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Literature DB >> 7969747

Age-dependent loss of NMDA receptors in hippocampus, striatum, and frontal cortex of the rat: prevention by acetyl-L-carnitine.

M Castorina¹, A M Ambrosini, L Pacific, M T Ramacci, L Angelucci.

Abstract

Acute i.p. administration of Acetyl-L-Carnitine (ALCAR), a component of several biological systems, has been found to modify spontaneous and evoked electrocortical activity in young rats, and, in the old rats, to improve learning ability and to increase the number of NMDA receptors in the whole brain. The present study was aimed at ascertaining the effect of chronic treatment with ALCAR added to drinking water on age-related changes in the different brain areas of rats. In twenty-four-month-old rats, ALCAR treatment for six months significantly impeded the decline in the number of NMDA receptors within the hippocampus, the frontal cortex and the striatum compared to the adult animal. This finding thus confirms the previously reported positive effect of ALCAR on the brain NMDA receptor system.

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Year: 1994 PMID： 7969747 DOI： 10.1007/BF00967446

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

37 in total

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Authors: W Danysz; J T Wroblewski; E Costa
Journal: Neuropharmacology Date: 1988-06 Impact factor: 5.250

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Authors: W J Schmidt; M Bubser
Journal: Pharmacol Biochem Behav Date: 1989-03 Impact factor: 3.533

6. Age-dependent nerve cell loss in the brain of Sprague-Dawley rats: effect of long term acetyl-L-carnitine treatment.

Authors: P Napoleone; F Ferrante; O Ghirardi; M T Ramacci; F Amenta
Journal: Arch Gerontol Geriatr Date: 1990 Mar-Apr Impact factor: 3.250

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Authors: W Bondareff
Journal: Mech Ageing Dev Date: 1979-01 Impact factor: 5.432

8. Characterization of the binding of [3H]-CGS 19755: a novel N-methyl-D-aspartate antagonist with nanomolar affinity in rat brain.

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9. Neuroleptic-induced catalepsy as a model of Parkinson's disease. II. Effect of glutamate antagonists.

Authors: P J Elliott; S P Close; D M Walsh; A G Hayes; A S Marriott
Journal: J Neural Transm Park Dis Dement Sect Date: 1990

10. Effect of acetyl-L-carnitine on the dopaminergic system in aging brain.

Authors: H Sershen; L G Harsing; M Banay-Schwartz; A Hashim; M T Ramacci; A Lajtha
Journal: J Neurosci Res Date: 1991-11 Impact factor: 4.164

8 in total

1. Long-term replacement of estrogen in combination with medroxyprogesterone acetate improves acquisition of an alternation task in middle-aged female rats.

Authors: Nioka C Chisholm; Janice M Juraska
Journal: Behav Neurosci Date: 2011-12-05 Impact factor: 1.912

2. The function of the glutamate-nitric oxide-cGMP pathway in brain in vivo and learning ability decrease in parallel in mature compared with young rats.

Authors: Blanca Piedrafita; Omar Cauli; Carmina Montoliu; Vicente Felipo
Journal: Learn Mem Date: 2007-04-05 Impact factor: 2.460

Age-dependent loss of NMDA receptors in hippocampus, striatum, and frontal cortex of the rat: prevention by acetyl-L-carnitine.

1. Learning impairment in rats by N-methyl-D-aspartate receptor antagonists.

2. Impaired synaptic potentiation processes in the hippocampus of aged, memory-deficient rats.

3. A glutamatergic corticostriatal path?

4. Nerve growth factor binding in aged rat central nervous system: effect of acetyl-L-carnitine.

5. Anticataleptic effects of the N-methyl-D-aspartate antagonist MK-801 in rats.

6. Age-dependent nerve cell loss in the brain of Sprague-Dawley rats: effect of long term acetyl-L-carnitine treatment.

7. Synaptic atrophy in the senescent hippocampus.

8. Characterization of the binding of [3H]-CGS 19755: a novel N-methyl-D-aspartate antagonist with nanomolar affinity in rat brain.

9. Neuroleptic-induced catalepsy as a model of Parkinson's disease. II. Effect of glutamate antagonists.

10. Effect of acetyl-L-carnitine on the dopaminergic system in aging brain.

1. Long-term replacement of estrogen in combination with medroxyprogesterone acetate improves acquisition of an alternation task in middle-aged female rats.

2. The function of the glutamate-nitric oxide-cGMP pathway in brain in vivo and learning ability decrease in parallel in mature compared with young rats.

3. The effects of aging and genotype on NMDA receptor expression in growth hormone receptor knockout (GHRKO) mice.

4. Action of L-acetylcarnitine on different cerebral mitochondrial populations from cerebral cortex.

5. Selective Vulnerabilities of N-methyl-D-aspartate (NMDA) Receptors During Brain Aging.

6. Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity.

7. Docosahexaenoic Acid Helps to Lessen Extinction Memory in Rats.

Review 8. Acetyl-L-Carnitine in Dementia and Other Cognitive Disorders: A Critical Update.