Literature DB >> 8065920

Sequence-specific interaction of alpha-beta-anomeric double-stranded DNA with the p50 subunit of NF kappa B: application to the decoy approach.

H Tanaka1, P Vickart, J R Bertrand, B Rayner, F Morvan, J L Imbach, D Paulin, C Malvy.   

Abstract

The potential use of alpha-beta-anomeric duplex oligonucleotides to inhibit transcription factor activity by the decoy approach is investigated in this report. Indeed, several alpha-beta-anomeric heteroduplexes display a sequence-specific interaction with the p50 subunit of the transcription factor NF kappa B. Used in a decoy approach, these duplexes interact strongly enough with this transcription factor to modulate the expression of a reporter gene, under the control of NF kappa B. However, all the alpha-beta-anomeric heteroduplexes do not interact with the p50 subunit; the sequence of the chirally natural beta-anomeric strand may explain the different recognition properties of the protein. The analysis of the appropriate beta-anomeric sequences is consistent with a preferential interaction of the p50 subunit with one strand of double-stranded DNA.

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Year:  1994        PMID： 8065920      PMCID： PMC310277          DOI： 10.1093/nar/22.15.3069

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  27 in total

1.  Rate of degradation of [alpha]- and [beta]-oligodeoxynucleotides in Xenopus oocytes. Implications for anti-messenger strategies.

Authors:  C Cazenave; M Chevrier; T T Nguyen; C Hélène
Journal:  Nucleic Acids Res       Date:  1987-12-23       Impact factor: 16.971

2.  alpha-DNA. VI: Comparative study of alpha- and beta-anomeric oligodeoxyribonucleotides in hybridization to mRNA and in cell free translation inhibition.

Authors:  C Gagnor; J R Bertrand; S Thenet; M Lemaître; F Morvan; B Rayner; C Malvy; B Lebleu; J L Imbach; C Paoletti
Journal:  Nucleic Acids Res       Date:  1987-12-23       Impact factor: 16.971

3.  Alpha-anomeric DNA: beta-RNA hybrids as new synthetic inhibitors of Escherichia coli RNase H, Drosophila embryo RNase H and M-MLV reverse transcriptase.

Authors:  E Bloch; M Lavignon; J R Bertrand; F Pognan; F Morvan; C Malvy; B Rayner; J L Imbach; C Paoletti
Journal:  Gene       Date:  1988-12-10       Impact factor: 3.688

4.  High-efficiency transformation of mammalian cells by plasmid DNA.

Authors:  C Chen; H Okayama
Journal:  Mol Cell Biol       Date:  1987-08       Impact factor: 4.272

5.  alpha-DNA. VII. Solid phase synthesis of alpha-anomeric oligodeoxyribonucleotides.

Authors:  F Morvan; B Rayner; J P Leonetti; J L Imbach
Journal:  Nucleic Acids Res       Date:  1988-02-11       Impact factor: 16.971

6.  Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase.

Authors:  D B Smith; K S Johnson
Journal:  Gene       Date:  1988-07-15       Impact factor: 3.688

7.  Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

Authors:  C M Gorman; L F Moffat; B H Howard
Journal:  Mol Cell Biol       Date:  1982-09       Impact factor: 4.272

8.  alpha-DNA. I. Synthesis, characterization by high field 1H-NMR, and base-pairing properties of the unnatural hexadeoxyribonucleotide alpha-[d(CpCpTpTpCpC)] with its complement beta-[d(GpGpApApGpG)].

Authors:  F Morvan; B Rayner; J L Imbach; D K Chang; J W Lown
Journal:  Nucleic Acids Res       Date:  1986-06-25       Impact factor: 16.971

9.  A quantitative analysis of nuclear factor I/DNA interactions.

Authors:  M Meisterernst; I Gander; L Rogge; E L Winnacker
Journal:  Nucleic Acids Res       Date:  1988-05-25       Impact factor: 16.971

Review 10.  Rational design of sequence-specific oncogene inhibitors based on antisense and antigene oligonucleotides.

Authors:  C Hélène
Journal:  Eur J Cancer       Date:  1991       Impact factor: 9.162
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  7 in total

1.  Sequence-independent inhibition of RNA transcription by DNA dumbbells and other decoys.

Authors:  C S Lim; N Jabrane-Ferrat; J D Fontes; H Okamoto; M R Garovoy; B M Peterlin; C A Hunt
Journal:  Nucleic Acids Res       Date:  1997-02-01       Impact factor: 16.971

2.  S100beta induction of the proinflammatory cytokine interleukin-6 in neurons.

Authors:  Y Li; S W Barger; L Liu; R E Mrak; W S Griffin
Journal:  J Neurochem       Date:  2000-01       Impact factor: 5.372

3.  Decoy approach using RNA-DNA chimera oligonucleotides to inhibit the regulatory function of human immunodeficiency virus type 1 Rev protein.

Authors:  T Nakaya; S Iwai; K Fujinaga; Y Sato; E Otsuka; K Ikuta
Journal:  Antimicrob Agents Chemother       Date:  1997-02       Impact factor: 5.191

4.  Phosphorothioate oligonucleotides derived from human immunodeficiency virus type 1 (HIV-1) primer tRNALys3 are strong inhibitors of HIV-1 reverse transcriptase and arrest viral replication in infected cells.

Authors:  R El Dirani-Diab; L Sarih-Cottin; B Delord; B Dumon; S Moreau; J J Toulme; H Fleury; S Litvak
Journal:  Antimicrob Agents Chemother       Date:  1997-10       Impact factor: 5.191

5.  Anomeric DNA Strand Displacement with α-D Oligonucleotides as Invaders and Ethidium Bromide as Fluorescence Sensor for Duplexes with α/β-, β/β- and α/α-D Configuration.

Authors:  Aigui Zhang; Dasharath Kondhare; Peter Leonard; Frank Seela
Journal:  Chemistry       Date:  2022-07-04       Impact factor: 5.020

6.  In vivo reduction of the nuclear factor-kappaB activity using synthetic cis-element decoy oligonucleotides suppresses intimal hyperplasia in the injured carotid arteries in rabbits.

Authors:  Kensuke Takeuchi; Hiroyuki Itoh; Yoshikazu Yonemitsu; Takuya Matsumoto; Masazumi Kume; Kimihiro Komori; Yoshihiko Maehara
Journal:  Surg Today       Date:  2007-06-26       Impact factor: 2.540

7.  Anomeric DNA: Functionalization of α-d Anomers of 7-Deaza-2'-deoxyadenosine and 2'-Deoxyuridine with Clickable Side Chains and Click Adducts in Homochiral and Heterochiral Double Helices.

Authors:  Aigui Zhang; Peter Leonard; Frank Seela
Journal:  Chemistry       Date:  2022-01-14       Impact factor: 5.020
  7 in total

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