Literature DB >> 8633064

Design and synthesis of ribonucleic guanidine: a polycationic analog of RNA.

R O Dempcy1, J Luo, T C Bruice.   

Abstract

Replacement of the phosphodiester linkages of the polyanion RNA with guanidinium linkers (represented by g) provides the polycation ribonucleic guanidine (RNG). An anticipated structure for the triple-helical hybrid [r(Up)9U.r(Ag)9A.r(Up)9U] is presented. A basic strategy for the synthesis of RNG oligomers is described. Synthetic procedures are provided for tetrameric adenosyl RNG [r(Ag)3A].

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Year:  1996        PMID： 8633064      PMCID： PMC39535          DOI： 10.1073/pnas.93.9.4326

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  4 in total

1.  Binding studies of cationic thymidyl deoxyribonucleic guanidine to RNA homopolynucleotides.

Authors:  K A Browne; R O Dempcy; T C Bruice
Journal:  Proc Natl Acad Sci U S A       Date:  1995-07-18       Impact factor: 11.205

2.  Synthesis of a thymidyl pentamer of deoxyribonucleic guanidine and binding studies with DNA homopolynucleotides.

Authors:  R O Dempcy; K A Browne; T C Bruice
Journal:  Proc Natl Acad Sci U S A       Date:  1995-06-20       Impact factor: 11.205

3.  Design and synthesis of deoxynucleic guanidine: a polycation analogue of DNA.

Authors:  R O Dempcy; O Almarsson; T C Bruice
Journal:  Proc Natl Acad Sci U S A       Date:  1994-08-16       Impact factor: 11.205

4.  Structure of the B-DNA decamer C-C-A-A-C-G-T-T-G-G and comparison with isomorphous decamers C-C-A-A-G-A-T-T-G-G and C-C-A-G-G-C-C-T-G-G.

Authors:  G G Privé; K Yanagi; R E Dickerson
Journal:  J Mol Biol       Date:  1991-01-05       Impact factor: 5.469
  4 in total
  3 in total

1.  Synthesis, biophysical properties, and nuclease resistance properties of mixed backbone oligodeoxynucleotides containing cationic internucleoside guanidinium linkages: deoxynucleic guanidine/DNA chimeras.

Authors:  D A Barawkar; T C Bruice
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-15       Impact factor: 11.205

2.  Inhibition of Escherichia coli glycosyltransferase MurG and Mycobacterium tuberculosis Gal transferase by uridine-linked transition state mimics.

Authors:  Amy E Trunkfield; Sudagar S Gurcha; Gurdyal S Besra; Timothy D H Bugg
Journal:  Bioorg Med Chem       Date:  2010-02-19       Impact factor: 3.641

Review 3.  Oligonucleotide analogues with cationic backbone linkages.

Authors:  Melissa Meng; Christian Ducho
Journal:  Beilstein J Org Chem       Date:  2018-06-04       Impact factor: 2.883
  3 in total

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