Literature DB >> 8039513

Telomerase activity in germline and embryonic cells of Xenopus.

L L Mantell1, C W Greider.   

Abstract

Telomerase is a ribonucleoprotein which synthesizes telomere repeats onto chromosome ends. Telomerase activity is involved in telomere length maintenance. We used Xenopus laevis as a model system to study the expression of telomerase activity in germline cells and during early development. We identified a non-processive telomerase activity in manually dissected nuclei of Xenopus stage VI oocytes. Telomerase activity was detected throughout oogenesis and embryogenesis. Telomerase was active in both S and M phase cell cycle extracts, suggesting that telomerase activity is not regulated with chromosomal DNA replication.

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Year:  1994        PMID： 8039513      PMCID： PMC395213          DOI： 10.1002/j.1460-2075.1994.tb06620.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  39 in total

1.  Characterization of synthetic peptide substrates for p34cdc2 protein kinase.

Authors:  D R Marshak; M T Vandenberg; Y S Bae; I J Yu
Journal:  J Cell Biochem       Date:  1991-04       Impact factor: 4.429

2.  In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs.

Authors:  G L Yu; J D Bradley; L D Attardi; E H Blackburn
Journal:  Nature       Date:  1990-03-08       Impact factor: 49.962

Review 3.  Systems for the study of nuclear assembly, DNA replication, and nuclear breakdown in Xenopus laevis egg extracts.

Authors:  C Smythe; J W Newport
Journal:  Methods Cell Biol       Date:  1991       Impact factor: 1.441

4.  Biochemical fractionation of oocytes.

Authors:  J P Evans; B K Kay
Journal:  Methods Cell Biol       Date:  1991       Impact factor: 1.441

Review 5.  Telomere loss: mitotic clock or genetic time bomb?

Authors:  C B Harley
Journal:  Mutat Res       Date:  1991 Mar-Nov       Impact factor: 2.433

Review 6.  Structure and function of telomeres.

Authors:  E H Blackburn
Journal:  Nature       Date:  1991-04-18       Impact factor: 49.962

7.  Oogenesis and oocyte isolation.

Authors:  L D Smith; W L Xu; R L Varnold
Journal:  Methods Cell Biol       Date:  1991       Impact factor: 1.441

8.  Telomere reduction in human colorectal carcinoma and with ageing.

Authors:  N D Hastie; M Dempster; M G Dunlop; A M Thompson; D K Green; R C Allshire
Journal:  Nature       Date:  1990-08-30       Impact factor: 49.962

9.  Functional evidence for an RNA template in telomerase.

Authors:  D Shippen-Lentz; E H Blackburn
Journal:  Science       Date:  1990-02-02       Impact factor: 47.728

10.  Telomeres shorten during ageing of human fibroblasts.

Authors:  C B Harley; A B Futcher; C W Greider
Journal:  Nature       Date:  1990-05-31       Impact factor: 49.962
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  43 in total

1.  Kinetochore reproduction in animal evolution: cell biological explanation of karyotypic fission theory.

Authors:  R L Kolnicki
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-15       Impact factor: 11.205

2.  Characterization of the interaction between the nuclease and reverse transcriptase activity of the yeast telomerase complex.

Authors:  H Niu; J Xia; N F Lue
Journal:  Mol Cell Biol       Date:  2000-09       Impact factor: 4.272

3.  An ES-like cell line from the marine fish Sparus aurata: characterization and chimaera production.

Authors:  Julia Béjar; Yunhan Hong; M Carmen Alvarez
Journal:  Transgenic Res       Date:  2002-06       Impact factor: 2.788

4.  Cell-cycle-dependent Xenopus TRF1 recruitment to telomere chromatin regulated by Polo-like kinase.

Authors:  Atsuya Nishiyama; Keiko Muraki; Motoki Saito; Keita Ohsumi; Takeo Kishimoto; Fuyuki Ishikawa
Journal:  EMBO J       Date:  2006-01-19       Impact factor: 11.598

Review 5.  Fish ES cells and applications to biotechnology.

Authors:  M Carmen Alvarez; Julia Béjar; Songlin Chen; Yunhan Hong
Journal:  Mar Biotechnol (NY)       Date:  2006-11-06       Impact factor: 3.619

6.  A single telomerase RNA is sufficient for the synthesis of variable telomeric DNA repeats in ciliates of the genus Paramecium.

Authors:  M McCormick-Graham; D P Romero
Journal:  Mol Cell Biol       Date:  1996-04       Impact factor: 4.272

7.  Oligonucleotides complementary to the Oxytricha nova telomerase RNA delineate the template domain and uncover a novel mode of primer utilization.

Authors:  M Melek; B T Davis; D E Shippen
Journal:  Mol Cell Biol       Date:  1994-12       Impact factor: 4.272

8.  Identification of Kluyveromyces lactis telomerase: discontinuous synthesis along the 30-nucleotide-long templating domain.

Authors:  T B Fulton; E H Blackburn
Journal:  Mol Cell Biol       Date:  1998-09       Impact factor: 4.272

9.  Barley telomeres shorten during differentiation but grow in callus culture.

Authors:  A Kilian; C Stiff; A Kleinhofs
Journal:  Proc Natl Acad Sci U S A       Date:  1995-10-10       Impact factor: 11.205

10.  A homozygous telomerase T-motif variant resulting in markedly reduced repeat addition processivity in siblings with Hoyeraal Hreidarsson syndrome.

Authors:  Maria M Gramatges; Xiaodong Qi; Ghadir S Sasa; Julian J-L Chen; Alison A Bertuch
Journal:  Blood       Date:  2013-03-28       Impact factor: 22.113
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