Literature DB >> 7961481

The leader peptides of attenuation-regulated chloramphenicol resistance genes inhibit translational termination.

J G Moffat1, W P Tate, P S Lovett.   

Abstract

Placing a translation stop codon at the ribosomal pause site in the leader of the attenuation-regulated cat-86 gene activates cat expression in the absence of the inducer, chloramphenicol. Genetic experiments have shown that this phenomenon depends on the amino acid sequence of the leader-encoded peptide and could readily be explained if the peptide was an inhibitor of translation termination. Here we demonstrate that the cat-86 leader pentapeptide is an in vitro inhibitor of translation termination in addition to its previously described antipeptidyltransferase activity.

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Year:  1994        PMID： 7961481      PMCID： PMC197091          DOI： 10.1128/jb.176.22.7115-7117.1994

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  14 in total

Review 1.  Translational termination: "stop" for protein synthesis or "pause" for regulation of gene expression.

Authors:  W P Tate; C M Brown
Journal:  Biochemistry       Date:  1992-03-10       Impact factor: 3.162

2.  Peptidyl transferase inhibition by the nascent leader peptide of an inducible cat gene.

Authors:  Z Gu; E J Rogers; P S Lovett
Journal:  J Bacteriol       Date:  1993-09       Impact factor: 3.490

3.  ermC leader peptide. Amino acid sequence critical for induction by translational attenuation.

Authors:  M Mayford; B Weisblum
Journal:  J Mol Biol       Date:  1989-03-05       Impact factor: 5.469

4.  Properties of a pentapeptide inhibitor of peptidyltransferase that is essential for cat gene regulation by translation attenuation.

Authors:  Z Gu; R Harrod; E J Rogers; P S Lovett
Journal:  J Bacteriol       Date:  1994-10       Impact factor: 3.490

5.  The cis-effect of a nascent peptide on its translating ribosome: influence of the cat-86 leader pentapeptide on translation termination at leader codon 6.

Authors:  E J Rogers; P S Lovett
Journal:  Mol Microbiol       Date:  1994-04       Impact factor: 3.501

6.  Ribosome-catalysed reaction of puromycin with a formylmethionine-containing oligonucleotide.

Authors:  R E Monro; K A Marcker
Journal:  J Mol Biol       Date:  1967-04-28       Impact factor: 5.469

7.  Ribosome-catalysed peptidyl transfer: effects of some inhibitors of protein synthesis.

Authors:  R E Monro; D Vazquez
Journal:  J Mol Biol       Date:  1967-08-28       Impact factor: 5.469

8.  Bacillus subtilis mutant allele sup-3 causes lysine insertion at ochre codons: use of sup-3 in studies of translational attenuation.

Authors:  W W Mulbry; N P Ambulos; P S Lovett
Journal:  J Bacteriol       Date:  1989-10       Impact factor: 3.490

9.  Anti-peptidyl transferase leader peptides of attenuation-regulated chloramphenicol-resistance genes.

Authors:  Z Gu; R Harrod; E J Rogers; P S Lovett
Journal:  Proc Natl Acad Sci U S A       Date:  1994-06-07       Impact factor: 11.205

10.  Chloramphenicol induction of cat-86 requires ribosome stalling at a specific site in the leader.

Authors:  Z Alexieva; E J Duvall; N P Ambulos; U J Kim; P S Lovett
Journal:  Proc Natl Acad Sci U S A       Date:  1988-05       Impact factor: 11.205
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  10 in total

1.  Leader peptides of inducible chloramphenicol resistance genes from gram-positive and gram-negative bacteria bind to yeast and Archaea large subunit rRNA.

Authors:  R Harrod; P S Lovett
Journal:  Nucleic Acids Res       Date:  1997-05-01       Impact factor: 16.971

2.  A UV-induced mutation in neurospora that affects translational regulation in response to arginine.

Authors:  M Freitag; N Dighde; M S Sachs
Journal:  Genetics       Date:  1996-01       Impact factor: 4.562

3.  Inhibition of the release factor-dependent termination reaction on ribosomes by DnaJ and the N-terminal peptide of rhodanese.

Authors:  W Kudlicki; O W Odom; G Merrill; G Kramer; B Hardesty
Journal:  J Bacteriol       Date:  1995-10       Impact factor: 3.490

4.  Peptide inhibitors of peptidyltransferase alter the conformation of domains IV and V of large subunit rRNA: a model for nascent peptide control of translation.

Authors:  R Harrod; P S Lovett
Journal:  Proc Natl Acad Sci U S A       Date:  1995-09-12       Impact factor: 11.205

5.  Selection of aminoacyl-tRNAs at sense codons: the size of the tRNA variable loop determines whether the immediate 3' nucleotide to the codon has a context effect.

Authors:  J F Curran; E S Poole; W P Tate; B L Gross
Journal:  Nucleic Acids Res       Date:  1995-10-25       Impact factor: 16.971

6.  Aminoglycoside antibiotics mediate context-dependent suppression of termination codons in a mammalian translation system.

Authors:  M Manuvakhova; K Keeling; D M Bedwell
Journal:  RNA       Date:  2000-07       Impact factor: 4.942

7.  Evidence suggesting cis action by the TnaC leader peptide in regulating transcription attenuation in the tryptophanase operon of Escherichia coli.

Authors:  K Gish; C Yanofsky
Journal:  J Bacteriol       Date:  1995-12       Impact factor: 3.490

8.  Synthetic RNA silencing in bacteria - antimicrobial discovery and resistance breaking.

Authors:  Liam Good; James E M Stach
Journal:  Front Microbiol       Date:  2011-09-12       Impact factor: 5.640

9.  Translation of the first upstream ORF in the hepatitis B virus pregenomic RNA modulates translation at the core and polymerase initiation codons.

Authors:  Augustine Chen; Y F Kao; Chris M Brown
Journal:  Nucleic Acids Res       Date:  2005-02-24       Impact factor: 16.971

Review 10.  Translation in plants--rules and exceptions.

Authors:  J Fütterer; T Hohn
Journal:  Plant Mol Biol       Date:  1996-10       Impact factor: 4.076
  10 in total

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