Literature DB >> 8057465

Involvement of the cyclic AMP-responsive element binding protein in bovine leukemia virus expression in vivo.

E Adam1, P Kerkhofs, M Mammerickx, R Kettmann, A Burny, L Droogmans, L Willems.   

Abstract

The TAR element (Tax-responsive element; also called TxRE) is a major determinant of the regulation of bovine leukemia virus (BLV) expression. In order to gain insight into the mechanisms of viral expression, complexes formed between proteins and the TAR enhancer DNA were analyzed by gel retardation assays. We report here that nuclear lysates from ex vivo-isolated B lymphocytes contain proteins that specifically bind to TAR. An antibody directed toward the cyclic AMP-responsive element binding (CREB) protein supershifted a complex (C1) present only in BLV-infected B lymphocytes. The CREB protein thus appears to be a major transcription factor involved in BLV expression in vivo.

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Year:  1994        PMID： 8057465      PMCID： PMC236989     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  48 in total

1.  Molecular cloning of an enhancer binding protein: isolation by screening of an expression library with a recognition site DNA.

Authors:  H Singh; J H LeBowitz; A S Baldwin; P A Sharp
Journal:  Cell       Date:  1988-02-12       Impact factor: 41.582

Review 2.  Cyclic AMP and the induction of eukaryotic gene transcription.

Authors:  W J Roesler; G R Vandenbark; R W Hanson
Journal:  J Biol Chem       Date:  1988-07-05       Impact factor: 5.157

3.  Adenoviral control regions activated by E1A and the cAMP response element bind to the same factor.

Authors:  S Hardy; T Shenk
Journal:  Proc Natl Acad Sci U S A       Date:  1988-06       Impact factor: 11.205

4.  Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB.

Authors:  K K Yamamoto; G A Gonzalez; W H Biggs; M R Montminy
Journal:  Nature       Date:  1988-08-11       Impact factor: 49.962

5.  Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements.

Authors:  W Lee; P Mitchell; R Tjian
Journal:  Cell       Date:  1987-06-19       Impact factor: 41.582

6.  The correlation between the direct and indirect detection of bovine leukemia virus infection in cattle.

Authors:  G L Cockerell; J Rovnak
Journal:  Leuk Res       Date:  1988       Impact factor: 3.156

7.  HTLV-I Tax protein stimulation of DNA binding of bZIP proteins by enhancing dimerization.

Authors:  S Wagner; M R Green
Journal:  Science       Date:  1993-10-15       Impact factor: 47.728

8.  Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene.

Authors:  M R Montminy; L M Bilezikjian
Journal:  Nature       Date:  1987 Jul 9-15       Impact factor: 49.962

9.  Interaction of a common cellular transcription factor, ATF, with regulatory elements in both E1a- and cyclic AMP-inducible promoters.

Authors:  Y S Lin; M R Green
Journal:  Proc Natl Acad Sci U S A       Date:  1988-05       Impact factor: 11.205

10.  The bovine leukemia virus p34 is a transactivator protein.

Authors:  L Willems; A Gegonne; G Chen; A Burny; R Kettmann; J Ghysdael
Journal:  EMBO J       Date:  1987-11       Impact factor: 11.598
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  26 in total

1.  Discordance between bovine leukemia virus tax immortalization in vitro and oncogenicity in vivo.

Authors:  J C Twizere; P Kerkhofs; A Burny; D Portetelle; R Kettmann; L Willems
Journal:  J Virol       Date:  2000-11       Impact factor: 5.103

2.  Suboptimal enhancer sequences are required for efficient bovine leukemia virus propagation in vivo: implications for viral latency.

Authors:  C Merezak; C Pierreux; E Adam; F Lemaigre; G G Rousseau; C Calomme; C Van Lint; D Christophe; P Kerkhofs; A Burny; R Kettmann; L Willems
Journal:  J Virol       Date:  2001-08       Impact factor: 5.103

3.  Prostaglandin E2-Induced Immune Exhaustion and Enhancement of Antiviral Effects by Anti-PD-L1 Antibody Combined with COX-2 Inhibitor in Bovine Leukemia Virus Infection.

Authors:  Yamato Sajiki; Satoru Konnai; Tomohiro Okagawa; Asami Nishimori; Naoya Maekawa; Shinya Goto; Kei Watari; Erina Minato; Atsushi Kobayashi; Junko Kohara; Shinji Yamada; Mika K Kaneko; Yukinari Kato; Hirofumi Takahashi; Nobuhiro Terasaki; Akira Takeda; Keiichi Yamamoto; Mikihiro Toda; Yasuhiko Suzuki; Shiro Murata; Kazuhiko Ohashi
Journal:  J Immunol       Date:  2019-07-31       Impact factor: 5.422

4.  Prostaglandin E(2) increases bovine leukemia virus tax and pol mRNA levels via cyclooxygenase 2: regulation by interleukin-2, interleukin-10, and bovine leukemia virus.

Authors:  D Pyeon; F J Diaz; G A Splitter
Journal:  J Virol       Date:  2000-06       Impact factor: 5.103

5.  CD5 is dissociated from the B-cell receptor in B cells from bovine leukemia virus-infected, persistently lymphocytotic cattle: consequences to B-cell receptor-mediated apoptosis.

Authors:  G H Cantor; S M Pritchard; F Dequiedt; L Willems; R Kettmann; W C Davis
Journal:  J Virol       Date:  2001-02       Impact factor: 5.103

6.  Defibrinated bovine plasma inhibits retroviral transcription by blocking p52 activation of the NFkappaB element in the long terminal repeat.

Authors:  Marianne J van den Heuvel; Karen F Copeland; Elizabeth C Cates; Barbara J Jefferson; Robert M Jacobs
Journal:  Can J Vet Res       Date:  2007-04       Impact factor: 1.310

7.  An interferon regulatory factor binding site in the U5 region of the bovine leukemia virus long terminal repeat stimulates Tax-independent gene expression.

Authors:  V Kiermer; C Van Lint; D Briclet; C Vanhulle; R Kettmann; E Verdin; A Burny; L Droogmans
Journal:  J Virol       Date:  1998-07       Impact factor: 5.103

8.  Cellular pathways involved in the ex vivo expression of bovine leukemia virus.

Authors:  P Kerkhofs; E Adam; L Droogmans; D Portetelle; M Mammerickx; A Burny; R Kettmann; L Willems
Journal:  J Virol       Date:  1996-04       Impact factor: 5.103

9.  In vivo protein binding and functional analysis of cis-acting elements in the U3 region of the bovine leukemia virus long terminal repeat.

Authors:  J Xiao; G C Buehring
Journal:  J Virol       Date:  1998-07       Impact factor: 5.103

10.  In vivo rescue of a silent tax-deficient bovine leukemia virus from a tumor-derived ovine B-cell line by recombination with a retrovirally transduced wild-type tax gene.

Authors:  A Van Den Broeke; C Bagnis; M Ciesiolka; Y Cleuter; H Gelderblom; P Kerkhofs; P Griebel; P Mannoni; A Burny
Journal:  J Virol       Date:  1999-02       Impact factor: 5.103
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