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Literature DB >> 805424

Variability of three-dimensional structure in immunoglobulins.

Abstract

A comparison of various variable immunoglobulin domains demonstrates that structural variability parallels the observed frequency of amino-acid substitutions. The similarity of the structural frameworks is in good agreement with the evolutionary relationships of the chains as derived from sequence analysis.

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Year: 1975 PMID： 805424 PMCID： PMC432411 DOI： 10.1073/pnas.72.3.819

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

13 in total

1. Letter: Recognition of structural domains in globular proteins.

Authors: M G Rossman; A Liljas
Journal: J Mol Biol Date: 1974-05-05 Impact factor: 5.469

Review 2. The antibody problem.

Authors: G M Edelman; W E Gall
Journal: Annu Rev Biochem Date: 1969 Impact factor: 23.643

3. Variable region sequences of five human immunoglobulin heavy chains of the VH3 subgroup: definitive identification of four heavy chain hypervariable regions.

Authors: J D Capra; J M Kehoe
Journal: Proc Natl Acad Sci U S A Date: 1974-03 Impact factor: 11.205

4. Three-dimensional structure of the Fab' fragment of a human immunoglobulin at 2,8-A resolution.

Authors: R J Poljak; L M Amzel; H P Avey; B L Chen; R P Phizackerley; F Saul
Journal: Proc Natl Acad Sci U S A Date: 1973-12 Impact factor: 11.205

5. Crystal and molecular structure of a dimer composed of the variable portions of the Bence-Jones protein REI.

Authors: O Epp; P Colman; H Fehlhammer; W Bode; M Schiffer; R Huber; W Palm
Journal: Eur J Biochem Date: 1974-06-15

Review 6. The development of crystallographic enzymology.

Authors: D C Phillips
Journal: Biochem Soc Symp Date: 1970

7. Structure of a lambda-type Bence-Jones protein at 3.5-A resolution.

Authors: M Schiffer; R L Girling; K R Ely; A B Edmundson
Journal: Biochemistry Date: 1973-11-06 Impact factor: 3.162

8. Attempts to locate complementarity-determining residues in the variable positions of light and heavy chains.

Authors: E A Kabat; T T Wu
Journal: Ann N Y Acad Sci Date: 1971-12-31 Impact factor: 5.691

9. Variable region sequence of the heavy chain from a phosphorylcholine binding myeloma protein.

Authors: S Rudikoff; M Potter
Journal: Biochemistry Date: 1974-09-10 Impact factor: 3.162

10. The three-dimensional structure of a phosphorylcholine-binding mouse immunoglobulin Fab and the nature of the antigen binding site.

Authors: D M Segal; E A Padlan; G H Cohen; S Rudikoff; M Potter; D R Davies
Journal: Proc Natl Acad Sci U S A Date: 1974-11 Impact factor: 11.205

11 in total

Variability of three-dimensional structure in immunoglobulins.

1. Letter: Recognition of structural domains in globular proteins.

Review 2. The antibody problem.

3. Variable region sequences of five human immunoglobulin heavy chains of the VH3 subgroup: definitive identification of four heavy chain hypervariable regions.

4. Three-dimensional structure of the Fab' fragment of a human immunoglobulin at 2,8-A resolution.

5. Crystal and molecular structure of a dimer composed of the variable portions of the Bence-Jones protein REI.

Review 6. The development of crystallographic enzymology.

7. Structure of a lambda-type Bence-Jones protein at 3.5-A resolution.

8. Attempts to locate complementarity-determining residues in the variable positions of light and heavy chains.

9. Variable region sequence of the heavy chain from a phosphorylcholine binding myeloma protein.

10. The three-dimensional structure of a phosphorylcholine-binding mouse immunoglobulin Fab and the nature of the antigen binding site.

1. Flexibility in crystalline insulins.

2. Antibody modeling using the prediction of immunoglobulin structure (PIGS) web server [corrected].

3. Two types of amino acid substitutions in protein evolution.

4. Amino acid sequence of the precursor region of MOPC-315 mouse immunoglobulin heavy chain.

5. Structural invariants of antigen binding: comparison of immunoglobulin VL-VH and VL-VL domain dimers.

6. Variable region framework differences result in decreased or increased affinity of variant anti-digoxin antibodies.

7. Modulation of antibody affinity by a non-contact residue.

8. Structural implications of sequence variability in immunoglobulins.

9. Three-dimensional structure of an intact human immunoglobulin.

10. Crystallographic studies of bovine beta2-microglobulin.