Literature DB >> 8031059

Mutations in the tetA(B) gene that cause a change in substrate specificity of the tetracycline efflux pump.

G G Guay1, M Tuckman, D M Rothstein.   

Abstract

The tetA(B) gene from transposon Tn10 fails to mediate resistance to the novel tetracycline analog 9-(dimethylglycylamido)minocycline (DMG-Mino) (P. E. Sum, V. J. Lee, R. T. Testa, J. J. Hlavka, G. A. Ellestad, J. D. Bloom, Y. Gluzman, and F. P. Tally, J. Med. Chem. 37:184-188, 1994; R. T. Testa, P. Petersen, N. V. Jacobus, P. E. Sum, V. J. Lee, and F. P. Tally, Antimicrob. Agents Chemother. 37:2270-2277, 1993). Mutations in either of two codons of tetA(B) that resulted in increased resistance to DMG-Mino also caused diminished resistance to tetracycline, identifying amino acid residues critical for the recognition of tetracycline.

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Year:  1994        PMID： 8031059      PMCID： PMC284555          DOI： 10.1128/AAC.38.4.857

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  27 in total

Review 1.  Tetracyclines, molecular and clinical aspects.

Authors:  I Chopra; P M Hawkey; M Hinton
Journal:  J Antimicrob Chemother       Date:  1992-03       Impact factor: 5.790

2.  Stoichiometry of metal-tetracycline/H+ antiport mediated by transposon Tn10-encoded tetracycline resistance protein in Escherichia coli.

Authors:  A Yamaguchi; Y Iwasaki-Ohba; N Ono; M Kaneko-Ohdera; T Sawai
Journal:  FEBS Lett       Date:  1991-05-06       Impact factor: 4.124

3.  Sequence of a class E tetracycline resistance gene from Escherichia coli and comparison of related tetracycline efflux proteins.

Authors:  J D Allard; K P Bertrand
Journal:  J Bacteriol       Date:  1993-07       Impact factor: 3.490

4.  Metal-tetracycline/H+ antiporter of Escherichia coli encoded by a transposon Tn10. Histidine 257 plays an essential role in H+ translocation.

Authors:  A Yamaguchi; K Adachi; T Akasaka; N Ono; T Sawai
Journal:  J Biol Chem       Date:  1991-04-05       Impact factor: 5.157

5.  Expression of the tetK gene from Staphylococcus aureus in Escherichia coli: comparison of substrate specificities of TetA(B), TetA(C), and TetK efflux proteins.

Authors:  G G Guay; D M Rothstein
Journal:  Antimicrob Agents Chemother       Date:  1993-02       Impact factor: 5.191

6.  Aspartic acid-66 is the only essential negatively charged residue in the putative hydrophilic loop region of the metal-tetracycline/H+ antiporter encoded by transposon Tn10 of Escherichia coli.

Authors:  A Yamaguchi; M Nakatani; T Sawai
Journal:  Biochemistry       Date:  1992-09-08       Impact factor: 3.162

7.  Metal-tetracycline/H+ antiporter of Escherichia coli encoded by transposon Tn10. The role of a conserved sequence motif, GXXXXRXGRR, in a putative cytoplasmic loop between helices 2 and 3.

Authors:  A Yamaguchi; Y Someya; T Sawai
Journal:  J Biol Chem       Date:  1992-09-25       Impact factor: 5.157

8.  Genetic analysis of the tetA(C) gene on plasmid pBR322.

Authors:  P McNicholas; I Chopra; D M Rothstein
Journal:  J Bacteriol       Date:  1992-12       Impact factor: 3.490

Review 9.  Bacterial resistance to tetracycline: mechanisms, transfer, and clinical significance.

Authors:  B S Speer; N B Shoemaker; A A Salyers
Journal:  Clin Microbiol Rev       Date:  1992-10       Impact factor: 26.132

10.  Metal-tetracycline/H+ antiporter of Escherichia coli encoded by transposon Tn10. Roles of the aspartyl residues located in the putative transmembrane helices.

Authors:  A Yamaguchi; T Akasaka; N Ono; Y Someya; M Nakatani; T Sawai
Journal:  J Biol Chem       Date:  1992-04-15       Impact factor: 5.157
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  8 in total

Review 1.  Tetracycline Antibiotics and Resistance.

Authors:  Trudy H Grossman
Journal:  Cold Spring Harb Perspect Med       Date:  2016-04-01       Impact factor: 6.915

2.  Combined ramR mutation and presence of a Tn1721-associated tet(A) variant in a clinical isolate of Salmonella enterica serovar Hadar resistant to tigecycline.

Authors:  M Hentschke; M Christner; I Sobottka; M Aepfelbacher; H Rohde
Journal:  Antimicrob Agents Chemother       Date:  2009-12-22       Impact factor: 5.191

3.  Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance.

Authors:  I Chopra; M Roberts
Journal:  Microbiol Mol Biol Rev       Date:  2001-06       Impact factor: 11.056

4.  Transcriptomic Responses and Survival Mechanisms of Staphylococci to the Antimicrobial Skin Lipid Sphingosine.

Authors:  Yiyun Chen; Josephine C Moran; Stuart Campbell-Lee; Malcolm J Horsburgh
Journal:  Antimicrob Agents Chemother       Date:  2021-12-13       Impact factor: 5.938

5.  A novel glycylcycline, 9-(N,N-dimethylglycylamido)-6-demethyl-6-deoxytetracycline, is neither transported nor recognized by the transposon Tn10-encoded metal-tetracycline/H+ antiporter.

Authors:  Y Someya; A Yamaguchi; T Sawai
Journal:  Antimicrob Agents Chemother       Date:  1995-01       Impact factor: 5.191

6.  Fe(2+)-tetracycline-mediated cleavage of the Tn10 tetracycline efflux protein TetA reveals a substrate binding site near glutamine 225 in transmembrane helix 7.

Authors:  Laura M McMurry; Mila L Aldema-Ramos; Stuart B Levy
Journal:  J Bacteriol       Date:  2002-09       Impact factor: 3.490

7.  Detection and expression analysis of tet(B) in Streptococcus oralis.

Authors:  Alexandre Arredondo; Gerard Àlvarez; José Nart; Carolina Mor; Vanessa Blanc; Rubén León
Journal:  J Oral Microbiol       Date:  2019-07-23       Impact factor: 5.474

8.  Potential of Tetracycline Resistance Proteins To Evolve Tigecycline Resistance.

Authors:  Marius Linkevicius; Linus Sandegren; Dan I Andersson
Journal:  Antimicrob Agents Chemother       Date:  2015-11-23       Impact factor: 5.191
  8 in total

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