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Literature DB >> 4123932

Inhibition of murine leukemia virus replication by poly(vinyluracil) and poly(vinyladenine).

P M Pitha, N M Teich, D R Lowy, J Pitha.

Abstract

Poly(1-vinyluracil) and poly(9-vinyladenine), as well as the corresponding polynucleotides poly(uridylate) and poly(adenylate), inhibit acute murine leukemia virus infection in mouse-embryo cells, but they do not significantly inhibit the replication of Sindbis and vesicular stomatitis viruses. The polymers were most effective as inhibitors when added during an early stage of virus replication. Effects of vinyl polymers on the RNA-dependent DNA polymerase from the virions of murine leukemia virus were also observed.

Entities: Chemical Disease Species

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Year: 1973 PMID： 4123932 PMCID： PMC433458 DOI： 10.1073/pnas.70.4.1204

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

23 in total

1. Counting actively metabolizing tissue cultured cells.

Authors: H J PHILLIPS; J E TERRYBERRY
Journal: Exp Cell Res Date: 1957-10 Impact factor: 3.905

2. Viral genetic systems.

Authors: D Baltimore
Journal: Trans N Y Acad Sci Date: 1971-03

3. Streptovaricins inhibit RNA dependent DNA polymerase present in an oncogenic RNA virus.

Authors: W W Brockman; W A Carter; L H Li; F Reusser; F R Nichol
Journal: Nature Date: 1971-03-26 Impact factor: 49.962

4. Preparation and properties of poly-9-vinyladenine.

Authors: P M Pitha; J Pitha
Journal: Biopolymers Date: 1970 Impact factor: 2.505

5. Poly(1-vinyluracil): the preparation and interactions with adenosine derivatives.

Authors: J Pitha; P M Pitha; P O Ts'o
Journal: Biochim Biophys Acta Date: 1970-03-19

6. An adenylic acid-rich sequence in messenger RNA of HeLa cells and its possible relationship to reiterated sites in DNA.

Authors: J E Darnell; R Wall; R J Tushinski
Journal: Proc Natl Acad Sci U S A Date: 1971-06 Impact factor: 11.205

7. Selective interference with viral RNA formation in vitro by specific inhibition with synthetic polyribonucleotides.

Authors: I Haruna; S Spiegelman
Journal: Proc Natl Acad Sci U S A Date: 1966-10 Impact factor: 11.205

8. Plaque assay techniques for murine leukemia viruses.

Authors: W P Rowe; W E Pugh; J W Hartley
Journal: Virology Date: 1970-12 Impact factor: 3.616

9. Primer requirement and template specificity of the DNA polymerase of RNA tumor viruses.

Authors: D Baltimore; D Smoler
Journal: Proc Natl Acad Sci U S A Date: 1971-07 Impact factor: 11.205

10. Polyadenylic acid sequences in the heterogeneous nuclear RNA and rapidly-labeled polyribosomal RNA of HeLa cells: possible evidence for a precursor relationship.

Authors: M Edmonds; M H Vaughan; H Nakazato
Journal: Proc Natl Acad Sci U S A Date: 1971-06 Impact factor: 11.205

6 in total

1. Effects of polyadenylic acids on functions of murine RNA tumor viruses.

Authors: R W Tennant; J G Farrelly; J N Ihle; B C Pal; F T Kenney; A Brown
Journal: J Virol Date: 1973-12 Impact factor: 5.103

2. Effects of poly(2'-O-methyladenylic acid) on susceptibility and autogenous immunity to RNA tumor virus oncogenesis in vivo.

Authors: R W Tennant; M G Hanna; J G Farrelly
Journal: Proc Natl Acad Sci U S A Date: 1974-08 Impact factor: 11.205