Literature DB >> 7972105

Overexpression of human cyclin D1 reduces the transforming growth factor beta (TGF-beta) type II receptor and growth inhibition by TGF-beta 1 in an immortalized human esophageal epithelial cell line.

A Okamoto1, W Jiang, S J Kim, E A Spillare, G D Stoner, I B Weinstein, C C Harris.   

Abstract

Cyclin D1 has been implicated in G1 cell cycle progression and is frequently amplified, overtranscribed, and oversynthesized in human tumors, including esophageal carcinomas. To further address the role of cyclin D1 in cell cycle control and tumorigenesis, we have stably transfected the human cyclin D1 in the nontumorigenic esophageal epithelial cell line HET-1A. These transfected cells, which express increased amounts of cyclin D1, have enhanced colony-forming efficiency and saturation density and are resistant to growth inhibition by TGF-beta 1 compared with the parental cell line or a control vector cell clone. The clones which express increased amounts of cyclin D1 exhibited a decrease in the amount of TGF-beta type II receptor, indicating a plausible mechanism for their diminished response to TGF-beta 1. Therefore, deregulated expression of the cyclin D1 gene can modulate the negative growth factor pathway of TGF-beta 1 and may disturb the control of epithelial cell proliferation in esophageal carcinogenesis.

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Year:  1994        PMID： 7972105      PMCID： PMC45274          DOI： 10.1073/pnas.91.24.11576

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  39 in total

Review 1.  Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta).

Authors:  A B Roberts; M B Sporn
Journal:  Growth Factors       Date:  1993       Impact factor: 2.511

2.  Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

Authors:  V Baldin; J Lukas; M J Marcote; M Pagano; G Draetta
Journal:  Genes Dev       Date:  1993-05       Impact factor: 11.361

3.  Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation.

Authors:  Y Xiong; H Zhang; D Beach
Journal:  Genes Dev       Date:  1993-08       Impact factor: 11.361

4.  TGF beta inhibition of Cdk4 synthesis is linked to cell cycle arrest.

Authors:  M E Ewen; H K Sluss; L L Whitehouse; D M Livingston
Journal:  Cell       Date:  1993-09-24       Impact factor: 41.582

5.  TGF beta signals through a heteromeric protein kinase receptor complex.

Authors:  J L Wrana; L Attisano; J Cárcamo; A Zentella; J Doody; M Laiho; X F Wang; J Massagué
Journal:  Cell       Date:  1992-12-11       Impact factor: 41.582

6.  Transforming growth factor beta effects on expression of G1 cyclins and cyclin-dependent protein kinases.

Authors:  Y Geng; R A Weinberg
Journal:  Proc Natl Acad Sci U S A       Date:  1993-11-01       Impact factor: 11.205

7.  Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.

Authors:  D E Quelle; R A Ashmun; S A Shurtleff; J Y Kato; D Bar-Sagi; M F Roussel; C J Sherr
Journal:  Genes Dev       Date:  1993-08       Impact factor: 11.361

8.  Growth inhibition by transforming growth factor beta (TGF-beta) type I is restored in TGF-beta-resistant hepatoma cells after expression of TGF-beta receptor type II cDNA.

Authors:  M Inagaki; A Moustakas; H Y Lin; H F Lodish; B I Carr
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-01       Impact factor: 11.205

9.  Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer.

Authors:  W Jiang; Y J Zhang; S M Kahn; M C Hollstein; R M Santella; S H Lu; C C Harris; R Montesano; I B Weinstein
Journal:  Proc Natl Acad Sci U S A       Date:  1993-10-01       Impact factor: 11.205

10.  Amplification and overexpression of cyclin D1 in human hepatocellular carcinoma.

Authors:  Y J Zhang; W Jiang; C J Chen; C S Lee; S M Kahn; R M Santella; I B Weinstein
Journal:  Biochem Biophys Res Commun       Date:  1993-10-29       Impact factor: 3.575
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  12 in total

1.  Responsiveness to transforming growth factor-beta (TGF-beta)-mediated growth inhibition is a function of membrane-bound TGF-beta type II receptor in human breast cancer cells.

Authors:  M A Lynch; T A Petrel; H Song; T J Knobloch; B C Casto; D Ramljak; L M Anderson; V DeGroff; G D Stoner; R W Brueggemeier; C M Weghorst
Journal:  Gene Expr       Date:  2001

2.  Acceleration of c-myc-induced hepatocarcinogenesis by Co-expression of transforming growth factor (TGF)-alpha in transgenic mice is associated with TGF-beta1 signaling disruption.

Authors:  E Santoni-Rugiu; M R Jensen; V M Factor; S S Thorgeirsson
Journal:  Am J Pathol       Date:  1999-06       Impact factor: 4.307

Review 3.  Defects of TGF-beta receptor signaling in mammary cell tumorigenesis.

Authors:  M G Brattain; Y Ko; S S Banerji; G Wu; J K Willson
Journal:  J Mammary Gland Biol Neoplasia       Date:  1996-10       Impact factor: 2.673

4.  Expression of cyclin D1 in epithelial tissues of transgenic mice results in epidermal hyperproliferation and severe thymic hyperplasia.

Authors:  A I Robles; F Larcher; R B Whalin; R Murillas; E Richie; I B Gimenez-Conti; J L Jorcano; C J Conti
Journal:  Proc Natl Acad Sci U S A       Date:  1996-07-23       Impact factor: 11.205

Review 5.  The role of transforming growth factor beta in glioma progression.

Authors:  M T Jennings; J A Pietenpol
Journal:  J Neurooncol       Date:  1998-01       Impact factor: 4.130

6.  Effect of growth factors and prostaglandin E2 on restitution and proliferation of rabbit esophageal epithelial cells.

Authors:  P Jimenez; A Lanas; E Piazuelo; F Esteva
Journal:  Dig Dis Sci       Date:  1998-10       Impact factor: 3.199

7.  Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E.

Authors:  D Rousseau; R Kaspar; I Rosenwald; L Gehrke; N Sonenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1996-02-06       Impact factor: 11.205

8.  TGF-B and Estrogen Regulate P27(Kip1) and Cyclin D(1) in Normal and Neoplastic Rat Pituitary Cells.

Authors:  Xiang Qian; Long Jin; Ricardo V. Lloyd
Journal:  Endocr Pathol       Date:  1997       Impact factor: 3.943

9.  Effects of phenylethyl isothiocyanate on early molecular events in N-nitrosomethylbenzylamine-induced cytotoxicity in rat esophagus.

Authors:  Rashmeet K Reen; Alan A Dombkowski; Laura A Kresty; Daniela Cukovic; Jennifer M Mele; Sridevi Salagrama; Ronald Nines; Gary D Stoner
Journal:  Cancer Res       Date:  2007-07-01       Impact factor: 12.701

10.  KSHV LANA inhibits TGF-beta signaling through epigenetic silencing of the TGF-beta type II receptor.

Authors:  Daniel L Di Bartolo; Mark Cannon; Yi-Fang Liu; Rolf Renne; Amy Chadburn; Chris Boshoff; Ethel Cesarman
Journal:  Blood       Date:  2008-01-16       Impact factor: 22.113
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