Literature DB >> 6228565

Arthritis induced in rats by cloned T lymphocytes responsive to mycobacteria but not to collagen type II.

J Holoshitz, A Matitiau, I R Cohen.   

Abstract

We have been studying the pathogenesis of adjuvant arthritis in rats using a long-term cell line of T lymphocytes, the A2 line, which can induce polyarthritis and can also be used to vaccinate rats against adjuvant arthritis. Although line A2 was selected for its proliferative response to mycobacteria, it also responded to collagen type II. To elucidate its role of responsiveness to collagen type II and the relationship between arthritogenicity and vaccination, we cloned A2 and selected a subline A2b. We now report that subline A2b, which bore a marker of helper/delayed hypersensitivity T lymphocytes, was strongly arthritogenic, but could not vaccinate against arthritis. Moreover, A2b showed no response to collagen type II. Therefore, reactivity to collagen type II is not a requisite for arthritogenicity, and mediation of arthritis and vaccination can be distinct properties of different populations of T lymphocytes.

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Year:  1984        PMID： 6228565      PMCID： PMC425000          DOI： 10.1172/JCI111193

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  16 in total

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Journal:  J Exp Med       Date:  1964-10-01       Impact factor: 14.307

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Journal:  Cell Immunol       Date:  1972-01       Impact factor: 4.868

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Journal:  N Engl J Med       Date:  1978-08-17       Impact factor: 91.245

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Journal:  Cell Immunol       Date:  1983-02-01       Impact factor: 4.868

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Journal:  J Clin Invest       Date:  1980-11       Impact factor: 14.808

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Journal:  Arthritis Rheum       Date:  1982-11

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Journal:  J Exp Med       Date:  1982-01-01       Impact factor: 14.307

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Authors:  D E Trentham; A S Townes; A H Kang
Journal:  J Exp Med       Date:  1977-09-01       Impact factor: 14.307
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  74 in total

1.  Competition for antigenic sites during T cell proliferation: a mathematical interpretation of in vitro data.

Authors:  J A Borghans; L S Taams; M H Wauben; R J de Boer
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-14       Impact factor: 11.205

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Journal:  Pharm Res       Date:  2000-06       Impact factor: 4.200

3.  HIV-1 fusion peptide targets the TCR and inhibits antigen-specific T cell activation.

Authors:  Francisco J Quintana; Doron Gerber; Sally C Kent; Irun R Cohen; Yechiel Shai
Journal:  J Clin Invest       Date:  2005-07-07       Impact factor: 14.808

Review 4.  Outer membrane protein PhoE as a carrier for the exposure of foreign antigenic determinants at the bacterial cell surface.

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Journal:  Antonie Van Leeuwenhoek       Date:  1991-05       Impact factor: 2.271

Review 5.  Molecular mimicry--hypothesis or reality?

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Journal:  West J Med       Date:  1992-08

Review 6.  Mycobacterium tuberculosis, autoimmunity, and vitamin D.

Authors:  Yinon Shapira; Nancy Agmon-Levin; Yehuda Shoenfeld
Journal:  Clin Rev Allergy Immunol       Date:  2010-04       Impact factor: 8.667

Review 7.  The 65-kDa heat-shock protein in the pathogenesis, prevention and therapy of autoimmune arthritis and diabetes mellitus in rats and mice.

Authors:  U Feige; I R Cohen
Journal:  Springer Semin Immunopathol       Date:  1991

Review 8.  The role of gamma delta T cells in the normal and disordered immune system.

Authors:  B Bröker; P M Lydyard; F Emmrich
Journal:  Klin Wochenschr       Date:  1990-05-17

9.  Salubrious effect of Semecarpus anacardium against lipid peroxidative changes in adjuvant arthritis studied in rats.

Authors:  T Vijayalakshmi; V Muthulakshmi; P Sachdanandam
Journal:  Mol Cell Biochem       Date:  1997-10       Impact factor: 3.396

10.  Immunological characterization of a human homolog of the 65-kilodalton mycobacterial antigen.

Authors:  A K Dudani; R S Gupta
Journal:  Infect Immun       Date:  1989-09       Impact factor: 3.441
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