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Literature DB >> 8058725

Design and synthesis of deoxynucleic guanidine: a polycation analogue of DNA.

Abstract

The basic strategy is described for the connection of nucleosides by guanidinium (g) linkers to provide the positively charged deoxynucleic guanidine putative antigene agents. The synthetic procedures are provided for d(gT)n. Molecular modeling of double-stranded [d(gT)10.d(Ap)10] and the triple-helical hybrids [d(Tp)10.d(Ap)10.d(gT)10] and [d(gT)10.d(Ap)10.d(gT)10] suggest modes of interaction and anticipated structural features.

Entities: Chemical

Mesh：

Substances：

Year: 1994 PMID： 8058725 PMCID： PMC44504 DOI： 10.1073/pnas.91.17.7864

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

5 in total

1. Molecular structure of a deoxyribose-dinucleotide, sodium thymidylyl-(5' yields to 3')-thymidylate-(5') hydrate (pTpT), and a possible structural model for polythymidylate.

Authors: N Camerman; J K Fawcett; A Cameran
Journal: J Mol Biol Date: 1976-11-15 Impact factor: 5.469

2. Nucleotide synthesis. IV. Phosphorylated 3'-amino-3'-deoxythymidine and 5'-amino-5'-deoxythymidine and derivatives.

Authors: R P Glinski; M S Khan; R L Kalamas; M B Sporn
Journal: J Org Chem Date: 1973-12-14 Impact factor: 4.354

3. Symmetry and molecular structure of a DNA triple helix: d(T)n.d(A)n.d(T)n.

Authors: G Raghunathan; H T Miles; V Sasisekharan
Journal: Biochemistry Date: 1993-01-19 Impact factor: 3.162

4. Synthesis and in vitro pharmacology of arpromidine and related phenyl(pyridylalkyl)guanidines, a potential new class of positive inotropic drugs.

Authors: A Buschauer
Journal: J Med Chem Date: 1989-08 Impact factor: 7.446

5. Peptide nucleic acid (PNA) conformation and polymorphism in PNA-DNA and PNA-RNA hybrids.

Authors: O Almarsson; T C Bruice
Journal: Proc Natl Acad Sci U S A Date: 1993-10-15 Impact factor: 11.205

5 in total

10 in total

Review 1. The design of guanidinium-rich transporters and their internalization mechanisms.

Authors: Paul A Wender; Wesley C Galliher; Elena A Goun; Lisa R Jones; Thomas H Pillow
Journal: Adv Drug Deliv Rev Date: 2007-11-09 Impact factor: 15.470

2. Mercury-Free Automated Synthesis of Guanidinium Backbone Oligonucleotides.

Authors: Kacper Skakuj; Katherine E Bujold; Chad A Mirkin
Journal: J Am Chem Soc Date: 2019-12-16 Impact factor: 15.419

3. Solid-phase synthesis of oligopurine deoxynucleic guanidine (DNG) and analysis of binding with DNA oligomers.

Authors: B A Linkletter; I E Szabo; T C Bruice
Journal: Nucleic Acids Res Date: 2001-06-01 Impact factor: 16.971

4. Beyond Cell Penetrating Peptides: Designed Molecular Transporters.

Authors: Paul A Wender; Christina B Cooley; Erika I Geihe
Journal: Drug Discov Today Technol Date: 2012

5. Binding studies of cationic thymidyl deoxyribonucleic guanidine to RNA homopolynucleotides.

Authors: K A Browne; R O Dempcy; T C Bruice
Journal: Proc Natl Acad Sci U S A Date: 1995-07-18 Impact factor: 11.205

6. Synthesis of a thymidyl pentamer of deoxyribonucleic guanidine and binding studies with DNA homopolynucleotides.

Authors: R O Dempcy; K A Browne; T C Bruice
Journal: Proc Natl Acad Sci U S A Date: 1995-06-20 Impact factor: 11.205

7. Fifteen years of cell-penetrating, guanidinium-rich molecular transporters: basic science, research tools, and clinical applications.

Authors: Erika Geihe Stanzl; Brian M Trantow; Jessica R Vargas; Paul A Wender
Journal: Acc Chem Res Date: 2013-05-22 Impact factor: 22.384