| Literature DB >> 1689810 |
G L Yu1, J D Bradley, L D Attardi, E H Blackburn.
Abstract
Mutating the CAACCCCAA sequence in the RNA component of telomerase causes the synthesis in vivo of new telomere sequences corresponding to the mutated RNA sequence, demonstrating that the telomerase contains the template for telomere synthesis. These mutations also lead to nuclear and cell division defects, and senescence, establishing an essential role for telomerase in vivo.Mesh：
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Year: 1990 PMID： 1689810 DOI： 10.1038/344126a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962