OBJECTIVES: To determine whether Mycobacterium tuberculosis DNA can be detected in synovial fluid of patients with rheumatoid arthritis (RA). METHODS: The polymerase chain reaction was applied to cellular components of synovial fluid. RESULTS: No evidence of M tuberculosis DNA was found in synovial fluid from 31 patients with RA and 13 control patients. CONCLUSION: The findings do not support a role for persistent M tuberculosis infection in the pathogenesis of RA.
OBJECTIVES: To determine whether Mycobacterium tuberculosis DNA can be detected in synovial fluid of patients with rheumatoid arthritis (RA). METHODS: The polymerase chain reaction was applied to cellular components of synovial fluid. RESULTS: No evidence of M tuberculosis DNA was found in synovial fluid from 31 patients with RA and 13 control patients. CONCLUSION: The findings do not support a role for persistent M tuberculosis infection in the pathogenesis of RA.
Authors: K Granfors; S Jalkanen; A A Lindberg; O Mäki-Ikola; R von Essen; R Lahesmaa-Rantala; H Isomäki; R Saario; W J Arnold; A Toivanen Journal: Lancet Date: 1990-03-24 Impact factor: 79.321
Authors: P C Res; C G Schaar; F C Breedveld; W van Eden; J D van Embden; I R Cohen; R R de Vries Journal: Lancet Date: 1988-08-27 Impact factor: 79.321
Authors: K Granfors; S Jalkanen; R von Essen; R Lahesmaa-Rantala; O Isomäki; K Pekkola-Heino; R Merilahti-Palo; R Saario; H Isomäki; A Toivanen Journal: N Engl J Med Date: 1989-01-26 Impact factor: 91.245
Authors: J Holoshitz; A Klajman; I Drucker; Z Lapidot; A Yaretzky; A Frenkel; W van Eden; I R Cohen Journal: Lancet Date: 1986-08-09 Impact factor: 79.321
Authors: K E Kempsell; C J Cox; A A McColm; J A Bagshaw; R Reece; D J Veale; P Emery; J D Isaacs; J S Gaston; J S Crowe Journal: Infect Immun Date: 2001-03 Impact factor: 3.441