Literature DB >> 803017

Analysis of family resemblance. IV. Operational characteristics of segregation analysis.

C J MacLean1, N E Morton, R Lew.   

Abstract

In simulated data, segregation analysis of quantitative traits was found to be powerful for resolving a major locus from polygenic and cultural inheritance. It is reasonably robust against a variety of deviations from the model if and only if a major locus, polygenic heritability, and environment common to sibs are simultaneously included in the model, and heterogeneity tests among mating types are performed. Most of the information in quantitative data about a major locus is lost when reduced to affection status.

Mesh：

Year:  1975        PMID： 803017      PMCID： PMC1762886     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  5 in total

1.  Genetic tests under incomplete ascertainment.

Authors:  N E MORTON
Journal:  Am J Hum Genet       Date:  1959-03       Impact factor: 11.025

2.  Analysis of family resemblance. 3. Complex segregation of quantitative traits.

Authors:  N E Morton; C J MacLean
Journal:  Am J Hum Genet       Date:  1974-07       Impact factor: 11.025

3.  Analysis of family resemblance. II. A linear model for familial correlation.

Authors:  D C Rao; N E Morton; S Yee
Journal:  Am J Hum Genet       Date:  1974-05       Impact factor: 11.025

4.  Discriminating between different modes of inheritance in genetic disease.

Authors:  C Smith
Journal:  Clin Genet       Date:  1971       Impact factor: 4.438

5.  The detection of major genes under additive continuous variation.

Authors:  N E Morton
Journal:  Am J Hum Genet       Date:  1967-01       Impact factor: 11.025
  5 in total
  41 in total

Review 1.  Genetics and pulmonary medicine.10: Genetic epidemiology of pulmonary function.

Authors:  Y Chen
Journal:  Thorax       Date:  1999-09       Impact factor: 9.139

2.  Complex segregation analysis of the locus for beta-aminoisobutyric acid excretion (BAIB).

Authors:  S P Simpson; N E Morton
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

3.  A Monte Carlo method for combined segregation and linkage analysis.

Authors:  S W Guo; E A Thompson
Journal:  Am J Hum Genet       Date:  1992-11       Impact factor: 11.025

4.  Computer simulation is an undervalued tool for genetic analysis: a historical view and presentation of SHIMSHON--a Web-based genetic simulation package.

Authors:  David A Greenberg
Journal:  Hum Hered       Date:  2011-12-23       Impact factor: 0.444

5.  The genetic and environmental sources of body mass index variability: the Muscatine Ponderosity Family Study.

Authors:  P P Moll; T L Burns; R M Lauer
Journal:  Am J Hum Genet       Date:  1991-12       Impact factor: 11.025

Review 6.  Genetic markers in atherosclerosis: a review.

Authors:  N E Morton
Journal:  J Med Genet       Date:  1976-04       Impact factor: 6.318

7.  Conclusion of LOD-score analysis for family data generated under two-locus models.

Authors:  M H Dizier; M C Babron; F Clerget-Darpoux
Journal:  Am J Hum Genet       Date:  1996-06       Impact factor: 11.025

8.  Genetic analysis of idiopathic hemochromatosis using both qualitative (disease status) and quantitative (serum iron) information.

Authors:  J M Lalouel; L Le Mignon; M Simon; R Fauchet; M Bourel; D C Rao; N E Morton
Journal:  Am J Hum Genet       Date:  1985-07       Impact factor: 11.025

9.  Major loci for lipoprotein concentrations.

Authors:  N E Morton; C L Gulbrandsen; G G Rhoads; A Kagan; R Lew
Journal:  Am J Hum Genet       Date:  1978-11       Impact factor: 11.025

10.  Genetic polymorphism for human platelet thermostable phenol sulfotransferase (TS PST) activity.

Authors:  R A Price; R S Spielman; A L Lucena; J A Van Loon; B L Maidak; R M Weinshilboum
Journal:  Genetics       Date:  1989-08       Impact factor: 4.562
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