Literature DB >> 20028818

Combined ramR mutation and presence of a Tn1721-associated tet(A) variant in a clinical isolate of Salmonella enterica serovar Hadar resistant to tigecycline.

M Hentschke1, M Christner, I Sobottka, M Aepfelbacher, H Rohde.   

Abstract

A Salmonella enterica serovar Hadar strain resistant to tigecycline (MIC, 16 microg/ml) was isolated. Molecular characterization revealed the presence of a plasmid-borne tet(A) variant associated with Tn1721 mediating a rise of the MIC for tigecycline when transferred to Escherichia coli. Additionally, a truncating mutation in ramR was detected. Transformation with wild-type ramR but not with the mutated ramR lowered the MIC for tigecycline. Characterization of this Salmonella isolate implicates ramR in resistance to tigecycline.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 20028818      PMCID： PMC2826014          DOI： 10.1128/AAC.00993-09

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  29 in total

1.  Development, validation, and application of PCR primers for detection of tetracycline efflux genes of gram-negative bacteria.

Authors:  R I Aminov; J C Chee-Sanford; N Garrigues; B Teferedegne; I J Krapac; B A White; R I Mackie
Journal:  Appl Environ Microbiol       Date:  2002-04       Impact factor: 4.792

2.  Mutations in the interdomain loop region of the tetA(A) tetracycline resistance gene increase efflux of minocycline and glycylcyclines.

Authors:  M Tuckman; P J Petersen; S J Projan
Journal:  Microb Drug Resist       Date:  2000       Impact factor: 3.431

3.  Presence of tetracycline resistance determinants and susceptibility to tigecycline and minocycline.

Authors:  Ad C Fluit; Alice Florijn; Jan Verhoef; Dana Milatovic
Journal:  Antimicrob Agents Chemother       Date:  2005-04       Impact factor: 5.191

4.  Influence of transcriptional activator RamA on expression of multidrug efflux pump AcrAB and tigecycline susceptibility in Klebsiella pneumoniae.

Authors:  Alexey Ruzin; Melissa A Visalli; David Keeney; Patricia A Bradford
Journal:  Antimicrob Agents Chemother       Date:  2005-03       Impact factor: 5.191

5.  In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t-butylglycylamido derivative of minocycline (GAR-936).

Authors:  P J Petersen; N V Jacobus; W J Weiss; P E Sum; R T Testa
Journal:  Antimicrob Agents Chemother       Date:  1999-04       Impact factor: 5.191

6.  AcrAB efflux pump plays a role in decreased susceptibility to tigecycline in Morganella morganii.

Authors:  Alexey Ruzin; David Keeney; Patricia A Bradford
Journal:  Antimicrob Agents Chemother       Date:  2005-02       Impact factor: 5.191

7.  Efflux-mediated resistance to tigecycline (GAR-936) in Pseudomonas aeruginosa PAO1.

Authors:  Charles R Dean; Melissa A Visalli; Steven J Projan; Phaik-Eng Sum; Patricia A Bradford
Journal:  Antimicrob Agents Chemother       Date:  2003-03       Impact factor: 5.191

8.  Mutations in the tetA(B) gene that cause a change in substrate specificity of the tetracycline efflux pump.

Authors:  G G Guay; M Tuckman; D M Rothstein
Journal:  Antimicrob Agents Chemother       Date:  1994-04       Impact factor: 5.191

9.  AcrAB multidrug efflux pump is associated with reduced levels of susceptibility to tigecycline (GAR-936) in Proteus mirabilis.

Authors:  Melissa A Visalli; Ellen Murphy; Steven J Projan; Patricia A Bradford
Journal:  Antimicrob Agents Chemother       Date:  2003-02       Impact factor: 5.191

10.  Effects of efflux transporter genes on susceptibility of Escherichia coli to tigecycline (GAR-936).

Authors:  Takahiro Hirata; Asami Saito; Kunihiko Nishino; Norihisa Tamura; Akihito Yamaguchi
Journal:  Antimicrob Agents Chemother       Date:  2004-06       Impact factor: 5.191
View more
  17 in total

1.  ramR mutations in clinical isolates of Klebsiella pneumoniae with reduced susceptibility to tigecycline.

