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Literature DB >> 22712022

Beyond Cell Penetrating Peptides: Designed Molecular Transporters.

Paul A Wender¹, Christina B Cooley, Erika I Geihe.

Abstract

Inspired originally by peptides that traverse biological barriers, research on molecular transporters has since identified the key structural requirements that govern cellular entry, leading to new, significantly more effective and more readily available agents. These new drug delivery systems enable or enhance cellular and tissue uptake, can be targeted, and provide numerous additional advantages of significance in imaging, diagnostics and therapy.

Entities: CellLine Chemical Disease Gene Species

Year: 2012 PMID： 22712022 PMCID： PMC3375703 DOI： 10.1016/j.ddtec.2011.07.004

Source DB: PubMed Journal: Drug Discov Today Technol ISSN： 1740-6749

45 in total

1. Dendritic oligoguanidines as intracellular translocators.

Authors: Hyun-Ho Chung; Guido Harms; Churl Min Seong; Byung Hyune Choi; Changhee Min; Joseph P Taulane; Murray Goodman
Journal: Biopolymers Date: 2004 Impact factor: 2.505

2. Nucleic acid with guanidinium modification exhibits efficient cellular uptake.

Authors: Tatsuo Ohmichi; Masayasu Kuwahara; Naoko Sasaki; Masatoshi Hasegawa; Takahito Nishikata; Hiroaki Sawai; Naoki Sugimoto
Journal: Angew Chem Int Ed Engl Date: 2005-10-21 Impact factor: 15.336

Review 3. The design of guanidinium-rich transporters and their internalization mechanisms.

Authors: Paul A Wender; Wesley C Galliher; Elena A Goun; Lisa R Jones; Thomas H Pillow
Journal: Adv Drug Deliv Rev Date: 2007-11-09 Impact factor: 15.470

4. Molecular transporters for peptides: delivery of a cardioprotective epsilonPKC agonist peptide into cells and intact ischemic heart using a transport system, R(7).

Authors: L Chen; L R Wright; C H Chen; S F Oliver; P A Wender; D Mochly-Rosen
Journal: Chem Biol Date: 2001-12

5. Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein.

Authors: M Green; P M Loewenstein
Journal: Cell Date: 1988-12-23 Impact factor: 41.582

6. Oligocarbamate molecular transporters: design, synthesis, and biological evaluation of a new class of transporters for drug delivery.

Authors: Paul A Wender; Jonathan B Rothbard; Theodore C Jessop; Erik L Kreider; Bryan L Wylie
Journal: J Am Chem Soc Date: 2002-11-13 Impact factor: 15.419

7. Tumor imaging by means of proteolytic activation of cell-penetrating peptides.

Authors: Tao Jiang; Emilia S Olson; Quyen T Nguyen; Melinda Roy; Patricia A Jennings; Roger Y Tsien
Journal: Proc Natl Acad Sci U S A Date: 2004-12-15 Impact factor: 11.205

Review 8. Function-oriented synthesis, step economy, and drug design.

Authors: Paul A Wender; Vishal A Verma; Thomas J Paxton; Thomas H Pillow
Journal: Acc Chem Res Date: 2007-12-27 Impact factor: 22.384

9. Cellular uptake of aminoglycosides, guanidinoglycosides, and poly-arginine.

Authors: Nathan W Luedtke; Peter Carmichael; Yitzhak Tor
Journal: J Am Chem Soc Date: 2003-10-15 Impact factor: 15.419

10. Delivery of antimicrobials into parasites.

Authors: B U Samuel; B Hearn; D Mack; P Wender; J Rothbard; M J Kirisits; E Mui; S Wernimont; C W Roberts; S P Muench; D W Rice; S T Prigge; A B Law; R McLeod
Journal: Proc Natl Acad Sci U S A Date: 2003-11-17 Impact factor: 11.205

16 in total

1. Toward the Ideal Synthesis and Transformative Therapies: The Roles of Step Economy and Function Oriented Synthesis.

Authors: Paul A Wender
Journal: Tetrahedron Date: 2013-06-07 Impact factor: 2.457

Review 2. Current Transport Systems and Clinical Applications for Small Interfering RNA (siRNA) Drugs.

Authors: Fang Liu; Chunfang Wang; Yuantao Gao; Xiao Li; Feng Tian; Yongtao Zhang; Mingyang Fu; Pengfei Li; Yali Wang; Fei Wang
Journal: Mol Diagn Ther Date: 2018-10 Impact factor: 4.074

3. A molecular method for the delivery of small molecules and proteins across the cell wall of algae using molecular transporters.

Authors: Joel M Hyman; Erika I Geihe; Brian M Trantow; Bahram Parvin; Paul A Wender
Journal: Proc Natl Acad Sci U S A Date: 2012-07-30 Impact factor: 11.205

4. Designed guanidinium-rich amphipathic oligocarbonate molecular transporters complex, deliver and release siRNA in cells.

Authors: Erika I Geihe; Christina B Cooley; Jeff R Simon; Matthew K Kiesewetter; Justin A Edward; Robyn P Hickerson; Roger L Kaspar; James L Hedrick; Robert M Waymouth; Paul A Wender
Journal: Proc Natl Acad Sci U S A Date: 2012-07-30 Impact factor: 11.205

5. Guanidinium-rich, glycerol-derived oligocarbonates: a new class of cell-penetrating molecular transporters that complex, deliver, and release siRNA.

Authors: Paul A Wender; Melanie A Huttner; Daryl Staveness; Jessica R Vargas; Adele F Xu
Journal: Mol Pharm Date: 2015-01-27 Impact factor: 4.939

6. Cell-Penetrating, Guanidinium-Rich Oligophosphoesters: Effective and Versatile Molecular Transporters for Drug and Probe Delivery.

Authors: Colin J McKinlay; Robert M Waymouth; Paul A Wender
Journal: J Am Chem Soc Date: 2016-03-07 Impact factor: 15.419

10. Fifteen years of cell-penetrating, guanidinium-rich molecular transporters: basic science, research tools, and clinical applications.

Authors: Erika Geihe Stanzl; Brian M Trantow; Jessica R Vargas; Paul A Wender
Journal: Acc Chem Res Date: 2013-05-22 Impact factor: 22.384