Literature DB >> 8389483

Growth inhibition by transforming growth factor beta (TGF-beta) type I is restored in TGF-beta-resistant hepatoma cells after expression of TGF-beta receptor type II cDNA.

M Inagaki1, A Moustakas, H Y Lin, H F Lodish, B I Carr.   

Abstract

The growth of human hepatoma Hep 3B cells is potently inhibited by TGF-beta 1 (ID50 = 0.2 ng/ml, 8 pM). A mutant cell line was derived that was not inhibited in growth by TGF-beta 1 at 5 ng/ml (200 pM) and that lacked TGF-beta receptor type II (TGF-beta RII) gene. Transfection of the cloned cDNA for human TGF-beta RII to this mutant cell line restored receptor expression as well as the inhibition in growth by TGF-beta 1. In both wild-type and mutant cells stably transfected with TGF-beta RII cDNA, TGF-beta RII coimmunoprecipitated with TGF-beta receptor type I in the presence of ligand. These experiments provide direct evidence for the role of TGF-beta RII in the inhibitory effect of TGF-beta on growth and suggest that TGF-beta RII acts by means of a heteromeric surface complex with TGF-beta receptor type I.

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Year:  1993        PMID： 8389483      PMCID： PMC46716          DOI： 10.1073/pnas.90.11.5359

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  27 in total

1.  Receptors for the TGF-beta superfamily: multiple polypeptides and serine/threonine kinases.

Authors:  H Y Lin; H F Lodish
Journal:  Trends Cell Biol       Date:  1993-01       Impact factor: 20.808

2.  Responsiveness to transforming growth factor-beta (TGF-beta) restored by genetic complementation between cells defective in TGF-beta receptors I and II.

Authors:  M Laiho; F M Weis; F T Boyd; R A Ignotz; J Massagué
Journal:  J Biol Chem       Date:  1991-05-15       Impact factor: 5.157

3.  TGF-beta in liver development, regeneration, and carcinogenesis.

Authors:  N Fausto; J E Mead; P A Gruppuso; L Braun
Journal:  Ann N Y Acad Sci       Date:  1990       Impact factor: 5.691

4.  Transforming growth factor-beta inhibition of epithelial cell proliferation linked to the expression of a 53-kDa membrane receptor.

Authors:  F T Boyd; J Massagué
Journal:  J Biol Chem       Date:  1989-02-05       Impact factor: 5.157

5.  A human beta-actin expression vector system directs high-level accumulation of antisense transcripts.

Authors:  P Gunning; J Leavitt; G Muscat; S Y Ng; L Kedes
Journal:  Proc Natl Acad Sci U S A       Date:  1987-07       Impact factor: 11.205

6.  Binding of transforming growth factor-beta to cell surface proteins varies with cell type.

Authors:  P R Segarini; D M Rosen; S M Seyedin
Journal:  Mol Endocrinol       Date:  1989-02

7.  The transforming growth factor-beta system, a complex pattern of cross-reactive ligands and receptors.

Authors:  S Cheifetz; J A Weatherbee; M L Tsang; J K Anderson; J E Mole; R Lucas; J Massagué
Journal:  Cell       Date:  1987-02-13       Impact factor: 41.582

8.  Structure and properties of the cellular receptor for transforming growth factor type beta.

Authors:  B O Fanger; L M Wakefield; M B Sporn
Journal:  Biochemistry       Date:  1986-06-03       Impact factor: 3.162

9.  Transforming growth factor-beta (TGF-beta)-resistant helper T lymphocyte clones show a concomitant loss of all three types of TGF-beta receptors.

Authors:  C Siepl; U V Malipiero; A Fontana
Journal:  J Immunol       Date:  1991-05-01       Impact factor: 5.422

10.  Absence of TGF-beta receptors and growth inhibitory responses in retinoblastoma cells.

Authors:  A Kimchi; X F Wang; R A Weinberg; S Cheifetz; J Massagué
Journal:  Science       Date:  1988-04-08       Impact factor: 47.728
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  46 in total

1.  Responsiveness to transforming growth factor-beta (TGF-beta)-mediated growth inhibition is a function of membrane-bound TGF-beta type II receptor in human breast cancer cells.

Authors:  M A Lynch; T A Petrel; H Song; T J Knobloch; B C Casto; D Ramljak; L M Anderson; V DeGroff; G D Stoner; R W Brueggemeier; C M Weghorst
Journal:  Gene Expr       Date:  2001

2.  Role of Radiation-induced TGF-beta Signaling in Cancer Therapy.

Authors:  Horatiu C Dancea; Mohammed M Shareef; Mansoor M Ahmed
Journal:  Mol Cell Pharmacol       Date:  2009

3.  Effects of Chinese traditional compound, JinSanE, on expression of TGF-beta1 and TGF-beta1 type II receptor mRNA, Smad3 and Smad7 on experimental hepatic fibrosis in vivo.

Authors:  Shi-Ling Song; Zuo-Jiong Gong; Quan-Rong Zhang; Tuan-Xin Huang
Journal:  World J Gastroenterol       Date:  2005-04-21       Impact factor: 5.742

4.  Ultraviolet irradiation represses TGF-β type II receptor transcription through a 38-bp sequence in the proximal promoter in human skin fibroblasts.

Authors:  Tianyuan He; Taihao Quan; Gary J Fisher
Journal:  Exp Dermatol       Date:  2014-10       Impact factor: 3.960

5.  Characterization of a human hepatoma cell line with acquired resistance to growth inhibition by transforming growth factor beta 1 (TGF-beta 1).

Authors:  K Hasegawa; Z Wang; M Inagaki; B I Carr
Journal:  In Vitro Cell Dev Biol Anim       Date:  1995-01       Impact factor: 2.416

6.  Different domains regulate homomeric and heteromeric complex formation among type I and type II transforming growth factor-beta receptors.

Authors:  Maya Mouler Rechtman; Alex Nakaryakov; Keren E Shapira; Marcelo Ehrlich; Yoav I Henis
Journal:  J Biol Chem       Date:  2009-01-15       Impact factor: 5.157

7.  Transforming growth factor-beta type-II receptor signalling: intrinsic/associated casein kinase activity, receptor interactions and functional effects of blocking antibodies.

Authors:  F L Hall; P D Benya; S R Padilla; D Carbonaro-Hall; R Williams; S Buckley; D Warburton
Journal:  Biochem J       Date:  1996-05-15       Impact factor: 3.857

8.  The transforming growth factor beta type II receptor can replace the activin type II receptor in inducing mesoderm.

Authors:  A Bhushan; H Y Lin; H F Lodish; C R Kintner
Journal:  Mol Cell Biol       Date:  1994-06       Impact factor: 4.272

9.  Reconstitution of a pentameric complex of dimeric transforming growth factor beta ligand and a type I, II, III receptor in baculoviral-infected insect cells.

Authors:  K Matsuzaki; M Kan; W L McKeehan
Journal:  In Vitro Cell Dev Biol Anim       Date:  1996-06       Impact factor: 2.416

Review 10.  The multifunctional role of transforming growth factor (TGF)-beta s on mammary epithelial cell biology.

Authors:  C L Arteaga; T C Dugger; S D Hurd
Journal:  Breast Cancer Res Treat       Date:  1996       Impact factor: 4.872
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