Literature DB >> 2914602

A unique signature identifies a family of zinc-dependent metallopeptidases.

C V Jongeneel1, J Bouvier, A Bairoch.   

Abstract

The primary sequence motif HExxH has been found in many zinc-dependent endopeptidases. We show that a larger signature comprising this sequence is common to most of the known zinc-dependent endopeptidases, and that the presence of the signature can be indicative of membership in the family. A search of the protein sequence databases for entries containing the signature retrieved several unexpected potential zinc endopeptidases.

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Year:  1989        PMID： 2914602     DOI： 10.1016/0014-5793(89)80471-5

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


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