Literature DB >> 7961114

Role of orthotopic fibroblasts in the development of scirrhous gastric carcinoma.

M Yashiro1, Y S Chung, M Sowa.   

Abstract

We examined the interaction between scirrhous gastric cancer cells and organ-specific fibroblasts in vivo and in vitro. Co-inoculation of scirrhous gastric cancer cells with gastric fibroblasts into nude mice specifically increased tumorigenicity, compared with that of gastric cancer cells alone. Furthermore, the histologic findings of the xenograft produced by co-inoculation with gastric fibroblasts was similar to that of human scirrhous gastric carcinoma. Conditioned medium from gastric fibroblasts significantly stimulated the growth of gastric cancer cells. These findings suggest that the growth of scirrhous gastric cancer cells was affected by orthotopic fibroblasts.

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Year:  1994        PMID: 7961114      PMCID: PMC5919589          DOI: 10.1111/j.1349-7006.1994.tb02963.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN: 0910-5050


  10 in total

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  10 in total
  20 in total

1.  An Insufficient Preoperative Diagnosis of Borrmann Type 4 Gastric Cancer in Spite of EMR.

Authors:  Jae Bong Ahn; Tae Kyung Ha; Hang Rak Lee; Sung Joon Kwon
Journal:  J Gastric Cancer       Date:  2011-03-31       Impact factor: 3.720

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Authors:  Masakazu Yashiro; Kosei Hirakawa
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4.  Myofibroblasts are associated with the progression of scirrhous gastric carcinoma.

Authors:  Yuhiko Fuyuhiro; Masakazu Yashiro; Satoru Noda; Shinichiro Kashiwagi; Junko Matsuoka; Yosuke Doi; Yukihiro Kato; Kazuya Muguruma; Tetsuji Sawada; Kosei Hirakawa
Journal:  Exp Ther Med       Date:  2010-07-01       Impact factor: 2.447

Review 5.  The significance of scirrhous gastric cancer cell lines: the molecular characterization using cell lines and mouse models.

Authors:  Masakazu Yashiro; Tasuku Matsuoka; Masaichi Ohira
Journal:  Hum Cell       Date:  2018-06-06       Impact factor: 4.174

Review 6.  Rho/ROCK signaling in motility and metastasis of gastric cancer.

Authors:  Tasuku Matsuoka; Masakazu Yashiro
Journal:  World J Gastroenterol       Date:  2014-10-14       Impact factor: 5.742

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Authors:  T Matsuoka; K Hirakawa; Y S Chung; M Yashiro; S Nishimura; T Sawada; I Saiki; M Sowa
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Journal:  Cancer Metastasis Rev       Date:  1995-12       Impact factor: 9.264

9.  Peritoneal metastatic model for human scirrhous gastric carcinoma in nude mice.

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Journal:  Clin Exp Metastasis       Date:  1996-01       Impact factor: 5.150

Review 10.  Molecular targets for the treatment of pancreatic cancer: Clinical and experimental studies.

Authors:  Tasuku Matsuoka; Masakazu Yashiro
Journal:  World J Gastroenterol       Date:  2016-01-14       Impact factor: 5.742

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