| Literature DB >> 7973637 |
A Umar1, J C Boyer, T A Kunkel.
Abstract
An activity in human cell extracts is described that repairs DNA with loops of five or more unpaired bases. Repair is strand-specific and is directed by a nick located 5' or 3' to the loop. This repair is observed in a colorectal cancer cell line that is devoid of a wild-type hMLH1 gene and is deficient in repair of mismatches. However, a cell line with deletions in both hMSH2 alleles is deficient in repair of both loops and mismatches. Defects in loop repair may be relevant to the repetitive-sequence instability observed in cancers and other hereditary diseases.Entities:
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Year: 1994 PMID： 7973637 DOI： 10.1126/science.7973637
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728