.2.377

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

Review 1.  Quinoline, quinazoline, and acridone alkaloids.

Authors:  M F Grundon
Journal:  Nat Prod Rep       Date:  1988-06       Impact factor: 13.423

2.  Effects of the antineoplastic alkaloid acronycine on the ultrastructure and growth patterns of cultured cells.

Authors:  P Tan; N Auersperg
Journal:  Cancer Res       Date:  1973-10       Impact factor: 12.701

3.  Synthesis and biological activity of acronycine analogs.

Authors:  J Schneider; E L Evans; E Grunberg; R I Fryer
Journal:  J Med Chem       Date:  1972-03       Impact factor: 7.446

4.  Latent Pneumocystis infection of rats, relapse, and chemotherapy.

Authors:  J K Frenkel; J T Good; J A Shultz
Journal:  Lab Invest       Date:  1966-10       Impact factor: 5.662

5.  Antimicrobial susceptibility of Pneumocystis carinii in culture.

Authors:  M S Bartlett; R Eichholtz; J W Smith
Journal:  Diagn Microbiol Infect Dis       Date:  1985-09       Impact factor: 2.803

6.  In vitro effects of antiprotozoan drugs and immune serum on Pneumocystis carinii.

Authors:  E L Pesanti
Journal:  J Infect Dis       Date:  1980-06       Impact factor: 5.226

7.  Activity of clindamycin with primaquine against Pneumocystis carinii in vitro and in vivo.

Authors:  S F Queener; M S Bartlett; J D Richardson; M M Durkin; M A Jay; J W Smith
Journal:  Antimicrob Agents Chemother       Date:  1988-06       Impact factor: 5.191

8.  Pneumocystis carinii: improved models to study efficacy of drugs for treatment or prophylaxis of Pneumocystis pneumonia in the rat (Rattus spp.).

Authors:  M S Bartlett; J A Fishman; M M Durkin; S F Queener; J W Smith
Journal:  Exp Parasitol       Date:  1990-01       Impact factor: 2.011

9.  Alkaloids of Acronychia Baueri Schott I. Isolation of the alkaloids and a study of the antitumor and other biological properties of acronycine.

Authors:  G H Svoboda; G A Poore; P J Simpson; G B Boder
Journal:  J Pharm Sci       Date:  1966-08       Impact factor: 3.534

10.  In vitro and in vivo activities of atalaphillinine and related acridone alkaloids against rodent malaria.

Authors:  H Fujioka; Y Nishiyama; H Furukawa; N Kumada
Journal:  Antimicrob Agents Chemother       Date:  1989-01       Impact factor: 5.191
  10 in total
  8 in total

1.  Activity and mode of action of acridine compounds against Leishmania donovani.

Authors:  C M Mesa-Valle; J Castilla-Calvente; M Sanchez-Moreno; V Moraleda-Lindez; J Barbe; A Osuna
Journal:  Antimicrob Agents Chemother       Date:  1996-03       Impact factor: 5.191

2.  Identification of a class of sulfonamides highly active against dihydropteroate synthase form Toxoplasma gondii, Pneumocystis carinii, and Mycobacterium avium.

Authors:  L C Chio; L A Bolyard; M Nasr; S F Queener
Journal:  Antimicrob Agents Chemother       Date:  1996-03       Impact factor: 5.191

3.  Structure-activity and structure-selectivity studies on diaminoquinazolines and other inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.

Authors:  A Rosowsky; J B Hynes; S F Queener
Journal:  Antimicrob Agents Chemother       Date:  1995-01       Impact factor: 5.191

4.  Evaluation of potent inhibitors of dihydrofolate reductase in a culture model for growth of Pneumocystis carinii.

Authors:  M S Bartlett; M Shaw; P Navaran; J W Smith; S F Queener
Journal:  Antimicrob Agents Chemother       Date:  1995-11       Impact factor: 5.191

5.  8-aminoquinolines effective against Pneumocystis carinii in vitro and in vivo.

Authors:  S F Queener; M S Bartlett; M Nasr; J W Smith
Journal:  Antimicrob Agents Chemother       Date:  1993-10       Impact factor: 5.191

6.  Molecular cloning and heterologous expression of acridone synthase from elicited Ruta graveolens L. cell suspension cultures.

Authors:  K T Junghanns; R E Kneusel; A Baumert; W Maier; D Gröger; U Matern
Journal:  Plant Mol Biol       Date:  1995-02       Impact factor: 4.076

7.  In vitro activities of furoquinoline and acridone alkaloids against Plasmodium falciparum.

Authors:  L K Basco; S Mitaku; A L Skaltsounis; N Ravelomanantsoa; F Tillequin; M Koch; J Le Bras
Journal:  Antimicrob Agents Chemother       Date:  1994-05       Impact factor: 5.191

8.  Heterocycle-Fused Acridines.

Authors:  Paul W Groundwater; Munawar Ali Munawar
Journal:  Adv Heterocycl Chem       Date:  2008-04-25       Impact factor: 3.552
  8 in total

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