Literature DB >> 7694291

Transforming growth factor beta effects on expression of G1 cyclins and cyclin-dependent protein kinases.

Y Geng1, R A Weinberg.   

Abstract

Transforming growth factor beta 1 (TGF-beta 1) is a potent growth-inhibitory polypeptide. The mechanism of TGF-beta 1 inhibition has been related to its ability to prevent the hyperphosphorylation of retinoblastoma protein (pRb). Several lines of evidence have suggested that cell cycle-regulated protein kinases are responsible for the hyperphosphorylation of pRb. We demonstrate here that TGF-beta 1 has profound effects on the expression of genes encoding certain G1 cyclins and their associated kinases, which provides one explanation of TGF-beta 1 effects on pRb hyperphosphorylation. These results also suggest that the growth-inhibitory effects of TGF-beta 1 in many cells are attributable to its effects on the cell cycle apparatus involved in programming G1 transit.

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Year:  1993        PMID： 7694291      PMCID： PMC47765          DOI： 10.1073/pnas.90.21.10315

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  34 in total

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Journal:  Cell       Date:  1991-05-17       Impact factor: 41.582

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Journal:  Mol Cell Biol       Date:  1991-03       Impact factor: 4.272

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Journal:  EMBO J       Date:  1991-04       Impact factor: 11.598
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  56 in total

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Journal:  J Biol Chem       Date:  2011-04-22       Impact factor: 5.157

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Authors:  P W Hinds; S F Dowdy; E N Eaton; A Arnold; R A Weinberg
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7.  TGF-beta signaling pathway inactivation and cell cycle deregulation in the development of gastric cancer: role of the beta-spectrin, ELF.

Authors:  Sang Soo Kim; Kirti Shetty; Varalakshmi Katuri; Krit Kitisin; Hye Jung Baek; Yi Tang; Blair Marshall; Lynt Johnson; Bibhuti Mishra; Lopa Mishra
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8.  Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling.

Authors:  Daizo Koinuma; Shuichi Tsutsumi; Naoko Kamimura; Hirokazu Taniguchi; Keiji Miyazawa; Makoto Sunamura; Takeshi Imamura; Kohei Miyazono; Hiroyuki Aburatani
Journal:  Mol Cell Biol       Date:  2008-10-27       Impact factor: 4.272

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Authors:  R U Jänicke; X Y Lin; F H Lee; A G Porter
Journal:  Mol Cell Biol       Date:  1996-10       Impact factor: 4.272

10.  A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells.

Authors:  J M Slingerland; L Hengst; C H Pan; D Alexander; M R Stampfer; S I Reed
Journal:  Mol Cell Biol       Date:  1994-06       Impact factor: 4.272
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