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Literature DB >> 79996

Inhibition of oncornavirus functions by poly (2-methylthioinosinic acid).

E De Clercq, A Billiau, M Hattori, M Ikehara.

Abstract

Poly (2-methylthioinosinic acid) [poly(ms2I)] was found to markedly inhibit the RNA directed DNA polymerase (reverse transcriptase) activity of murine (Moloney, Rauscher) leukemia virus and murine (Moloney) sarcoma virus, while under the same conditions the unsubstituted parent compound poly(I) showed little, if any, inhibitory effect. Copolymers of inosinic acid (I) and 2-methylthioinosinic acid2(ms2I) showed an intermediary effect, depending on the I:ms2I ratio. Poly(ms2I) also inhibited the transformation of normal cells by murine (Moloney) sarcoma virus, as assessed by an infectious center assay.

Entities: Chemical Disease Species

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Year: 1975 PMID： 79996 PMCID： PMC343598 DOI： 10.1093/nar/2.12.2305

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

29 in total

1. Antiviral activity of partially thiolated polynucleotides.

Authors: J A O'Malley; Y K Ho; P Chakrabarti; L DiBerardino; P Chandra; D A Orinda; D M Byrd; T J Bardos; W A Carter
Journal: Mol Pharmacol Date: 1975-01 Impact factor: 4.436

2. Inhibition of RNA directed DNA polymerase of murine leukemia virus by 2'-O-alkylated polyadenylic acids.

Authors: S K Arya; W A Carter; J L Alderfer; P O Ts'o
Journal: Biochem Biophys Res Commun Date: 1974-07-24 Impact factor: 3.575

3. Poly(2'-O-methylcytidylate)-oligodeoxyguanylate as a template for the ribonucleic acid directed deoxyribonucleic acid polymerase in ribonucleic acid tumor virus particles and a specific probe for the ribonucleic acid directed enzyme in transformed murine cells.

Authors: G F Gerard; F Rottman; M Green
Journal: Biochemistry Date: 1974-04-09 Impact factor: 3.162

Inhibition of oncornavirus functions by poly (2-methylthioinosinic acid).

1. Antiviral activity of partially thiolated polynucleotides.

2. Inhibition of RNA directed DNA polymerase of murine leukemia virus by 2'-O-alkylated polyadenylic acids.

3. Poly(2'-O-methylcytidylate)-oligodeoxyguanylate as a template for the ribonucleic acid directed deoxyribonucleic acid polymerase in ribonucleic acid tumor virus particles and a specific probe for the ribonucleic acid directed enzyme in transformed murine cells.

4. DNA polymerase activity from two temperature-sensitive mutants of Rous sarcoma virus is thermolabile.

5. A more sensitive assay system for the detection of RNA-dependent DNA polymerase in oncogenic RNA viruses.

6. Effects of polyadenylic acids on functions of murine RNA tumor viruses.

7. DNA polymerases from RNA tumor viruses and human cells: inhibition by polyuridylic acid.

8. Inhibition of murine leukemia virus replication by poly(vinyluracil) and poly(vinyladenine).

9. Primer requirement and template specificity of the DNA polymerase of RNA tumor viruses.

10. Distinguishing reverse transcriptase of an RNA tumor virus from other known DNA polymerases.

1. Interferon induction: a conformational hypothesis.

2. Role of purine N-3 in the biologic activities of poly(A) and poly(I).

3. Poly 2'-O-ethylcytidylate, an inhibitor and poor template for AMV reverse transcriptase.

4. Biologic activities of poly (2-azaadenylic acid) and poly (2-azainosinic acid).