Literature DB >> 30344339

Chiral Auxiliary Mediated Conjugate Reduction and Asymmetric Protonation: Synthesis of High Affinity Ligands for HIV Protease Inhibitors.

Arun K Ghosh1, Wenming Liu1.   

Abstract

Year:  1995        PMID： 30344339      PMCID： PMC6192046          DOI： 10.1021/jo00124a042

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


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  7 in total

1.  3'-Tetrahydrofuranylglycine as a Novel, Unnatural Amino Acid Surrogate for Asparagine in the Design of Inhibitors of the HIV Protease.

Authors:  Wayne J Thompson; Arun K Ghosh; M Katharine Holloway; Hee Yoon Lee; Peter M Munson; John E Schwering; Jenny Wai; Paul L Darke; Joan Zugay; Emilio A Emini; William A Schleif; Joel R Huff; Paul S Anderson
Journal:  J Am Chem Soc       Date:  1993-01-01       Impact factor: 15.419

2.  Cyclic sulfolanes as novel and high affinity P2 ligands for HIV-1 protease inhibitors.

Authors:  A K Ghosh; W J Thompson; H Y Lee; S P McKee; P M Munson; T T Duong; P L Darke; J A Zugay; E A Emini; W A Schleif
Journal:  J Med Chem       Date:  1993-04-02       Impact factor: 7.446

3.  Structure-based design of HIV-1 protease inhibitors: replacement of two amides and a 10 pi-aromatic system by a fused bis-tetrahydrofuran.

Authors:  A K Ghosh; W J Thompson; P M Fitzgerald; J C Culberson; M G Axel; S P McKee; J R Huff; P S Anderson
Journal:  J Med Chem       Date:  1994-08-05       Impact factor: 7.446

4.  Rational design of peptide-based HIV proteinase inhibitors.

Authors:  N A Roberts; J A Martin; D Kinchington; A V Broadhurst; J C Craig; I B Duncan; S A Galpin; B K Handa; J Kay; A Kröhn
Journal:  Science       Date:  1990-04-20       Impact factor: 47.728

5.  Potent HIV protease inhibitors: the development of tetrahydrofuranylglycines as novel P2-ligands and pyrazine amides as P3-ligands.

Authors:  A K Ghosh; W J Thompson; M K Holloway; S P McKee; T T Duong; H Y Lee; P M Munson; A M Smith; J M Wai; P L Darke
Journal:  J Med Chem       Date:  1993-08-06       Impact factor: 7.446

6.  3-Tetrahydrofuran and pyran urethanes as high-affinity P2-ligands for HIV-1 protease inhibitors.

Authors:  A K Ghosh; W J Thompson; S P McKee; T T Duong; T A Lyle; J C Chen; P L Darke; J A Zugay; E A Emini; W A Schleif
Journal:  J Med Chem       Date:  1993-01-22       Impact factor: 7.446

7.  CYCLIC SULFONE-3-CARBOXAMIDES AS NOVEL P2-LIGANDS FOR Ro 31-8959 BASED HIV-1 PROTEASE INHIBITORS.

Authors:  Arun K Ghosh; Wayne J Thompson; Peter M Munson; Wenming Liut; Joel R Huff
Journal:  Bioorg Med Chem Lett       Date:  2000-03-29       Impact factor: 2.823
  7 in total
  1 in total

1.  Conformationally Constrained Bis(oxazoline) Derived Chiral Catalyst : A Highly Effective Enantioselective Diels-Alder Reaction.

Authors:  Arun K Ghosh; Packiarajan Mathivanan; John Cappiello
Journal:  Tetrahedron Lett       Date:  1996-05-27       Impact factor: 2.415
  1 in total

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