Literature DB >> 12399405

Incorporation of large heterologies into heteroduplex DNA during double-strand-break repair in mouse cells.

Steven J Raynard1, Mark D Baker.   

Abstract

In this study, the formation and repair of large (>1 kb) insertion/deletion (I/D) heterologies during double-strand-break repair (DSBR) was investigated using a gene-targeting assay that permits efficient recovery of sequence insertion events at the haploid chromosomal immunoglobulin (Ig) mu-locus in mouse hybridoma cells. The results revealed that (i) large I/D heterologies were generated on one or both sides of the DSB and, in some cases, formed symmetrically in both homology regions; (ii) large I/D heterologies did not negatively affect the gene targeting frequency; and (iii) prior to DNA replication, the large I/D heterologies were rectified.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 12399405      PMCID： PMC1462280     

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  61 in total

1.  Repair of large insertion/deletion heterologies in human nuclear extracts is directed by a 5' single-strand break and is independent of the mismatch repair system.

Authors:  S J Littman; W H Fang; P Modrich
Journal:  J Biol Chem       Date:  1999-03-12       Impact factor: 5.157

2.  The role of the mismatch repair machinery in regulating mitotic and meiotic recombination between diverged sequences in yeast.

Authors:  W Chen; S Jinks-Robertson
Journal:  Genetics       Date:  1999-04       Impact factor: 4.562

Review 3.  Roles of the DNA mismatch repair and nucleotide excision repair proteins during meiosis.

Authors:  D T Kirkpatrick
Journal:  Cell Mol Life Sci       Date:  1999-03       Impact factor: 9.261

4.  Mechanisms of double-strand-break repair during gene targeting in mammalian cells.

Authors:  P Ng; M D Baker
Journal:  Genetics       Date:  1999-03       Impact factor: 4.562

5.  Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells.

Authors:  M Takata; M S Sasaki; E Sonoda; C Morrison; M Hashimoto; H Utsumi; Y Yamaguchi-Iwai; A Shinohara; S Takeda
Journal:  EMBO J       Date:  1998-09-15       Impact factor: 11.598

6.  Dual roles for DNA sequence identity and the mismatch repair system in the regulation of mitotic crossing-over in yeast.

Authors:  A Datta; M Hendrix; M Lipsitch; S Jinks-Robertson
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-02       Impact factor: 11.205

7.  Homology-directed repair is a major double-strand break repair pathway in mammalian cells.

Authors:  F Liang; M Han; P J Romanienko; M Jasin
Journal:  Proc Natl Acad Sci U S A       Date:  1998-04-28       Impact factor: 11.205

8.  Correction of large mispaired DNA loops by extracts of Saccharomyces cerevisiae.

Authors:  S E Corrette-Bennett; B O Parker; N L Mohlman; R S Lahue
Journal:  J Biol Chem       Date:  1999-06-18       Impact factor: 5.157

9.  Microsatellite instability in yeast: dependence on repeat unit size and DNA mismatch repair genes.

Authors:  E A Sia; R J Kokoska; M Dominska; P Greenwell; T D Petes
Journal:  Mol Cell Biol       Date:  1997-05       Impact factor: 4.272

10.  Analysis of in vivo correction of defined mismatches in the DNA mismatch repair mutants msh2, msh3 and msh6 of Saccharomyces cerevisiae.

Authors:  B Lühr; J Scheller; P Meyer; W Kramer
Journal:  Mol Gen Genet       Date:  1998-02
View more
  3 in total

1.  Opposing roles for DNA structure-specific proteins Rad1, Msh2, Msh3, and Sgs1 in yeast gene targeting.

Authors:  Lance D Langston; Lorraine S Symington
Journal:  EMBO J       Date:  2005-05-26       Impact factor: 11.598

2.  DNA polymerase delta, RFC and PCNA are required for repair synthesis of large looped heteroduplexes in Saccharomyces cerevisiae.

Authors:  Stephanie E Corrette-Bennett; Claudia Borgeson; Debbie Sommer; Peter M J Burgers; Robert S Lahue
Journal:  Nucleic Acids Res       Date:  2004-12-01       Impact factor: 16.971

3.  Partial reconstitution of DNA large loop repair with purified proteins from Saccharomyces cerevisiae.

Authors:  Debbie Sommer; Carrie M Stith; Peter M J Burgers; Robert S Lahue
Journal:  Nucleic Acids Res       Date:  2008-07-15       Impact factor: 16.971
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.