Literature DB >> 21209779

Cancer-stromal interactions in scirrhous gastric carcinoma.

Masakazu Yashiro, Kosei Hirakawa.   

Abstract

Fibroblasts play an important role in the progression, growth and spread of gastric cancers. Cancer-stroma interactions have been especially evident in the scirrhous type of gastric carcinoma. Fibroblasts are associated with the cancer progression at the primary and metastatic site. The proliferative and invasive ability of scirrhous gastric cancer cells are closely associated with the growth factors produced by organ-specific fibroblasts. Fibroblasts are therefore a key determinant in the malignant progression of gastric cancer and represent an important target for cancer therapies.

Entities:  

Keywords:  Fibroblasts; Growth factor; Interaction; Microenvironment; Scirrhous gastric cancer; Stromal cells

Year:  2010        PMID： 21209779      PMCID： PMC2990484          DOI： 10.1007/s12307-010-0036-5

Source DB:  PubMed          Journal:  Cancer Microenviron        ISSN： 1875-2284


  82 in total

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  43 in total

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2.  A digest on the role of the tumor microenvironment in gastrointestinal cancers.

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