Literature DB >> 8045567

Genetic fine localization of the arrestin (S-antigen) gene 4 cM distal from D2S172.

D Valverde1, M Bayés, I Martínez, D Grinberg, L Vilageliu, S Balcells, R Gonzàlez-Duarte, M Baiget.   

Abstract

Arrestin is a component of the light transduction cascade that takes place in the outer segment of retinal rods. In situ hybridization and linkage analysis have localized the arrestin gene to a region of 50 cM between CRYG alpha and D2S23/D2S55 on chromosome 2q24-37. We have performed pairwise and multipoint linkage analysis between arrestin and four highly polymorphic markers from this region. The results indicate tight linkage between the gene and the microsatellite D2S172 (Zmax = 9.25 at theta = 0.038). This fine localization of the gene should provide a useful tool for cosegregation analyses involving the arrestin gene.

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Year:  1994        PMID： 8045567     DOI： 10.1007/bf00202869

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  9 in total

1.  A second-generation linkage map of the human genome.

Authors:  J Weissenbach; G Gyapay; C Dib; A Vignal; J Morissette; P Millasseau; G Vaysseix; M Lathrop
Journal:  Nature       Date:  1992-10-29       Impact factor: 49.962

2.  Detection of multiallele polymorphisms within gene sequences by GC-clamped denaturing gradient gel electrophoresis.

Authors:  V C Sheffield; J S Beck; B Nichols; A Cousineau; A C Lidral; E M Stone
Journal:  Am J Hum Genet       Date:  1992-03       Impact factor: 11.025

3.  The CEPH consortium linkage map of human chromosome 2.

Authors:  N K Spurr; S Cox; S P Bryant; J Attwood; E B Robson; D C Shields; T Steinbrueck; T Jenkins; J C Murray; K K Kidd
Journal:  Genomics       Date:  1992-12       Impact factor: 5.736

4.  Human genetics. Deficiencies in sight with the candidate gene approach.

Authors:  T P Dryja
Journal:  Nature       Date:  1990-10-18       Impact factor: 49.962

5.  A simple salting out procedure for extracting DNA from human nucleated cells.

Authors:  S A Miller; D D Dykes; H F Polesky
Journal:  Nucleic Acids Res       Date:  1988-02-11       Impact factor: 16.971

6.  Visual arrestin interaction with rhodopsin. Sequential multisite binding ensures strict selectivity toward light-activated phosphorylated rhodopsin.

Authors:  V V Gurevich; J L Benovic
Journal:  J Biol Chem       Date:  1993-06-05       Impact factor: 5.157

7.  Dinucleotide repeat loci contribute highly informative genetic markers to the human chromosome 2 linkage map.

Authors:  S Todd; S L Sherman; S L Naylor
Journal:  Genomics       Date:  1993-06       Impact factor: 5.736

8.  Assignment of the S-antigen gene (SAG) to human chromosome 2q24-q37.

Authors:  J T Ngo; I Klisak; R S Sparkes; T Mohandas; K Yamaki; T Shinohara; J B Bateman
Journal:  Genomics       Date:  1990-05       Impact factor: 5.736

9.  Strategies for multilocus linkage analysis in humans.

Authors:  G M Lathrop; J M Lalouel; C Julier; J Ott
Journal:  Proc Natl Acad Sci U S A       Date:  1984-06       Impact factor: 11.205
  9 in total
  2 in total

1.  Oguchi disease: suggestion of linkage to markers on chromosome 2q.

Authors:  M A Maw; S John; S Jablonka; B Müller; G Kumaramanickavel; R Oehlmann; M J Denton; A Gal
Journal:  J Med Genet       Date:  1995-05       Impact factor: 6.318

2.  A new autosomal recessive retinitis pigmentosa locus maps on chromosome 2q31-q33.

Authors:  M Bayés; B Goldaracena; A Martínez-Mir; M I Iragui-Madoz; T Solans; P Chivelet; E Bussaglia; M A Ramos-Arroyo; M Baiget; L Vilageliu; S Balcells; R Gonzàlez-Duarte; D Grinberg
Journal:  J Med Genet       Date:  1998-02       Impact factor: 6.318
  2 in total

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