Authors:  M Hentschke; M Wolters; I Sobottka; H Rohde; M Aepfelbacher
Journal:  Antimicrob Agents Chemother       Date:  2010-03-29       Impact factor: 5.191

2.  Susceptibility of tetracyclines to Tet(a) resistance is independent of interdomain loop sequence.

Authors:  Corey Fyfe; Joyce A Sutcliffe; Trudy H Grossman
Journal:  Antimicrob Agents Chemother       Date:  2013-03-11       Impact factor: 5.191

3.  Mechanisms of tigecycline resistance among Klebsiella pneumoniae clinical isolates.

Authors:  Zi-Ke Sheng; Fupin Hu; Weixia Wang; Qinglan Guo; Zhijun Chen; Xiaogang Xu; Demei Zhu; Minggui Wang
Journal:  Antimicrob Agents Chemother       Date:  2014-09-02       Impact factor: 5.191

4.  Roles of ramR and tet(A) Mutations in Conferring Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.

Authors:  Sheng-Kang Chiu; Li-Yueh Huang; Hsi Chen; Yu-Kuo Tsai; Ci-Hong Liou; Jung-Chung Lin; L Kristopher Siu; Feng-Yee Chang; Kuo-Ming Yeh
Journal:  Antimicrob Agents Chemother       Date:  2017-07-25       Impact factor: 5.191

5.  Target- and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibiotic.

Authors:  Trudy H Grossman; Agata L Starosta; Corey Fyfe; William O'Brien; David M Rothstein; Aleksandra Mikolajka; Daniel N Wilson; Joyce A Sutcliffe
Journal:  Antimicrob Agents Chemother       Date:  2012-02-21       Impact factor: 5.191

6.  Studies on the Transmission of a Tigecycline Resistance-Mediating tet(A) Gene Variant from Enterobacter hormaechei via a Two-Step Recombination Process.

Authors:  Runhao Yu; Zheng Chen; Danyang Li; Stefan Schwarz; Xinwei Wang; Xiang-Dang Du
Journal:  Microbiol Spectr       Date:  2022-05-17

7.  Resistance in In Vitro Selected Tigecycline-Resistant Methicillin-Resistant Staphylococcus aureus Sequence Type 5 Is Driven by Mutations in mepR and mepA Genes.

Authors:  Andrei Nicoli Gebieluca Dabul; Juliana Sposto Avaca-Crusca; Daria Van Tyne; Michael S Gilmore; Ilana Lopes Baratella Cunha Camargo
Journal:  Microb Drug Resist       Date:  2017-10-17       Impact factor: 3.431

8.  Tigecycline challenge triggers sRNA production in Salmonella enterica serovar Typhimurium.

Authors:  Jing Yu; Thamarai Schneiders
Journal:  BMC Microbiol       Date:  2012-09-07       Impact factor: 3.605

9.  ramR mutations affecting fluoroquinolone susceptibility in epidemic multidrug-resistant Salmonella enterica serovar Kentucky ST198.

Authors:  Sylvie Baucheron; Simon Le Hello; Benoît Doublet; Etienne Giraud; François-Xavier Weill; Axel Cloeckaert
Journal:  Front Microbiol       Date:  2013-07-31       Impact factor: 5.640

10.  Lack of efflux mediated quinolone resistance in Salmonella enterica serovars Typhi and Paratyphi A.

Authors:  Sylvie Baucheron; Isabelle Monchaux; Simon Le Hello; François-Xavier Weill; Axel Cloeckaert
Journal:  Front Microbiol       Date:  2014-01-27       Impact factor: 5.640
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.