Literature DB >> 8052638

Promotion of parallel DNA quadruplexes by a yeast telomere binding protein: a circular dichroism study.

R Giraldo1, M Suzuki, L Chapman, D Rhodes.   

Abstract

Repressor-activator protein 1 (RAP1) has an essential role in the maintenance of yeast telomeres. Yeast telomeric DNA consists of simple repeated G-rich sequences that are bound by RAP1. We have found that RAP1, in addition to its known binding activity for double-stranded DNA, interacts with the G-rich strand containing guanine base (G)-tetrads. We show here using circular dichroism spectroscopy that RAP1 promotes the formation of one particular type of DNA quadruplex, parallel G4-DNA. Furthermore, RAP1 is able to bind to both preformed parallel and antiparallel DNA quadruplexes. These results have implications for the possible use of DNA quadruplexes in telomere-telomere association in vivo.

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Year:  1994        PMID： 8052638      PMCID： PMC44461          DOI： 10.1073/pnas.91.16.7658

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  25 in total

1.  Quadruplex structure of d(G3T4G3) stabilized by K+ or Na+ is an asymmetric hairpin dimer.

Authors:  P V Scaria; S J Shire; R H Shafer
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-01       Impact factor: 11.205

2.  Monovalent cation-induced structure of telomeric DNA: the G-quartet model.

Authors:  J R Williamson; M K Raghuraman; T R Cech
Journal:  Cell       Date:  1989-12-01       Impact factor: 41.582

3.  Purification and cloning of a DNA binding protein from yeast that binds to both silencer and activator elements.

Authors:  D Shore; K Nasmyth
Journal:  Cell       Date:  1987-12-04       Impact factor: 41.582

4.  Parallel and antiparallel G-DNA structures from a complex telomeric sequence.

Authors:  E A Venczel; D Sen
Journal:  Biochemistry       Date:  1993-06-22       Impact factor: 3.162

5.  The beta subunit of Oxytricha telomere-binding protein promotes G-quartet formation by telomeric DNA.

Authors:  G Fang; T R Cech
Journal:  Cell       Date:  1993-09-10       Impact factor: 41.582

6.  A protein from Tetrahymena thermophila that specifically binds parallel-stranded G4-DNA.

Authors:  T Schierer; E Henderson
Journal:  Biochemistry       Date:  1994-03-01       Impact factor: 3.162

7.  Characterization of a G-quartet formation reaction promoted by the beta-subunit of the Oxytricha telomere-binding protein.

Authors:  G Fang; T R Cech
Journal:  Biochemistry       Date:  1993-11-02       Impact factor: 3.162

8.  Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase.

Authors:  R J Wellinger; A J Wolf; V A Zakian
Journal:  Cell       Date:  1993-01-15       Impact factor: 41.582

9.  Distortion of the DNA double helix by RAP1 at silencers and multiple telomeric binding sites.

Authors:  E Gilson; M Roberge; R Giraldo; D Rhodes; S M Gasser
Journal:  J Mol Biol       Date:  1993-05-20       Impact factor: 5.469

10.  The yeast telomere-binding protein RAP1 binds to and promotes the formation of DNA quadruplexes in telomeric DNA.

Authors:  R Giraldo; D Rhodes
Journal:  EMBO J       Date:  1994-05-15       Impact factor: 11.598
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  52 in total

1.  Identification of two human nuclear proteins that recognise the cytosine-rich strand of human telomeres in vitro.

Authors:  L Lacroix; H Liénard; E Labourier; M Djavaheri-Mergny; J Lacoste; H Leffers; J Tazi; C Hélène; J L Mergny
Journal:  Nucleic Acids Res       Date:  2000-04-01       Impact factor: 16.971

2.  Resolution of quadruplex polymorphism by size-exclusion chromatography.

Authors:  M Clarke Miller; John O Trent
Journal:  Curr Protoc Nucleic Acid Chem       Date:  2011-06

3.  A single telomerase RNA is sufficient for the synthesis of variable telomeric DNA repeats in ciliates of the genus Paramecium.

Authors:  M McCormick-Graham; D P Romero
Journal:  Mol Cell Biol       Date:  1996-04       Impact factor: 4.272

4.  In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei.

Authors:  C Schaffitzel; I Berger; J Postberg; J Hanes; H J Lipps; A Plückthun
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-03       Impact factor: 11.205

5.  Extension of G-quadruplex DNA by ciliate telomerase.

Authors:  Liana Oganesian; Ian K Moon; Tracy M Bryan; Michael B Jarstfer
Journal:  EMBO J       Date:  2006-03-02       Impact factor: 11.598

Review 6.  In vivo veritas: using yeast to probe the biological functions of G-quadruplexes.

Authors:  Jay E Johnson; Jasmine S Smith; Marina L Kozak; F Brad Johnson
Journal:  Biochimie       Date:  2008-02-21       Impact factor: 4.079

7.  The 3D structures of G-quadruplexes of HIV-1 integrase inhibitors: molecular dynamics simulations in aqueous solution and in the gas phase.

Authors:  Ming-Hui Li; Yi-Han Zhou; Quan Luo; Ze-Sheng Li
Journal:  J Mol Model       Date:  2009-10-04       Impact factor: 1.810

8.  Fluorescent dyes specific for quadruplex DNA.

Authors:  H Arthanari; S Basu; T L Kawano; P H Bolton
Journal:  Nucleic Acids Res       Date:  1998-08-15       Impact factor: 16.971

9.  Divalent transition metal cations counteract potassium-induced quadruplex assembly of oligo(dG) sequences.

Authors:  S W Blume; V Guarcello; W Zacharias; D M Miller
Journal:  Nucleic Acids Res       Date:  1997-02-01       Impact factor: 16.971

10.  Stabilization of G-quadruplex in the BCL2 promoter region in double-stranded DNA by invading short PNAs.

Authors:  Mykola I Onyshchenko; Timur I Gaynutdinov; Ethan A Englund; Daniel H Appella; Ronald D Neumann; Igor G Panyutin
Journal:  Nucleic Acids Res       Date:  2009-12       Impact factor: 16.971
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