Literature DB >> 8057296

Structure-based design of HIV-1 protease inhibitors: replacement of two amides and a 10 pi-aromatic system by a fused bis-tetrahydrofuran.

A K Ghosh1, W J Thompson, P M Fitzgerald, J C Culberson, M G Axel, S P McKee, J R Huff, P S Anderson.   

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Year:  1994        PMID： 8057296     DOI： 10.1021/jm00042a002

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  9 in total

1.  Asymmetric Aldol Route to Hydroxyethylamine Isostere: Stereoselective Synthesis of the Core Unit of Saquinavir.

Authors:  Arun K Ghosh; Khaja Azhar Hussain; Steve Fidanze
Journal:  J Org Chem       Date:  1997-08-22       Impact factor: 4.354

2.  Convenient synthesis of novel macrocyclic urethanes: alkoxycarbonylation of amines and ring-closing metathesis strategy.

Authors:  Arun K Ghosh; Khaja Azhar Hussain
Journal:  Tetrahedron Lett       Date:  1998-04-02       Impact factor: 2.415

3.  SYNTHESIS AND OPTICAL RESOLUTION OF HIGH AFFINITY P2-LIGANDS FOR HIV-1 PROTEASE INHIBITORS.

Authors:  Arun K Ghosh; Yan Chen
Journal:  Tetrahedron Lett       Date:  2000-06-14       Impact factor: 2.415

4.  Chiral Auxiliary Mediated Conjugate Reduction and Asymmetric Protonation: Synthesis of High Affinity Ligands for HIV Protease Inhibitors.

Authors:  Arun K Ghosh; Wenming Liu
Journal:  J Org Chem       Date:  1995-09-01       Impact factor: 4.354

5.  A preference-based free-energy parameterization of enzyme-inhibitor binding. Applications to HIV-1-protease inhibitor design.

Authors:  A Wallqvist; R L Jernigan; D G Covell
Journal:  Protein Sci       Date:  1995-09       Impact factor: 6.725

6.  Disubstituted Bis-THF Moieties as New P2 Ligands in Nonpeptidal HIV-1 Protease Inhibitors.

Authors:  Konrad Hohlfeld; Cyrille Tomassi; Jörg Kurt Wegner; Bart Kesteleyn; Bruno Linclau
Journal:  ACS Med Chem Lett       Date:  2011-03-31       Impact factor: 4.345

7.  A potent human immunodeficiency virus type 1 protease inhibitor, UIC-94003 (TMC-126), and selection of a novel (A28S) mutation in the protease active site.

Authors:  Kazuhisa Yoshimura; Ryohei Kato; Mark F Kavlick; Aline Nguyen; Victor Maroun; Kenji Maeda; Khaja A Hussain; Arun K Ghosh; Sergei V Gulnik; John W Erickson; Hiroaki Mitsuya
Journal:  J Virol       Date:  2002-02       Impact factor: 5.103

8.  Structural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease inhibitor.

Authors:  Nancy M King; Moses Prabu-Jeyabalan; Ellen A Nalivaika; Piet Wigerinck; Marie-Pierre de Béthune; Celia A Schiffer
Journal:  J Virol       Date:  2004-11       Impact factor: 5.103

9.  Insights towards sulfonamide drug specificity in α-carbonic anhydrases.

Authors:  Mayank Aggarwal; Bhargav Kondeti; Robert McKenna
Journal:  Bioorg Med Chem       Date:  2012-08-28       Impact factor: 3.641
  9 in total

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