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Literature DB >> 414225

Amino acid sequence of the precursor region of MOPC-315 mouse immunoglobulin heavy chain.

Abstract

Partially purified mRNA coding for the MOPC-315 heavy immunoglobulin alpha chain was translated in a reticulocyte lysate containing 20 labeled amino acids. Radiolabeled MOPC-315 heavy chain precursor protein, purified by preparative gel electrophoresis and immunoprecipitation, was sequenced by Edman degradation. The labeled phenylthiohydantoin amino acid obtained in each cycle was identified and quantitated by high-pressure liquid chromatography. The precursor sequence of 18 amino acids, Met-Lys-Val-Leu-Ser-Leu-Leu-Tyr-Leu-Leu-Thr-Ala-Ile-Pro-His-Ile-Met-Ser, preceded the sequence corresponding to the NH2 terminus of the mature secreted heavy chain.

Entities: Chemical Gene Species

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Year: 1977 PMID： 414225 PMCID： PMC431859 DOI： 10.1073/pnas.74.12.5692

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

30 in total

1. A possible precursor of immunoglobulin light chains.

Authors: C Milstein; G G Brownlee; T M Harrison; M B Mathews
Journal: Nat New Biol Date: 1972-09-27

2. Purification of 14S messenger RNA of immunoglobulin light chain that codes for a possible light-chain precursor.

Authors: B Mach; C Faust; P Vassalli
Journal: Proc Natl Acad Sci U S A Date: 1973-02 Impact factor: 11.205

3. An efficient mRNA-dependent translation system from reticulocyte lysates.

Authors: H R Pelham; R J Jackson
Journal: Eur J Biochem Date: 1976-08-01

4. De novo synthesis and glycosylation of the MOPC-46B mouse immunoglobulin light chain in cell-free extracts.

Authors: P Tucker; S Pestka
Journal: J Biol Chem Date: 1977-07-10 Impact factor: 5.157

5. Amino acid sequence of the NH2-terminal extra piece segments of the precursors of mouse immunoglobulin lambda1-type and kappa-type light chains.

Authors: Y Burstein; I Schechter
Journal: Proc Natl Acad Sci U S A Date: 1977-02 Impact factor: 11.205

6. Cell-free synthesis of fish preproinsulin, and processing by heterologous mammalian microsomal membranes.

Authors: D Shields; G Blobel
Journal: Proc Natl Acad Sci U S A Date: 1977-05 Impact factor: 11.205

7. Initiation and translation in vitro of mRNA for MOPC 315 immunoglobulin heavy chain and characterization of translation product.

Authors: D L Bedard; R C Huang
Journal: J Biol Chem Date: 1977-04-25 Impact factor: 5.157

8. Glutamine as a precursor to N-terminal pyrrolid-2-one-5-carboxylic acid in mouse immunoglobulin lambda-type light chains. Amino acid-sequence variability at the N-terminal extra piece of lambda-type light-chain precursors.

Authors: Y Burstein; I Schechter
Journal: Biochem J Date: 1977-08-01 Impact factor: 3.857

9. Partial amino acid sequence of rat pre-prolactin.

Authors: R A Maurer; J Gorski; D J McKean
Journal: Biochem J Date: 1977-01-01 Impact factor: 3.857

10. Transfer of proteins across membranes. II. Reconstitution of functional rough microsomes from heterologous components.

Authors: G Blobel; B Dobberstein
Journal: J Cell Biol Date: 1975-12 Impact factor: 10.539

6 in total

Review 1. Roy Cameron lecture. Control of antibody formation: certain uncertainties.

Authors: A R Williamson
Journal: J Clin Pathol Suppl (R Coll Pathol) Date: 1979

Review 2. Compilation of published signal sequences.

Authors: M E Watson
Journal: Nucleic Acids Res Date: 1984-07-11 Impact factor: 16.971

3. Cloning and partial nucleotide sequence of human immunoglobulin mu chain cDNA from B cells and mouse-human hybridomas.

Authors: T W Dolby; J Devuono; C M Croce
Journal: Proc Natl Acad Sci U S A Date: 1980-10 Impact factor: 11.205