Literature DB >> 407580

Structural implications of sequence variability in immunoglobulins.

E A Padlan.   

Abstract

Immunoglobulin sequences were compared by using a technique that takes into account the dissimilarity in physicochemical properties of amino acids. Exterior residues showed greater structural variability than interior residues. High structural variability was found at positions known from crystallographic studies to be involved in hapten binding.

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Year:  1977        PMID： 407580      PMCID： PMC432211          DOI： 10.1073/pnas.74.6.2551

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  19 in total

1.  Relations between chemical structure and biological activity in peptides.

Authors:  P H Sneath
Journal:  J Theor Biol       Date:  1966-11       Impact factor: 2.691

2.  Variable region sequences of five human immunoglobulin heavy chains of the VH3 subgroup: definitive identification of four heavy chain hypervariable regions.

Authors:  J D Capra; J M Kehoe
Journal:  Proc Natl Acad Sci U S A       Date:  1974-03       Impact factor: 11.205

3.  Three-dimensional structure of the Fab' fragment of a human immunoglobulin at 2,8-A resolution.

Authors:  R J Poljak; L M Amzel; H P Avey; B L Chen; R P Phizackerley; F Saul
Journal:  Proc Natl Acad Sci U S A       Date:  1973-12       Impact factor: 11.205

4.  Amino acid difference formula to help explain protein evolution.

Authors:  R Grantham
Journal:  Science       Date:  1974-09-06       Impact factor: 47.728

5.  Binding of 2,4-dinitrophenyl compounds and other small molecules to a crystalline lambda-type Bence-Jones dimer.

Authors:  A B Edmundson; K R Ely; R L Girling; E E Abola; M Schiffer; F A Westholm; M D Fausch; H F Deutsch
Journal:  Biochemistry       Date:  1974-08-27       Impact factor: 3.162

6.  Structural basis for the specificity of phosphorylcholine-binding immunoglobulins.

Authors:  E A Padlan; D R Davies; S Rudikoff; M Potter
Journal:  Immunochemistry       Date:  1976-11

7.  The three dimensional structure of a combining region-ligand complex of immunoglobulin NEW at 3.5-A resolution.

Authors:  L M Amzel; R J Poljak; F Saul; J M Varga; F F Richards
Journal:  Proc Natl Acad Sci U S A       Date:  1974-04       Impact factor: 11.205

8.  Amino-acid sequence of an allotype b4 light chain from a rabbit antibody to streptococcal carbohydrate.

Authors:  K C Chen; T J Kindt; R M Krause
Journal:  Proc Natl Acad Sci U S A       Date:  1974-05       Impact factor: 11.205

9.  The three-dimensional structure of a phosphorylcholine-binding mouse immunoglobulin Fab and the nature of the antigen binding site.

Authors:  D M Segal; E A Padlan; G H Cohen; S Rudikoff; M Potter; D R Davies
Journal:  Proc Natl Acad Sci U S A       Date:  1974-11       Impact factor: 11.205

10.  An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity.

Authors:  T T Wu; E A Kabat
Journal:  J Exp Med       Date:  1970-08-01       Impact factor: 14.307
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  9 in total

1.  Patterns of interallelic divergence at the rabbit b-locus of the immunoglobulin light chain constant region are in agreement with population genetical evidence for overdominant selection.

Authors:  W van der Loo; B Verdoodt
Journal:  Genetics       Date:  1992-12       Impact factor: 4.562

2.  Immunogenic peptides of influenza virus subtype N1 neuraminidase identify a T-cell determinant used in class II major histocompatibility complex-restricted responses to infectious virus.

Authors:  C J Hackett; D Horowitz; M Wysocka; L C Eisenlohr
Journal:  J Virol       Date:  1991-02       Impact factor: 5.103

3.  Interaction between the antigen and antibody is controlled by the constant domains: normal mode dynamics of the HEL-HyHEL-10 complex.

Authors:  Masaaki Adachi; Youji Kurihara; Hiroyuki Nojima; Mayuko Takeda-Shitaka; Kenshu Kamiya; Hideaki Umeyama
Journal:  Protein Sci       Date:  2003-10       Impact factor: 6.725

4.  Antibodies designed as effective cancer vaccines.

Authors:  R L Metheringham; V A Pudney; B Gunn; M Towey; I Spendlove; L G Durrant
Journal:  MAbs       Date:  2009 Jan-Feb       Impact factor: 5.857

5.  A mimotope from a solid-phase peptide library induces a measles virus-neutralizing and protective antibody response.

Authors:  M W Steward; C M Stanley; O E Obeid
Journal:  J Virol       Date:  1995-12       Impact factor: 5.103

6.  Modelling of the combining sites of three anti-lysozyme monoclonal antibodies and of the complex between one of the antibodies and its epitope.

Authors:  P de la Paz; B J Sutton; M J Darsley; A R Rees
Journal:  EMBO J       Date:  1986-02       Impact factor: 11.598

7.  Paratome: an online tool for systematic identification of antigen-binding regions in antibodies based on sequence or structure.

Authors:  Vered Kunik; Shaul Ashkenazi; Yanay Ofran
Journal:  Nucleic Acids Res       Date:  2012-06-06       Impact factor: 16.971

8.  H-2Dd exploits a four residue peptide binding motif.

Authors:  M Corr; L F Boyd; E A Padlan; D H Margulies
Journal:  J Exp Med       Date:  1993-12-01       Impact factor: 14.307

Review 9.  Engineered hapten-binding antibody derivatives for modulation of pharmacokinetic properties of small molecules and targeted payload delivery.

Authors:  Stefan Dengl; Claudio Sustmann; Ulrich Brinkmann
Journal:  Immunol Rev       Date:  2016-03       Impact factor: 12.988
  9 in total

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